Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS

Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS

Abstract Background Gene fusions are important cancer drivers in pediatric cancer and their accurate detection is essential for diagnosis and treatment. Clinical decision-making requires high confidence and precision of detection. Recent developments show RNA sequencing (RNA-seq) is promising for ge...

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Bibliographic Details
Main Authors: Ianthe A. E. M. van Belzen, Casey Cai, Marc van Tuil, Shashi Badloe, Eric Strengman, Alex Janse, Eugène T. P. Verwiel, Douwe F. M. van der Leest, Lennart Kester, Jan J. Molenaar, Jules Meijerink, Jarno Drost, Weng Chuan Peng, Hindrik H. D. Kerstens, Bastiaan B. J. Tops, Frank C. P. Holstege, Patrick Kemmeren, Jayne Y. Hehir-Kwa
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Cancer
Subjects:
Gene fusions
Chimeric transcripts
Pediatric cancer
Structural variants
Whole genome sequencing
RNA sequencing
Online Access:https://doi.org/10.1186/s12885-023-11054-3

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