Simulated Breathing: Application of Molecular Dynamics Simulations to Pulmonary Lung Surfactant
In this review, we delve into the topic of the pulmonary surfactant (PS) system, which is present in the respiratory system. The total composition of the PS has been presented and explored, from the types of cells involved in its synthesis and secretion, down to the specific building blocks used, su...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Symmetry |
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| Online Access: | https://www.mdpi.com/2073-8994/13/7/1259 |
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| author | Maksymilian Dziura Basel Mansour Mitchell DiPasquale P. Charukeshi Chandrasekera James W. Gauld Drew Marquardt |
| author_facet | Maksymilian Dziura Basel Mansour Mitchell DiPasquale P. Charukeshi Chandrasekera James W. Gauld Drew Marquardt |
| author_sort | Maksymilian Dziura |
| collection | DOAJ |
| description | In this review, we delve into the topic of the pulmonary surfactant (PS) system, which is present in the respiratory system. The total composition of the PS has been presented and explored, from the types of cells involved in its synthesis and secretion, down to the specific building blocks used, such as the various lipid and protein components. The lipid and protein composition varies across species and between individuals, but ultimately produces a PS monolayer with the same role. As such, the composition has been investigated for the ways in which it imposes function and confers peculiar biophysical characteristics to the system as a whole. Moreover, a couple of theories/models that are associated with the functions of PS have been addressed. Finally, molecular dynamic (MD) simulations of pulmonary surfactant have been emphasized to not only showcase various group’s findings, but also to demonstrate the validity and importance that MD simulations can have in future research exploring the PS monolayer system. |
| first_indexed | 2024-03-10T09:21:22Z |
| format | Article |
| id | doaj.art-046aca44788c4ee1b7b7bd2decc5c0c7 |
| institution | Directory Open Access Journal |
| issn | 2073-8994 |
| language | English |
| last_indexed | 2024-03-10T09:21:22Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Symmetry |
| spelling | doaj.art-046aca44788c4ee1b7b7bd2decc5c0c72023-11-22T05:09:38ZengMDPI AGSymmetry2073-89942021-07-01137125910.3390/sym13071259Simulated Breathing: Application of Molecular Dynamics Simulations to Pulmonary Lung SurfactantMaksymilian Dziura0Basel Mansour1Mitchell DiPasquale2P. Charukeshi Chandrasekera3James W. Gauld4Drew Marquardt5Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave, Windsor, ON N9B 3P4, CanadaIn this review, we delve into the topic of the pulmonary surfactant (PS) system, which is present in the respiratory system. The total composition of the PS has been presented and explored, from the types of cells involved in its synthesis and secretion, down to the specific building blocks used, such as the various lipid and protein components. The lipid and protein composition varies across species and between individuals, but ultimately produces a PS monolayer with the same role. As such, the composition has been investigated for the ways in which it imposes function and confers peculiar biophysical characteristics to the system as a whole. Moreover, a couple of theories/models that are associated with the functions of PS have been addressed. Finally, molecular dynamic (MD) simulations of pulmonary surfactant have been emphasized to not only showcase various group’s findings, but also to demonstrate the validity and importance that MD simulations can have in future research exploring the PS monolayer system.https://www.mdpi.com/2073-8994/13/7/1259pulmonary surfactantsurface tensionadsorptionphospholipidsproteinsmonolayer |
| spellingShingle | Maksymilian Dziura Basel Mansour Mitchell DiPasquale P. Charukeshi Chandrasekera James W. Gauld Drew Marquardt Simulated Breathing: Application of Molecular Dynamics Simulations to Pulmonary Lung Surfactant Symmetry pulmonary surfactant surface tension adsorption phospholipids proteins monolayer |
| title | Simulated Breathing: Application of Molecular Dynamics Simulations to Pulmonary Lung Surfactant |
| title_full | Simulated Breathing: Application of Molecular Dynamics Simulations to Pulmonary Lung Surfactant |
| title_fullStr | Simulated Breathing: Application of Molecular Dynamics Simulations to Pulmonary Lung Surfactant |
| title_full_unstemmed | Simulated Breathing: Application of Molecular Dynamics Simulations to Pulmonary Lung Surfactant |
| title_short | Simulated Breathing: Application of Molecular Dynamics Simulations to Pulmonary Lung Surfactant |
| title_sort | simulated breathing application of molecular dynamics simulations to pulmonary lung surfactant |
| topic | pulmonary surfactant surface tension adsorption phospholipids proteins monolayer |
| url | https://www.mdpi.com/2073-8994/13/7/1259 |
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