Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung

Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung

NiO nanoparticles were administered to rat lungs via intratracheal instillation or inhalation. During pulmonary toxicity caused by NiO nanoparticles, the induction of oxidative stress is a major factor. Both intratracheal instillation and inhalation of NiO nanoparticles induced pulmonary oxidative s...

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Bibliographic Details
Main Authors: Masanori Horie, Yukiko Yoshiura, Hiroto Izumi, Takako Oyabu, Taisuke Tomonaga, Takami Okada, Byeong-Woo Lee, Toshihiko Myojo, Masaru Kubo, Manabu Shimada, Yasuo Morimoto
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:Antioxidants
Subjects:
oxidative stress
nanoparticle
nickel oxide
inhalation
intratracheal instillation
Online Access:http://www.mdpi.com/2076-3921/5/1/4

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