Genome-Wide Association Study Reveals Candidate Genes for Growth Relevant Traits in Pigs

Improvement of the growth rate is a challenge in the pig industry, the Average Daily Gain (ADG) and Days (AGE) to 100 kg are directly related to growth performance. We performed genome-wide association study (GWAS) and genetic parameters estimation for ADG and AGE using the genomic and phonemic from...

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Main Authors: Zhenshuang Tang, Jingya Xu, Lilin Yin, Dong Yin, Mengjin Zhu, Mei Yu, Xinyun Li, Shuhong Zhao, Xiaolei Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00302/full
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author Zhenshuang Tang
Zhenshuang Tang
Jingya Xu
Jingya Xu
Lilin Yin
Lilin Yin
Dong Yin
Dong Yin
Mengjin Zhu
Mengjin Zhu
Mei Yu
Mei Yu
Xinyun Li
Xinyun Li
Shuhong Zhao
Shuhong Zhao
Xiaolei Liu
Xiaolei Liu
author_facet Zhenshuang Tang
Zhenshuang Tang
Jingya Xu
Jingya Xu
Lilin Yin
Lilin Yin
Dong Yin
Dong Yin
Mengjin Zhu
Mengjin Zhu
Mei Yu
Mei Yu
Xinyun Li
Xinyun Li
Shuhong Zhao
Shuhong Zhao
Xiaolei Liu
Xiaolei Liu
author_sort Zhenshuang Tang
collection DOAJ
description Improvement of the growth rate is a challenge in the pig industry, the Average Daily Gain (ADG) and Days (AGE) to 100 kg are directly related to growth performance. We performed genome-wide association study (GWAS) and genetic parameters estimation for ADG and AGE using the genomic and phonemic from four breed (Duroc, Yorkshire, Landrace, and Pietrain) populations. All analyses were performed by a multi-loci GWAS model, FarmCPU. The GWAS results of all four breeds indicate that five genome-wide significant SNPs were associated with ADG, and the nearby genomic regions explained 4.08% of the genetic variance and 1.90% of the phenotypic variance, respectively. For AGE, six genome-wide significant SNPs were detected, and the nearby genomic regions explained 8.09% of the genetic variance and 3.52% of phenotypic variance, respectively. In total, nine candidate genes were identified to be associated with growth and metabolism. Among them, TRIB3 was reported to associate with pig growth, GRP, TTR, CNR1, GLP1R, BRD2, HCRTR2, SEC11C, and ssc-mir-122 were reported to associate with growth traits in human and mouse. The newly detected candidate genes will advance the understanding of growth related traits and the identification of the novel variants will suggest a potential use in pig genomic breeding programs.
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spelling doaj.art-046f153240b748e2a3b3f01c73b3de982022-12-21T21:03:17ZengFrontiers Media S.A.Frontiers in Genetics1664-80212019-04-011010.3389/fgene.2019.00302445963Genome-Wide Association Study Reveals Candidate Genes for Growth Relevant Traits in PigsZhenshuang Tang0Zhenshuang Tang1Jingya Xu2Jingya Xu3Lilin Yin4Lilin Yin5Dong Yin6Dong Yin7Mengjin Zhu8Mengjin Zhu9Mei Yu10Mei Yu11Xinyun Li12Xinyun Li13Shuhong Zhao14Shuhong Zhao15Xiaolei Liu16Xiaolei Liu17Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education & College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education & College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education & College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education & College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education & College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education & College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education & College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education & College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education & College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, ChinaKey Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, ChinaImprovement of the growth rate is a challenge in the pig industry, the Average Daily Gain (ADG) and Days (AGE) to 100 kg are directly related to growth performance. We performed genome-wide association study (GWAS) and genetic parameters estimation for ADG and AGE using the genomic and phonemic from four breed (Duroc, Yorkshire, Landrace, and Pietrain) populations. All analyses were performed by a multi-loci GWAS model, FarmCPU. The GWAS results of all four breeds indicate that five genome-wide significant SNPs were associated with ADG, and the nearby genomic regions explained 4.08% of the genetic variance and 1.90% of the phenotypic variance, respectively. For AGE, six genome-wide significant SNPs were detected, and the nearby genomic regions explained 8.09% of the genetic variance and 3.52% of phenotypic variance, respectively. In total, nine candidate genes were identified to be associated with growth and metabolism. Among them, TRIB3 was reported to associate with pig growth, GRP, TTR, CNR1, GLP1R, BRD2, HCRTR2, SEC11C, and ssc-mir-122 were reported to associate with growth traits in human and mouse. The newly detected candidate genes will advance the understanding of growth related traits and the identification of the novel variants will suggest a potential use in pig genomic breeding programs.https://www.frontiersin.org/article/10.3389/fgene.2019.00302/fullGWASpiggrowth traitsADGAGE
spellingShingle Zhenshuang Tang
Zhenshuang Tang
Jingya Xu
Jingya Xu
Lilin Yin
Lilin Yin
Dong Yin
Dong Yin
Mengjin Zhu
Mengjin Zhu
Mei Yu
Mei Yu
Xinyun Li
Xinyun Li
Shuhong Zhao
Shuhong Zhao
Xiaolei Liu
Xiaolei Liu
Genome-Wide Association Study Reveals Candidate Genes for Growth Relevant Traits in Pigs
Frontiers in Genetics
GWAS
pig
growth traits
ADG
AGE
title Genome-Wide Association Study Reveals Candidate Genes for Growth Relevant Traits in Pigs
title_full Genome-Wide Association Study Reveals Candidate Genes for Growth Relevant Traits in Pigs
title_fullStr Genome-Wide Association Study Reveals Candidate Genes for Growth Relevant Traits in Pigs
title_full_unstemmed Genome-Wide Association Study Reveals Candidate Genes for Growth Relevant Traits in Pigs
title_short Genome-Wide Association Study Reveals Candidate Genes for Growth Relevant Traits in Pigs
title_sort genome wide association study reveals candidate genes for growth relevant traits in pigs
topic GWAS
pig
growth traits
ADG
AGE
url https://www.frontiersin.org/article/10.3389/fgene.2019.00302/full
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