EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES
Previous studies with some solid tumors has shown that polymorphisms of certain cytokine genes may be used as predictors of clinical outcome in the patients. It seemed important to evaluate potential correlations between production of certain pro- and anti-inflammatory cytokines and co-receptor mole...
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| Format: | Article |
| Jezik: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-11-01
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| Serija: | Медицинская иммунология |
| Teme: | |
| Online dostop: | https://www.mimmun.ru/mimmun/article/view/729 |
| _version_ | 1826534237613850624 |
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| author | E. L. Nazarova V. I. Shardakov V. T. Demyanova T. P. Zagoskina E. N. Zotina |
| author_facet | E. L. Nazarova V. I. Shardakov V. T. Demyanova T. P. Zagoskina E. N. Zotina |
| author_sort | E. L. Nazarova |
| collection | DOAJ |
| description | Previous studies with some solid tumors has shown that polymorphisms of certain cytokine genes may be used as predictors of clinical outcome in the patients. It seemed important to evaluate potential correlations between production of certain pro- and anti-inflammatory cytokines and co-receptor molecules, and promoter polymorphism of the cytokine genes involved into regulation of cell proliferation, differentiation, apoptosis, lipid metabolism and blood clotting in the patients with hematological malignancies. The article contains our results concerning associations between of IL-1β, -2, -4, -10, -17, TNFα, and allelic polymorphisms of their genes in 62 patients with B cell lymphoid malignancies in an ethnically homogenous group (self-identified as Russians. We have shown that the GА and AA genotypes of the G-308A polymorphism in TNFα gene are significantly associated with increased production of this cytokine, being more common in aggressive non-Hodgkin lymphomas, more rare in multiple myeloma and in indolent non-Hodgkin lymphomas. |
| first_indexed | 2024-03-08T05:50:18Z |
| format | Article |
| id | doaj.art-046f9e5ebcfe404ab59b6d05332763e0 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:19:50Z |
| publishDate | 2014-11-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-046f9e5ebcfe404ab59b6d05332763e02025-03-11T17:59:05ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-11-0116543143610.15789/1563-0625-2014-5-431-436709EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIESE. L. Nazarova0V. I. Shardakov1V. T. Demyanova2T. P. Zagoskina3E. N. Zotina4Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian FederationKirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian FederationKirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian FederationKirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian FederationKirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, Kirov, Russian FederationPrevious studies with some solid tumors has shown that polymorphisms of certain cytokine genes may be used as predictors of clinical outcome in the patients. It seemed important to evaluate potential correlations between production of certain pro- and anti-inflammatory cytokines and co-receptor molecules, and promoter polymorphism of the cytokine genes involved into regulation of cell proliferation, differentiation, apoptosis, lipid metabolism and blood clotting in the patients with hematological malignancies. The article contains our results concerning associations between of IL-1β, -2, -4, -10, -17, TNFα, and allelic polymorphisms of their genes in 62 patients with B cell lymphoid malignancies in an ethnically homogenous group (self-identified as Russians. We have shown that the GА and AA genotypes of the G-308A polymorphism in TNFα gene are significantly associated with increased production of this cytokine, being more common in aggressive non-Hodgkin lymphomas, more rare in multiple myeloma and in indolent non-Hodgkin lymphomas.https://www.mimmun.ru/mimmun/article/view/729b-cell lymphoid malignanciesgene polymorphismcytokinescytokine receptors |
| spellingShingle | E. L. Nazarova V. I. Shardakov V. T. Demyanova T. P. Zagoskina E. N. Zotina EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES Медицинская иммунология b-cell lymphoid malignancies gene polymorphism cytokines cytokine receptors |
| title | EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES |
| title_full | EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES |
| title_fullStr | EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES |
| title_full_unstemmed | EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES |
| title_short | EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES |
| title_sort | evaluation of cytokine gene polymorphism in b cell lymphoid malignancies |
| topic | b-cell lymphoid malignancies gene polymorphism cytokines cytokine receptors |
| url | https://www.mimmun.ru/mimmun/article/view/729 |
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