A New Urease Inhibitor from Viola betonicifolia
Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of patholo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-10-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/19/10/16770 |
| _version_ | 1819072919613997056 |
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| author | Naveed Muhammad Muhammad Saeed Ajmal Khan Achyut Adhikari Abdul Wadood Khalid Mohammed Khan Vincenzo De Feo |
| author_facet | Naveed Muhammad Muhammad Saeed Ajmal Khan Achyut Adhikari Abdul Wadood Khalid Mohammed Khan Vincenzo De Feo |
| author_sort | Naveed Muhammad |
| collection | DOAJ |
| description | Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of pathologies induced by H. pylori, such as gastritis and peptic ulcer. In the present work, the new natural compound, 3-methoxydalbergione, was isolated from Viola betonicifolia. A mechanistic study of this compound as a natural urease inhibitor was performed by using enzyme kinetics and docking studies. 3-Methoxydalbergione could be considered as a lead molecule for drugs useful in the urease associated diseases. |
| first_indexed | 2024-12-21T17:45:23Z |
| format | Article |
| id | doaj.art-047215eef0234682b3ea759901b452bc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T17:45:23Z |
| publishDate | 2014-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-047215eef0234682b3ea759901b452bc2022-12-21T18:55:31ZengMDPI AGMolecules1420-30492014-10-011910167701677810.3390/molecules191016770molecules191016770A New Urease Inhibitor from Viola betonicifoliaNaveed Muhammad0Muhammad Saeed1Ajmal Khan2Achyut Adhikari3Abdul Wadood4Khalid Mohammed Khan5Vincenzo De Feo6Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, PakistanDepartment of Pharmacy, University of Peshawar, Peshawar 25120, PakistanResearch Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, PakistanResearch Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, PakistanComputational Medicinal Chemistry Laboratory, Department of Biochemistry, Shankar Campus, Abdul Wali Khan University, Mardan 23200, PakistanResearch Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, PakistanDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Salerno, ItalyUrease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of pathologies induced by H. pylori, such as gastritis and peptic ulcer. In the present work, the new natural compound, 3-methoxydalbergione, was isolated from Viola betonicifolia. A mechanistic study of this compound as a natural urease inhibitor was performed by using enzyme kinetics and docking studies. 3-Methoxydalbergione could be considered as a lead molecule for drugs useful in the urease associated diseases.http://www.mdpi.com/1420-3049/19/10/16770Viola betonicifoliaurease inhibitionkinetic studymolecular modeling |
| spellingShingle | Naveed Muhammad Muhammad Saeed Ajmal Khan Achyut Adhikari Abdul Wadood Khalid Mohammed Khan Vincenzo De Feo A New Urease Inhibitor from Viola betonicifolia Molecules Viola betonicifolia urease inhibition kinetic study molecular modeling |
| title | A New Urease Inhibitor from Viola betonicifolia |
| title_full | A New Urease Inhibitor from Viola betonicifolia |
| title_fullStr | A New Urease Inhibitor from Viola betonicifolia |
| title_full_unstemmed | A New Urease Inhibitor from Viola betonicifolia |
| title_short | A New Urease Inhibitor from Viola betonicifolia |
| title_sort | new urease inhibitor from viola betonicifolia |
| topic | Viola betonicifolia urease inhibition kinetic study molecular modeling |
| url | http://www.mdpi.com/1420-3049/19/10/16770 |
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