Rules of Oxidative Stress in Wound Healing
Wound healing is a complex dynamic process characterized by a series of events that occur in almost all type of tissue damage. In the early phase of the inflammatory response, neutrophils and macrophages enters into the injured tissue and the cells produce reactive oxygen species that can give a ben...
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| Format: | Article |
| Language: | English |
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Research and Community Service Department (LPPM) Universitas Wijaya Kusuma Surabaya
2018-03-01
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| Series: | Jurnal Ilmiah Kedokteran Wijaya Kusuma |
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| Online Access: | https://journal.uwks.ac.id/index.php/jikw/article/view/338 |
| _version_ | 1797725577865592832 |
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| author | Handy Arief |
| author_facet | Handy Arief |
| author_sort | Handy Arief |
| collection | DOAJ |
| description | Wound healing is a complex dynamic process characterized by a series of events that occur in almost all type of tissue damage. In the early phase of the inflammatory response, neutrophils and macrophages enters into the injured tissue and the cells produce reactive oxygen species that can give a beneficial or detrimental effects. Oxidative stress is a condition occurs that shows imbalance between prooxidant or free radical and antioxidant that have a function to maintain the condition of the tissue damage that occurs. So Oxidative stress occurs when the production of Reactive Oxygen Species occurring is higher than the antioxidants existing as an intrinsic defense. Reactive Oxygen Species and Reactive Nitrogen Species are important components in the healing process of wounds and is necessary to be in the state of homeostasis to prevent oksidatif stress. The major components of ROS are superoxide (O2•), hydroxyl radical (OH•) and hydrogen peroxide (H2O2), which includes RNS are nitric oxide (NO•), nitrous oxide (NO2•), nitroxyl anion (HNO) and peroxynitrite (ONOO-) which could be form by the reaction between superoxide and nitric oxide. The existence of excessive O2 amount in the wound and the presence of excess NO can increase the incidence of oxidative stress that interfere with wound healing process. Oxidative stress plays a role in the inflammatory phase, proliferation and remodeling phase by increasing angiogenesis and affect other cells including endothelial cells in secreting NO. So the strategy in controlling oxidative stress is by increasing antioxidant level which is a scavenger to free radical excessive superoxide formation so preventing interference with the wound healing process. |
| first_indexed | 2024-03-12T10:33:16Z |
| format | Article |
| id | doaj.art-04728b6620b54170add6b4b68961fed8 |
| institution | Directory Open Access Journal |
| issn | 1978-2071 2580-5967 |
| language | English |
| last_indexed | 2024-03-12T10:33:16Z |
| publishDate | 2018-03-01 |
| publisher | Research and Community Service Department (LPPM) Universitas Wijaya Kusuma Surabaya |
| record_format | Article |
| series | Jurnal Ilmiah Kedokteran Wijaya Kusuma |
| spelling | doaj.art-04728b6620b54170add6b4b68961fed82023-09-02T09:04:14ZengResearch and Community Service Department (LPPM) Universitas Wijaya Kusuma SurabayaJurnal Ilmiah Kedokteran Wijaya Kusuma1978-20712580-59672018-03-01522228312Rules of Oxidative Stress in Wound HealingHandy Arief0Bagian Ilmu Bedah, Fakultas Kedokteran, Universitas Wijaya Kusuma SurabayaWound healing is a complex dynamic process characterized by a series of events that occur in almost all type of tissue damage. In the early phase of the inflammatory response, neutrophils and macrophages enters into the injured tissue and the cells produce reactive oxygen species that can give a beneficial or detrimental effects. Oxidative stress is a condition occurs that shows imbalance between prooxidant or free radical and antioxidant that have a function to maintain the condition of the tissue damage that occurs. So Oxidative stress occurs when the production of Reactive Oxygen Species occurring is higher than the antioxidants existing as an intrinsic defense. Reactive Oxygen Species and Reactive Nitrogen Species are important components in the healing process of wounds and is necessary to be in the state of homeostasis to prevent oksidatif stress. The major components of ROS are superoxide (O2•), hydroxyl radical (OH•) and hydrogen peroxide (H2O2), which includes RNS are nitric oxide (NO•), nitrous oxide (NO2•), nitroxyl anion (HNO) and peroxynitrite (ONOO-) which could be form by the reaction between superoxide and nitric oxide. The existence of excessive O2 amount in the wound and the presence of excess NO can increase the incidence of oxidative stress that interfere with wound healing process. Oxidative stress plays a role in the inflammatory phase, proliferation and remodeling phase by increasing angiogenesis and affect other cells including endothelial cells in secreting NO. So the strategy in controlling oxidative stress is by increasing antioxidant level which is a scavenger to free radical excessive superoxide formation so preventing interference with the wound healing process.https://journal.uwks.ac.id/index.php/jikw/article/view/338Oxidative Stress, ROS, RNS, Antioxidant, Wound Healing. |
| spellingShingle | Handy Arief Rules of Oxidative Stress in Wound Healing Jurnal Ilmiah Kedokteran Wijaya Kusuma Oxidative Stress, ROS, RNS, Antioxidant, Wound Healing. |
| title | Rules of Oxidative Stress in Wound Healing |
| title_full | Rules of Oxidative Stress in Wound Healing |
| title_fullStr | Rules of Oxidative Stress in Wound Healing |
| title_full_unstemmed | Rules of Oxidative Stress in Wound Healing |
| title_short | Rules of Oxidative Stress in Wound Healing |
| title_sort | rules of oxidative stress in wound healing |
| topic | Oxidative Stress, ROS, RNS, Antioxidant, Wound Healing. |
| url | https://journal.uwks.ac.id/index.php/jikw/article/view/338 |
| work_keys_str_mv | AT handyarief rulesofoxidativestressinwoundhealing |