Altered Gut Microbiome in Parkinson’s Disease and the Influence of Lipopolysaccharide in a Human α-Synuclein Over-Expressing Mouse Model

Altered Gut Microbiome in Parkinson’s Disease and the Influence of Lipopolysaccharide in a Human α-Synuclein Over-Expressing Mouse Model

The interaction between the gut microbiota and alpha-synuclein (αSyn) aggregation in Parkinson’s disease (PD) is receiving increasing attention. The objective of this study was to investigate gut microbiota, and effects of an inflammatory lipopolysaccharide (LPS) trigger in a human αSyn over-express...

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Bibliographic Details
Main Authors: Anastazja M. Gorecki, Leah Preskey, Megan C. Bakeberg, Jade E. Kenna, Christi Gildenhuys, Gabriella MacDougall, Sarah A. Dunlop, Frank L. Mastaglia, P. Anthony Akkari, Frank Koengten, Ryan S. Anderton
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson’s disease
microbiome
lipopolysaccharide
Gammaproteobacteria
Thy1-αSyn
gastrointestinal
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00839/full

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