Excitatory amino acid b-N-methylamino-L-alanine is a putative environmental neurotoxin
The amino acid b-N-methylamino-L-alanine (L-BMAA) has been associated with the amyotrophic lateral sclerosis/parkinsonism-dementia complex in three distinct western Pacific populations. The putative neurotoxin is produced by cyanobacteria, which live symbiotically in the roots of cycad trees. L-BMAA...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2011-04-01
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| Series: | Journal of the Serbian Chemical Society |
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| Online Access: | http://www.shd.org.rs/JSCS/Vol76/No4/01_4834_4134.pdf |
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| author | VLADIMIR NEDELJKOV MILICA PROSTRAN DRAGAN PAVLOVIĆ PATHAK DHRUBA MARIJA BRATIĆ-STANOJEVIĆ SRDJAN LOPIČIĆ SRDJAN LOPIČIĆ MARIJA BRATIĆ-STANOJEVIĆ PATHAK DHRUBA DRAGAN PAVLOVIĆ MILICA PROSTRAN VLADIMIR NEDELJKOV |
| author_facet | VLADIMIR NEDELJKOV MILICA PROSTRAN DRAGAN PAVLOVIĆ PATHAK DHRUBA MARIJA BRATIĆ-STANOJEVIĆ SRDJAN LOPIČIĆ SRDJAN LOPIČIĆ MARIJA BRATIĆ-STANOJEVIĆ PATHAK DHRUBA DRAGAN PAVLOVIĆ MILICA PROSTRAN VLADIMIR NEDELJKOV |
| author_sort | VLADIMIR NEDELJKOV |
| collection | DOAJ |
| description | The amino acid b-N-methylamino-L-alanine (L-BMAA) has been associated with the amyotrophic lateral sclerosis/parkinsonism-dementia complex in three distinct western Pacific populations. The putative neurotoxin is produced by cyanobacteria, which live symbiotically in the roots of cycad trees. L-BMAA was thought to be a threat only to those few populations whose diet and medicines rely heavily on cycad seeds. However, the recent discovery that cyanobacteria from diverse terrestrial, freshwater, and saltwater ecosystems around the world produce the toxin requires a reassessment of whether it poses a larger health threat. Therefore, it is proposed that monitoring L-BMAA levels in cyanobacteria-contaminated water supplies might be prudent. |
| first_indexed | 2024-12-12T04:14:07Z |
| format | Article |
| id | doaj.art-04735dc419ae49c3a609e521f4c5a7fa |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-12T04:14:07Z |
| publishDate | 2011-04-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-04735dc419ae49c3a609e521f4c5a7fa2022-12-22T00:38:31ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392011-04-01764479490Excitatory amino acid b-N-methylamino-L-alanine is a putative environmental neurotoxinVLADIMIR NEDELJKOVMILICA PROSTRANDRAGAN PAVLOVIĆPATHAK DHRUBAMARIJA BRATIĆ-STANOJEVIĆSRDJAN LOPIČIĆSRDJAN LOPIČIĆMARIJA BRATIĆ-STANOJEVIĆPATHAK DHRUBADRAGAN PAVLOVIĆMILICA PROSTRANVLADIMIR NEDELJKOVThe amino acid b-N-methylamino-L-alanine (L-BMAA) has been associated with the amyotrophic lateral sclerosis/parkinsonism-dementia complex in three distinct western Pacific populations. The putative neurotoxin is produced by cyanobacteria, which live symbiotically in the roots of cycad trees. L-BMAA was thought to be a threat only to those few populations whose diet and medicines rely heavily on cycad seeds. However, the recent discovery that cyanobacteria from diverse terrestrial, freshwater, and saltwater ecosystems around the world produce the toxin requires a reassessment of whether it poses a larger health threat. Therefore, it is proposed that monitoring L-BMAA levels in cyanobacteria-contaminated water supplies might be prudent.http://www.shd.org.rs/JSCS/Vol76/No4/01_4834_4134.pdfb-N-methylamino-L-alanineneurodegenerative diseasesneurotoxicityenvironmental toxin |
| spellingShingle | VLADIMIR NEDELJKOV MILICA PROSTRAN DRAGAN PAVLOVIĆ PATHAK DHRUBA MARIJA BRATIĆ-STANOJEVIĆ SRDJAN LOPIČIĆ SRDJAN LOPIČIĆ MARIJA BRATIĆ-STANOJEVIĆ PATHAK DHRUBA DRAGAN PAVLOVIĆ MILICA PROSTRAN VLADIMIR NEDELJKOV Excitatory amino acid b-N-methylamino-L-alanine is a putative environmental neurotoxin Journal of the Serbian Chemical Society b-N-methylamino-L-alanine neurodegenerative diseases neurotoxicity environmental toxin |
| title | Excitatory amino acid b-N-methylamino-L-alanine is a putative environmental neurotoxin |
| title_full | Excitatory amino acid b-N-methylamino-L-alanine is a putative environmental neurotoxin |
| title_fullStr | Excitatory amino acid b-N-methylamino-L-alanine is a putative environmental neurotoxin |
| title_full_unstemmed | Excitatory amino acid b-N-methylamino-L-alanine is a putative environmental neurotoxin |
| title_short | Excitatory amino acid b-N-methylamino-L-alanine is a putative environmental neurotoxin |
| title_sort | excitatory amino acid b n methylamino l alanine is a putative environmental neurotoxin |
| topic | b-N-methylamino-L-alanine neurodegenerative diseases neurotoxicity environmental toxin |
| url | http://www.shd.org.rs/JSCS/Vol76/No4/01_4834_4134.pdf |
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