Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35
Six new polyketides, which includes three new lactones (talarotones A–C) (1–3), one new polyketide (talarotide A) (4), two new polyenes (talaroyenes A, B) (5, 6), together with one new meroterpenoid (talaropenoid A) (7) and 13 known compounds (8–20) were isolated from the mangrove-derived fungus Tal...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1342843/full |
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| author | Jin Cai Jin Cai Xueming Zhou Xueming Zhou Bin Wang Bin Wang Xuelong Zhang Xuelong Zhang Mengyao Luo Mengyao Luo Longtao Huang Longtao Huang Ruoxi Wang Ruoxi Wang Yonghao Chen Yonghao Chen Xiaoyang Li Xiaoyang Li Youping Luo Youping Luo Guangying Chen Guangying Chen Fei Cao Guolei Huang Guolei Huang Caijuan Zheng Caijuan Zheng |
| author_facet | Jin Cai Jin Cai Xueming Zhou Xueming Zhou Bin Wang Bin Wang Xuelong Zhang Xuelong Zhang Mengyao Luo Mengyao Luo Longtao Huang Longtao Huang Ruoxi Wang Ruoxi Wang Yonghao Chen Yonghao Chen Xiaoyang Li Xiaoyang Li Youping Luo Youping Luo Guangying Chen Guangying Chen Fei Cao Guolei Huang Guolei Huang Caijuan Zheng Caijuan Zheng |
| author_sort | Jin Cai |
| collection | DOAJ |
| description | Six new polyketides, which includes three new lactones (talarotones A–C) (1–3), one new polyketide (talarotide A) (4), two new polyenes (talaroyenes A, B) (5, 6), together with one new meroterpenoid (talaropenoid A) (7) and 13 known compounds (8–20) were isolated from the mangrove-derived fungus Talaromyces flavus TGGP35. The structure and configuration of the compounds 1–7 were elucidated from the data obtained from HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo2 (OAc)4-induced electronic circular dichroism (ECD), CD spectroscopy, and modified Mosher's method. Compounds 5 and 20 displayed antioxidant activity with IC50 values of 0.40 and 1.36 mM, respectively. Compounds 3, 6, 11, 16, and 17 displayed cytotoxic activity against human cancer cells Hela, A549, and had IC50 values ranging from 28.89 to 62.23 μM. Compounds 7, 10–12, and 14–18 exhibited moderate or potent anti-insect activity against newly hatched larvae of Helicoverpa armigera Hubner, with IC50 values in the range 50–200 μg/mL. Compound 18 showed antibacterial activity against Ralstonia solanacearum with the MIC value of 50 μg/mL. |
| first_indexed | 2024-03-08T09:06:03Z |
| format | Article |
| id | doaj.art-0474afbbc648482bbbf630f0378a84d3 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-08T09:06:03Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-0474afbbc648482bbbf630f0378a84d32024-02-01T04:37:31ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-02-011510.3389/fmicb.2024.13428431342843Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35Jin Cai0Jin Cai1Xueming Zhou2Xueming Zhou3Bin Wang4Bin Wang5Xuelong Zhang6Xuelong Zhang7Mengyao Luo8Mengyao Luo9Longtao Huang10Longtao Huang11Ruoxi Wang12Ruoxi Wang13Yonghao Chen14Yonghao Chen15Xiaoyang Li16Xiaoyang Li17Youping Luo18Youping Luo19Guangying Chen20Guangying Chen21Fei Cao22Guolei Huang23Guolei Huang24Caijuan Zheng25Caijuan Zheng26Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaKey Laboratory of Pharmaceutical Quality Control of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, College of Pharmaceutical Sciences, Hebei University, Baoding, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, ChinaSix new polyketides, which includes three new lactones (talarotones A–C) (1–3), one new polyketide (talarotide A) (4), two new polyenes (talaroyenes A, B) (5, 6), together with one new meroterpenoid (talaropenoid A) (7) and 13 known compounds (8–20) were isolated from the mangrove-derived fungus Talaromyces flavus TGGP35. The structure and configuration of the compounds 1–7 were elucidated from the data obtained from HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo2 (OAc)4-induced electronic circular dichroism (ECD), CD spectroscopy, and modified Mosher's method. Compounds 5 and 20 displayed antioxidant activity with IC50 values of 0.40 and 1.36 mM, respectively. Compounds 3, 6, 11, 16, and 17 displayed cytotoxic activity against human cancer cells Hela, A549, and had IC50 values ranging from 28.89 to 62.23 μM. Compounds 7, 10–12, and 14–18 exhibited moderate or potent anti-insect activity against newly hatched larvae of Helicoverpa armigera Hubner, with IC50 values in the range 50–200 μg/mL. Compound 18 showed antibacterial activity against Ralstonia solanacearum with the MIC value of 50 μg/mL.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1342843/fullTalaromyces flavuspolyketidelactonesmeroterpenoidbioactivities |
| spellingShingle | Jin Cai Jin Cai Xueming Zhou Xueming Zhou Bin Wang Bin Wang Xuelong Zhang Xuelong Zhang Mengyao Luo Mengyao Luo Longtao Huang Longtao Huang Ruoxi Wang Ruoxi Wang Yonghao Chen Yonghao Chen Xiaoyang Li Xiaoyang Li Youping Luo Youping Luo Guangying Chen Guangying Chen Fei Cao Guolei Huang Guolei Huang Caijuan Zheng Caijuan Zheng Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35 Frontiers in Microbiology Talaromyces flavus polyketide lactones meroterpenoid bioactivities |
| title | Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35 |
| title_full | Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35 |
| title_fullStr | Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35 |
| title_full_unstemmed | Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35 |
| title_short | Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35 |
| title_sort | bioactive polyketides and meroterpenoids from the mangrove derived fungus talaromyces flavus tggp35 |
| topic | Talaromyces flavus polyketide lactones meroterpenoid bioactivities |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1342843/full |
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