Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice
The Notch signaling pathway is an important conserved pathway for normal homeostasis during development. However, targeted deletion of Notch4 (Notch4d1) or Notch3 (Notch3d1) in mice is not lethal. In fact, both Notch4d1 and Notch3d1 mice develop normally and are fertile. Here we present RNA seq anal...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | Data in Brief |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340921001578 |
| _version_ | 1818607335865581568 |
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| author | Madhulika Sharma Sireesha Yerrathota Mackenzie M Thornton Sumedha Gunewardena |
| author_facet | Madhulika Sharma Sireesha Yerrathota Mackenzie M Thornton Sumedha Gunewardena |
| author_sort | Madhulika Sharma |
| collection | DOAJ |
| description | The Notch signaling pathway is an important conserved pathway for normal homeostasis during development. However, targeted deletion of Notch4 (Notch4d1) or Notch3 (Notch3d1) in mice is not lethal. In fact, both Notch4d1 and Notch3d1 mice develop normally and are fertile. Here we present RNA seq analysis of differential gene expression in the kidneys of Notch4d1 mice versus the Notch3d1 mice, all on FVB background. Kidneys were collected from Notch4d1 and Notch3d1 littermates at 3 months of age. RNA sequencing was carried out. The raw data were analyzed for differential gene expression using a negative binomial generalized linear model in the DeSeq2 software package. We used P-value ≤0.05 and an absolute fold change of 1.5 or greater to identify top upregulated and downregulated genes in Notch4d1 mice compared to Notch3d1 mice. The data provided will indentify targets of Notch3 and Notch4 signaling, specifically in kidney diseases where Notch3 or Notch4 are abberantly or redundantly expressed. |
| first_indexed | 2024-12-16T14:25:07Z |
| format | Article |
| id | doaj.art-0475282d66d44af0864b1dfa75b7c5fd |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-16T14:25:07Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-0475282d66d44af0864b1dfa75b7c5fd2022-12-21T22:28:23ZengElsevierData in Brief2352-34092021-04-0135106873Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted miceMadhulika Sharma0Sireesha Yerrathota1Mackenzie M Thornton2Sumedha Gunewardena3Departments of Internal Medicine, United States; The Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, KS, United States; Corresponding author at: Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160.Departments of Internal Medicine, United States; The Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, KS, United StatesDepartments of Internal Medicine, United States; The Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, KS, United StatesMolecular and integrative physiology, United StatesThe Notch signaling pathway is an important conserved pathway for normal homeostasis during development. However, targeted deletion of Notch4 (Notch4d1) or Notch3 (Notch3d1) in mice is not lethal. In fact, both Notch4d1 and Notch3d1 mice develop normally and are fertile. Here we present RNA seq analysis of differential gene expression in the kidneys of Notch4d1 mice versus the Notch3d1 mice, all on FVB background. Kidneys were collected from Notch4d1 and Notch3d1 littermates at 3 months of age. RNA sequencing was carried out. The raw data were analyzed for differential gene expression using a negative binomial generalized linear model in the DeSeq2 software package. We used P-value ≤0.05 and an absolute fold change of 1.5 or greater to identify top upregulated and downregulated genes in Notch4d1 mice compared to Notch3d1 mice. The data provided will indentify targets of Notch3 and Notch4 signaling, specifically in kidney diseases where Notch3 or Notch4 are abberantly or redundantly expressed.http://www.sciencedirect.com/science/article/pii/S2352340921001578HIVANChronic kidney diseaseInflammationTg26 |
| spellingShingle | Madhulika Sharma Sireesha Yerrathota Mackenzie M Thornton Sumedha Gunewardena Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice Data in Brief HIVAN Chronic kidney disease Inflammation Tg26 |
| title | Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice |
| title_full | Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice |
| title_fullStr | Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice |
| title_full_unstemmed | Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice |
| title_short | Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice |
| title_sort | transcriptomic data showing differentially expressed genes between notch3 and notch4 deleted mice |
| topic | HIVAN Chronic kidney disease Inflammation Tg26 |
| url | http://www.sciencedirect.com/science/article/pii/S2352340921001578 |
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