ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer

ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer

Abstract Background Small cell lung cancer (SCLC) is a more aggressive subtype of lung cancer that often results in rapid tumor growth, early metastasis, and acquired therapeutic resistance. Consequently, such phenotypical characteristics of SCLC set limitations on viable procedural options, making...

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Bibliographic Details
Main Authors: Aileen Patricia Szczepanski, Zibo Zhao, Tori Sosnowski, Young Ah Goo, Elizabeth Thomas Bartom, Lu Wang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Genome Medicine
Subjects:
ASXL3
BAP1 complex
BRD4
SCLC
Enhancer activity
BET inhibitors
Online Access:http://link.springer.com/article/10.1186/s13073-020-00760-3

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