The functional state of the kallikrein-kinin and renin-angiotensin-aldosterone systems in patients with localized kidney cancer
Introduction. The development of a malignant tumor naturally affects renal function. During tumor formation, the renal tissue is destructed either by direct invasion into the parenchyma, or by mechanical change in the renal architecture caused by compression of the renal parenchyma, collecting ducts...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Ministry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional Education
2021-12-01
|
| Series: | Вестник урологии |
| Subjects: | |
| Online Access: | https://www.urovest.ru/jour/article/view/506 |
| _version_ | 1826565451054841856 |
|---|---|
| author | N. D. Ushakova E. M. Frantsiyants D. A. Rozenko N. N. Popova E. A. Marykov A. D. Rozenko |
| author_facet | N. D. Ushakova E. M. Frantsiyants D. A. Rozenko N. N. Popova E. A. Marykov A. D. Rozenko |
| author_sort | N. D. Ushakova |
| collection | DOAJ |
| description | Introduction. The development of a malignant tumor naturally affects renal function. During tumor formation, the renal tissue is destructed either by direct invasion into the parenchyma, or by mechanical change in the renal architecture caused by compression of the renal parenchyma, collecting ducts, tubules, and nephrons. In addition, a tumor can secrete biologically active substances, which have an indirect negative influence the functional state of the organ. Currently, it has been established that kallikrein-kinin and renin-angiotensin-aldosterone systems play an important role in the development of nephropathy of various genesis. At the same time, these systems' role in the development of renal function disorders in the setting of tumor damage has not yet been studied.Purpose of the study. To study changes in the components of the kallikrein-kinin and renin-angiotensin-aldosterone systems in the case of localized kidney cancer.Materials and methods. Forty-five patients diagnosed with T1N0M0 kidney cancer and 13 relatively healthy patients without cancer were examined. The determination of the components of the systems under study was carried out by the kinetic method after chromatography of blood plasma and urine using DEAE-Sephadex A-50 (Amersham Biosciences Corp., Sweden). The indices of angiotensin-1, renin, aldosterone, and cortisol were studied by an indirect method of radioimmunoassay. Statistical processing was carried out using Statistica 8.0 software (StatSoft Inc., IBM Corp., USA) by means of the Student-Fisher test (p < 0.05).Results. The development of kidney cancer is accompanied by a 2.3-fold increase in the activity of kallikrein and other trypsin proteases with a significant deficiency of their inhibitors (p < 0,05). Against this background, there is a 1.3-fold decrease in the cortisol/renin ratio from a 2.9-fold and 2.3-fold increase in the values of the renin/angiotensin-I and cortisol/angiotensin-I interaction ratios, respectively, compared with the normal values of these indicators (p < 0,05).Conclusions. Renal cell carcinoma is accompanied by trespassing of local metabolism with the formation of tubulointerstitial dysfunction and a shift of the proteinase-inhibitory balance towards proteolytic activation. |
| first_indexed | 2024-03-07T14:22:54Z |
| format | Article |
| id | doaj.art-04767ad179bb45f6baf1c83d008b4813 |
| institution | Directory Open Access Journal |
| issn | 2308-6424 |
| language | Russian |
| last_indexed | 2025-03-14T10:35:57Z |
| publishDate | 2021-12-01 |
| publisher | Ministry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional Education |
| record_format | Article |
| series | Вестник урологии |
| spelling | doaj.art-04767ad179bb45f6baf1c83d008b48132025-03-02T10:59:28ZrusMinistry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional EducationВестник урологии2308-64242021-12-019410111010.21886/2308-6424-2021-9-4-101-110348The functional state of the kallikrein-kinin and renin-angiotensin-aldosterone systems in patients with localized kidney cancerN. D. Ushakova0E. M. Frantsiyants1D. A. Rozenko2N. N. Popova3E. A. Marykov4A. D. Rozenko5National Medical Research Centre for Oncology; Rostov State Medical UniversityNational Medical Research Centre for OncologyNational Medical Research Centre for OncologyNational Medical Research Centre for Oncology; Rostov State Medical UniversityNational Medical Research Centre for OncologyRostov State Medical UniversityIntroduction. The development of a malignant tumor naturally affects renal function. During tumor formation, the renal tissue is destructed either by direct invasion into the parenchyma, or by mechanical change in the renal architecture caused by compression of the renal parenchyma, collecting ducts, tubules, and nephrons. In addition, a tumor can secrete biologically active substances, which have an indirect negative influence the functional state of the organ. Currently, it has been established that kallikrein-kinin and renin-angiotensin-aldosterone systems play an important role in the development of nephropathy of various genesis. At the same time, these systems' role in the development of renal function disorders in the setting of tumor damage has not yet been studied.Purpose of the study. To study changes in the components of the kallikrein-kinin and renin-angiotensin-aldosterone systems in the case of localized kidney cancer.Materials and methods. Forty-five patients diagnosed with T1N0M0 kidney cancer and 13 relatively healthy patients without cancer were examined. The determination of the components of the systems under study was carried out by the kinetic method after chromatography of blood plasma and urine using DEAE-Sephadex A-50 (Amersham Biosciences Corp., Sweden). The indices of angiotensin-1, renin, aldosterone, and cortisol were studied by an indirect method of radioimmunoassay. Statistical processing was carried out using Statistica 8.0 software (StatSoft Inc., IBM Corp., USA) by means of the Student-Fisher test (p < 0.05).Results. The development of kidney cancer is accompanied by a 2.3-fold increase in the activity of kallikrein and other trypsin proteases with a significant deficiency of their inhibitors (p < 0,05). Against this background, there is a 1.3-fold decrease in the cortisol/renin ratio from a 2.9-fold and 2.3-fold increase in the values of the renin/angiotensin-I and cortisol/angiotensin-I interaction ratios, respectively, compared with the normal values of these indicators (p < 0,05).Conclusions. Renal cell carcinoma is accompanied by trespassing of local metabolism with the formation of tubulointerstitial dysfunction and a shift of the proteinase-inhibitory balance towards proteolytic activation.https://www.urovest.ru/jour/article/view/506kallikrein-kinin systemrenin-angiotensin-aldosterone systemlocalized kidney cancer |
| spellingShingle | N. D. Ushakova E. M. Frantsiyants D. A. Rozenko N. N. Popova E. A. Marykov A. D. Rozenko The functional state of the kallikrein-kinin and renin-angiotensin-aldosterone systems in patients with localized kidney cancer Вестник урологии kallikrein-kinin system renin-angiotensin-aldosterone system localized kidney cancer |
| title | The functional state of the kallikrein-kinin and renin-angiotensin-aldosterone systems in patients with localized kidney cancer |
| title_full | The functional state of the kallikrein-kinin and renin-angiotensin-aldosterone systems in patients with localized kidney cancer |
| title_fullStr | The functional state of the kallikrein-kinin and renin-angiotensin-aldosterone systems in patients with localized kidney cancer |
| title_full_unstemmed | The functional state of the kallikrein-kinin and renin-angiotensin-aldosterone systems in patients with localized kidney cancer |
| title_short | The functional state of the kallikrein-kinin and renin-angiotensin-aldosterone systems in patients with localized kidney cancer |
| title_sort | functional state of the kallikrein kinin and renin angiotensin aldosterone systems in patients with localized kidney cancer |
| topic | kallikrein-kinin system renin-angiotensin-aldosterone system localized kidney cancer |
| url | https://www.urovest.ru/jour/article/view/506 |
| work_keys_str_mv | AT ndushakova thefunctionalstateofthekallikreinkininandreninangiotensinaldosteronesystemsinpatientswithlocalizedkidneycancer AT emfrantsiyants thefunctionalstateofthekallikreinkininandreninangiotensinaldosteronesystemsinpatientswithlocalizedkidneycancer AT darozenko thefunctionalstateofthekallikreinkininandreninangiotensinaldosteronesystemsinpatientswithlocalizedkidneycancer AT nnpopova thefunctionalstateofthekallikreinkininandreninangiotensinaldosteronesystemsinpatientswithlocalizedkidneycancer AT eamarykov thefunctionalstateofthekallikreinkininandreninangiotensinaldosteronesystemsinpatientswithlocalizedkidneycancer AT adrozenko thefunctionalstateofthekallikreinkininandreninangiotensinaldosteronesystemsinpatientswithlocalizedkidneycancer AT ndushakova functionalstateofthekallikreinkininandreninangiotensinaldosteronesystemsinpatientswithlocalizedkidneycancer AT emfrantsiyants functionalstateofthekallikreinkininandreninangiotensinaldosteronesystemsinpatientswithlocalizedkidneycancer AT darozenko functionalstateofthekallikreinkininandreninangiotensinaldosteronesystemsinpatientswithlocalizedkidneycancer AT nnpopova functionalstateofthekallikreinkininandreninangiotensinaldosteronesystemsinpatientswithlocalizedkidneycancer AT eamarykov functionalstateofthekallikreinkininandreninangiotensinaldosteronesystemsinpatientswithlocalizedkidneycancer AT adrozenko functionalstateofthekallikreinkininandreninangiotensinaldosteronesystemsinpatientswithlocalizedkidneycancer |