Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey
No gene has garnered more interest than p53 since its discovery over 40 years ago. In the last two decades, thanks to seminal work from Uri Alon and Ghalit Lahav, p53 has defined a truly synergistic topic in the field of mathematical biology, with a rich body of research connecting mathematic endeav...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/19/10590 |
| _version_ | 1797516243418218496 |
|---|---|
| author | Ján Eliaš Cicely K. Macnamara |
| author_facet | Ján Eliaš Cicely K. Macnamara |
| author_sort | Ján Eliaš |
| collection | DOAJ |
| description | No gene has garnered more interest than p53 since its discovery over 40 years ago. In the last two decades, thanks to seminal work from Uri Alon and Ghalit Lahav, p53 has defined a truly synergistic topic in the field of mathematical biology, with a rich body of research connecting mathematic endeavour with experimental design and data. In this review we survey and distill the extensive literature of mathematical models of p53. Specifically, we focus on models which seek to reproduce the oscillatory dynamics of p53 in response to DNA damage. We review the standard modelling approaches used in the field categorising them into three types: time delay models, spatial models and coupled negative-positive feedback models, providing sample model equations and simulation results which show clear oscillatory dynamics. We discuss the interplay between mathematics and biology and show how one informs the other; the deep connections between the two disciplines has helped to develop our understanding of this complex gene and paint a picture of its dynamical response. Although yet more is to be elucidated, we offer the current state-of-the-art understanding of p53 response to DNA damage. |
| first_indexed | 2024-03-10T06:58:31Z |
| format | Article |
| id | doaj.art-0477296a819642939bcff81522a470d6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:58:31Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0477296a819642939bcff81522a470d62023-11-22T16:12:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-0122191059010.3390/ijms221910590Mathematical Modelling of p53 Signalling during DNA Damage Response: A SurveyJán Eliaš0Cicely K. Macnamara1Institute of Mathematics and Scientific Computing, University of Graz, Heinrichstrasse 36, 8010 Graz, AustriaSchool of Mathematics and Statistics, Mathematical Institute, University of St Andrews, St Andrews KY16 9SS, UKNo gene has garnered more interest than p53 since its discovery over 40 years ago. In the last two decades, thanks to seminal work from Uri Alon and Ghalit Lahav, p53 has defined a truly synergistic topic in the field of mathematical biology, with a rich body of research connecting mathematic endeavour with experimental design and data. In this review we survey and distill the extensive literature of mathematical models of p53. Specifically, we focus on models which seek to reproduce the oscillatory dynamics of p53 in response to DNA damage. We review the standard modelling approaches used in the field categorising them into three types: time delay models, spatial models and coupled negative-positive feedback models, providing sample model equations and simulation results which show clear oscillatory dynamics. We discuss the interplay between mathematics and biology and show how one informs the other; the deep connections between the two disciplines has helped to develop our understanding of this complex gene and paint a picture of its dynamical response. Although yet more is to be elucidated, we offer the current state-of-the-art understanding of p53 response to DNA damage.https://www.mdpi.com/1422-0067/22/19/10590p53 modelsoscillatory dynamicsnegative feedbacktime delaysspatial modelspositive feedback |
| spellingShingle | Ján Eliaš Cicely K. Macnamara Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey International Journal of Molecular Sciences p53 models oscillatory dynamics negative feedback time delays spatial models positive feedback |
| title | Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey |
| title_full | Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey |
| title_fullStr | Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey |
| title_full_unstemmed | Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey |
| title_short | Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey |
| title_sort | mathematical modelling of p53 signalling during dna damage response a survey |
| topic | p53 models oscillatory dynamics negative feedback time delays spatial models positive feedback |
| url | https://www.mdpi.com/1422-0067/22/19/10590 |
| work_keys_str_mv | AT janelias mathematicalmodellingofp53signallingduringdnadamageresponseasurvey AT cicelykmacnamara mathematicalmodellingofp53signallingduringdnadamageresponseasurvey |