5 Fluorouracil‐loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cell
In this study, green synthesis of gold nanoparticles (AuNPs) was performed by a sunlight irradiation method using the Borassus flabellifer fruit extract as a reducing agent. 5‐Fluorouracil (5‐FU)‐loaded GG capped AuNPs (5FU‐G‐AuNPs) was prepared. The nanoparticles was further characterised by UV‐vis...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi-IET
2019-10-01
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| Series: | IET Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1049/iet-nbt.2019.0007 |
| _version_ | 1797414424201396224 |
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| author | Senthil Kumar Chinnaiyan Agnes Mary Soloman Ramesh Kannan Perumal Arun Gopinath Madhan Balaraman |
| author_facet | Senthil Kumar Chinnaiyan Agnes Mary Soloman Ramesh Kannan Perumal Arun Gopinath Madhan Balaraman |
| author_sort | Senthil Kumar Chinnaiyan |
| collection | DOAJ |
| description | In this study, green synthesis of gold nanoparticles (AuNPs) was performed by a sunlight irradiation method using the Borassus flabellifer fruit extract as a reducing agent. 5‐Fluorouracil (5‐FU)‐loaded GG capped AuNPs (5FU‐G‐AuNPs) was prepared. The nanoparticles was further characterised by UV‐visible spectra, particle size analysis, zeta potential, SAED, HRTEM, and XRD. The MTT assay results showed the suitability 5‐FU‐G‐AuNPs. In this study, 5‐FU‐G‐AuNPs exhibited potential cytotoxic and apoptotic effects on (MiaPaCa‐2) cell line. |
| first_indexed | 2024-03-09T05:32:51Z |
| format | Article |
| id | doaj.art-0477ed270ad1496a929cd825185d5db1 |
| institution | Directory Open Access Journal |
| issn | 1751-8741 1751-875X |
| language | English |
| last_indexed | 2024-03-09T05:32:51Z |
| publishDate | 2019-10-01 |
| publisher | Hindawi-IET |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj.art-0477ed270ad1496a929cd825185d5db12023-12-03T12:30:51ZengHindawi-IETIET Nanobiotechnology1751-87411751-875X2019-10-0113882482810.1049/iet-nbt.2019.00075 Fluorouracil‐loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cellSenthil Kumar Chinnaiyan0Agnes Mary Soloman1Ramesh Kannan Perumal2Arun Gopinath3Madhan Balaraman4CSIR‐Central Leather Research InstituteChennai600 020Tamil NaduIndiaCSIR‐Central Leather Research InstituteChennai600 020Tamil NaduIndiaCSIR‐Central Leather Research InstituteChennai600 020Tamil NaduIndiaCSIR‐Central Leather Research InstituteChennai600 020Tamil NaduIndiaCSIR‐Central Leather Research InstituteChennai600 020Tamil NaduIndiaIn this study, green synthesis of gold nanoparticles (AuNPs) was performed by a sunlight irradiation method using the Borassus flabellifer fruit extract as a reducing agent. 5‐Fluorouracil (5‐FU)‐loaded GG capped AuNPs (5FU‐G‐AuNPs) was prepared. The nanoparticles was further characterised by UV‐visible spectra, particle size analysis, zeta potential, SAED, HRTEM, and XRD. The MTT assay results showed the suitability 5‐FU‐G‐AuNPs. In this study, 5‐FU‐G‐AuNPs exhibited potential cytotoxic and apoptotic effects on (MiaPaCa‐2) cell line.https://doi.org/10.1049/iet-nbt.2019.00075FU‐G‐AuNPssuitability 5‐FU‐G‐AuNPshuman pancreatic cancer cellgreen synthesissunlight irradiation method5‐Fluorouracil‐loaded GG |
| spellingShingle | Senthil Kumar Chinnaiyan Agnes Mary Soloman Ramesh Kannan Perumal Arun Gopinath Madhan Balaraman 5 Fluorouracil‐loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cell IET Nanobiotechnology 5FU‐G‐AuNPs suitability 5‐FU‐G‐AuNPs human pancreatic cancer cell green synthesis sunlight irradiation method 5‐Fluorouracil‐loaded GG |
| title | 5 Fluorouracil‐loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cell |
| title_full | 5 Fluorouracil‐loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cell |
| title_fullStr | 5 Fluorouracil‐loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cell |
| title_full_unstemmed | 5 Fluorouracil‐loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cell |
| title_short | 5 Fluorouracil‐loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cell |
| title_sort | 5 fluorouracil loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cell |
| topic | 5FU‐G‐AuNPs suitability 5‐FU‐G‐AuNPs human pancreatic cancer cell green synthesis sunlight irradiation method 5‐Fluorouracil‐loaded GG |
| url | https://doi.org/10.1049/iet-nbt.2019.0007 |
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