Efficient Access to 3,5-Disubstituted 7-(Trifluoromethyl)pyrazolo[1,5-<i>a</i>]pyrimidines Involving S<i><sub>N</sub></i>Ar and Suzuki Cross-Coupling Reactions

Efficient Access to 3,5-Disubstituted 7-(Trifluoromethyl)pyrazolo[1,5-<i>a</i>]pyrimidines Involving S<i><sub>N</sub></i>Ar and Suzuki Cross-Coupling Reactions

An efficient and original synthesis of various 3,5-disubstituted 7-(trifluoromethyl)pyrazolo[1,5-<i>a</i>]pyrimidines is reported. A library of compounds diversely substituted in C-3 and C-5 positions was easily prepared from a common starting material, 3-bromo-7-(trifluoromethyl)pyrazol...

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Bibliographic Details
Main Authors:	Badr Jismy, Abdellatif Tikad, Mohamed Akssira, Gérald Guillaumet, Mohamed Abarbri
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Series:	Molecules
Subjects:	3-amino-1<i>H</i>-pyrazole ethyl 4,4,4-trifluoro-2-butynoate 3-bromo-7-(trifluoromethyl)pyrazolo[1,5-<i>a</i>]pyrimidin-5-one C–O bond activation Suzuki–Miyaura cross-coupling
Online Access:	https://www.mdpi.com/1420-3049/25/9/2062

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