De-Glycyrrhizinated Licorice Extract Attenuates High Glucose-Stimulated Renal Tubular Epithelial–Mesenchymal Transition via Suppressing the Notch2 Signaling Pathway

De-Glycyrrhizinated Licorice Extract Attenuates High Glucose-Stimulated Renal Tubular Epithelial–Mesenchymal Transition via Suppressing the Notch2 Signaling Pathway

Tubulointerstitial fibrosis is a major pathological hallmark of diabetic nephropathy. Increasing evidence has shown that epithelial-to-mesenchymal transition (EMT) of renal proximal tubular cells plays a crucial role in tubulointerstitial fibrosis. Herein, we aimed to elucidate the detailed mechanis...

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Bibliographic Details
Main Authors: Yung-Chien Hsu, Pey-Jium Chang, Chun-Wu Tung, Ya-Hsueh Shih, Wen-Chiu Ni, Yi-Chen Li, Takuhiro Uto, Yukihiro Shoyama, Cheng Ho, Chun-Liang Lin
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
diabetic nephropathy
renal fibrosis
renal tubular epithelial cells
emt
notch2
licorice
glycyrrhizin
de-glycyrrhizinated licorice
Online Access:https://www.mdpi.com/2073-4409/9/1/125

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