The ratio of the seroprevalence to the egg-positive prevalence of Schistosoma japonicum in China: a meta-analysis
Abstract Background Schistosomiasis, caused by Schistosoma japonicum, remains one of the most important parasitic diseases, and detection of S. japonicum infections in humans plays a crucial role in control and treatment. However, comparisons between the parasitological and the immunological examina...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-018-3320-5 |
| _version_ | 1828961568676642816 |
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| author | Yao Deng Chen Qiu Huan Ding Da-Bing Lu |
| author_facet | Yao Deng Chen Qiu Huan Ding Da-Bing Lu |
| author_sort | Yao Deng |
| collection | DOAJ |
| description | Abstract Background Schistosomiasis, caused by Schistosoma japonicum, remains one of the most important parasitic diseases, and detection of S. japonicum infections in humans plays a crucial role in control and treatment. However, comparisons between the parasitological and the immunological examinations in the fields of China are lacking. Therefore we performed a meta-analysis to compare the seroprevalence of Schistosoma japonicum, as determined by IHA or ELISA, with coprological prevalence, as determined by Kato-Katz, and estimate the ratio of the serological to the egg-positive prevalence in order to evaluate the potential threat of egg-negative but worm-positive schistosomiasis. Methods Studies published up to July 2018 on the parasitological and immunological examinations of schistosomiasis in the fields of China were searched in five databases including CNKI, WanFang, VIP, PubMed and Web of Science. The ratio of the serological to the egg-positive prevalence and its 95%CI for each study were calculated, and then point estimates and their 95%CIs of pooled prevalence ratio were meta-analyzed. Subgroup meta-analyses were also performed according to potential influential factors. Results A total of 23 articles were included. The prevalence ratio varied from 0.57 to 48.83 for IHA to Kato-Katz and ranged from 0.38 to 13.97 for ELISA to Kato-Katz. The pooled ratio was 4.72 (95%CI: 3.87~ 5.76) for IHA to KK and 4.65 (95%CI: 3.50~ 6.17) for ELISA to KK. Subgroup analyses implied that the ratio of the serological to the egg-positive prevalence may decrease with the endemic levels. The highest prevalence ratio was observed when Kato-Katz was performed with three slides per stool or in hilly and mountainous regions. Conclusions The worm-determined prevalence by IHA or ELISA is 4- to 5-fold higher than the egg-determined prevalence by Kato-Katz, which implied Kato-Katz may largely underestimate the prevalence of S. japonicum in China. The degree of underestimation was greater when Kato-Katz with three slides per stool was carried out, especially in low endemic areas or in hilly and mountainous regions. Therefore, more attention should be paid to those egg-negative but worm-positive patients with the aim of final elimination of S. japonicum in China. |
| first_indexed | 2024-12-14T09:47:41Z |
| format | Article |
| id | doaj.art-047fd0c67e6741e4930c594f144c3922 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-14T09:47:41Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
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| series | BMC Infectious Diseases |
| spelling | doaj.art-047fd0c67e6741e4930c594f144c39222022-12-21T23:07:35ZengBMCBMC Infectious Diseases1471-23342018-08-0118111210.1186/s12879-018-3320-5The ratio of the seroprevalence to the egg-positive prevalence of Schistosoma japonicum in China: a meta-analysisYao Deng0Chen Qiu1Huan Ding2Da-Bing Lu3Department of Epidemiology and Statistics, School of Public Health, Soochow UniversityDepartment of Epidemiology and Statistics, School of Public Health, Soochow UniversityDepartment of Epidemiology and Statistics, School of Public Health, Soochow UniversityDepartment of Epidemiology and Statistics, School of Public Health, Soochow UniversityAbstract Background Schistosomiasis, caused by Schistosoma japonicum, remains one of the most important parasitic diseases, and detection of S. japonicum infections in humans plays a crucial role in control and treatment. However, comparisons between the parasitological and the immunological examinations in the fields of China are lacking. Therefore we performed a meta-analysis to compare the seroprevalence of Schistosoma japonicum, as determined by IHA or ELISA, with coprological prevalence, as determined by Kato-Katz, and estimate the ratio of the serological to the egg-positive prevalence in order to evaluate the potential threat of egg-negative but worm-positive schistosomiasis. Methods Studies published up to July 2018 on the parasitological and immunological examinations of schistosomiasis in the fields of China were searched in five databases including CNKI, WanFang, VIP, PubMed and Web of Science. The ratio of the serological to the egg-positive prevalence and its 95%CI for each study were calculated, and then point estimates and their 95%CIs of pooled prevalence ratio were meta-analyzed. Subgroup meta-analyses were also performed according to potential influential factors. Results A total of 23 articles were included. The prevalence ratio varied from 0.57 to 48.83 for IHA to Kato-Katz and ranged from 0.38 to 13.97 for ELISA to Kato-Katz. The pooled ratio was 4.72 (95%CI: 3.87~ 5.76) for IHA to KK and 4.65 (95%CI: 3.50~ 6.17) for ELISA to KK. Subgroup analyses implied that the ratio of the serological to the egg-positive prevalence may decrease with the endemic levels. The highest prevalence ratio was observed when Kato-Katz was performed with three slides per stool or in hilly and mountainous regions. Conclusions The worm-determined prevalence by IHA or ELISA is 4- to 5-fold higher than the egg-determined prevalence by Kato-Katz, which implied Kato-Katz may largely underestimate the prevalence of S. japonicum in China. The degree of underestimation was greater when Kato-Katz with three slides per stool was carried out, especially in low endemic areas or in hilly and mountainous regions. Therefore, more attention should be paid to those egg-negative but worm-positive patients with the aim of final elimination of S. japonicum in China.http://link.springer.com/article/10.1186/s12879-018-3320-5Schistosoma japonicumKato-KatzIHAELISAPrevalence ratio |
| spellingShingle | Yao Deng Chen Qiu Huan Ding Da-Bing Lu The ratio of the seroprevalence to the egg-positive prevalence of Schistosoma japonicum in China: a meta-analysis BMC Infectious Diseases Schistosoma japonicum Kato-Katz IHA ELISA Prevalence ratio |
| title | The ratio of the seroprevalence to the egg-positive prevalence of Schistosoma japonicum in China: a meta-analysis |
| title_full | The ratio of the seroprevalence to the egg-positive prevalence of Schistosoma japonicum in China: a meta-analysis |
| title_fullStr | The ratio of the seroprevalence to the egg-positive prevalence of Schistosoma japonicum in China: a meta-analysis |
| title_full_unstemmed | The ratio of the seroprevalence to the egg-positive prevalence of Schistosoma japonicum in China: a meta-analysis |
| title_short | The ratio of the seroprevalence to the egg-positive prevalence of Schistosoma japonicum in China: a meta-analysis |
| title_sort | ratio of the seroprevalence to the egg positive prevalence of schistosoma japonicum in china a meta analysis |
| topic | Schistosoma japonicum Kato-Katz IHA ELISA Prevalence ratio |
| url | http://link.springer.com/article/10.1186/s12879-018-3320-5 |
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