Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System
Valerianaceae, the sub-family of Caprifoliaceae, contains more than 300 species of annual and perennial herbs, worldwide distributed. Several species are used for their biological properties while some are used as food. Species from the genus <i>Valeriana</i> have been used for their ant...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/10/5/846 |
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| author | Gitishree Das Han-Seung Shin Rosa Tundis Sandra Gonçalves Ourlad Alzeus G. Tantengco Maria G. Campos Rosaria Acquaviva Giuseppe Antonio Malfa Anabela Romano Joyce Ann H. Robles Mariel Q. Clores Jayanta-Kumar Patra |
| author_facet | Gitishree Das Han-Seung Shin Rosa Tundis Sandra Gonçalves Ourlad Alzeus G. Tantengco Maria G. Campos Rosaria Acquaviva Giuseppe Antonio Malfa Anabela Romano Joyce Ann H. Robles Mariel Q. Clores Jayanta-Kumar Patra |
| author_sort | Gitishree Das |
| collection | DOAJ |
| description | Valerianaceae, the sub-family of Caprifoliaceae, contains more than 300 species of annual and perennial herbs, worldwide distributed. Several species are used for their biological properties while some are used as food. Species from the genus <i>Valeriana</i> have been used for their antispasmodic, relaxing, and sedative properties, which have been mainly attributed to the presence of valepotriates, borneol derivatives, and isovalerenic acid. Among this genus, the most common and employed species is <i>Valeriana</i><i>officinalis</i>. Although valerian has been traditionally used as a mild sedative, research results are still controversial regarding the role of the different active compounds, the herbal preparations, and the dosage used. The present review is designed to summarize and critically describe the current knowledge on the different plant species belonging to Valerianaceae, their phytochemicals, their uses in the treatment of different diseases with particular emphasis on the effects on the central nervous system. The available information on this sub-family was collected from scientific databases up until year 2020. The following electronic databases were used: PubMed, Scopus, Sci Finder, Web of Science, Science Direct, NCBI, and Google Scholar. The search terms used for this review included Valerianaceae, <i>Valeriana</i>, <i>Centranthus</i>, <i>Fedia</i>, <i>Patrinia</i>, <i>Nardostachys</i>, <i>Plectritis</i>, and <i>Valerianella</i>, phytochemical composition, in vivo studies, Central Nervous System, neuroprotective, antidepressant, antinociceptive, anxiolytic, anxiety, preclinical and clinical studies. |
| first_indexed | 2024-03-10T12:04:22Z |
| format | Article |
| id | doaj.art-0480d125f7184e6c8ad20de748301b16 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T12:04:22Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-0480d125f7184e6c8ad20de748301b162023-11-21T16:41:09ZengMDPI AGPlants2223-77472021-04-0110584610.3390/plants10050846Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous SystemGitishree Das0Han-Seung Shin1Rosa Tundis2Sandra Gonçalves3Ourlad Alzeus G. Tantengco4Maria G. Campos5Rosaria Acquaviva6Giuseppe Antonio Malfa7Anabela Romano8Joyce Ann H. Robles9Mariel Q. Clores10Jayanta-Kumar Patra11Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyang-si 10326, KoreaDepartment of Food Science & Biotechnology, Dongguk University-Seoul, Goyang-si 10326, KoreaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Cosenza, ItalyMED—Mediterranean Institute for Agriculture, Environment and Development, Universidade do Algarve, Faculdade de Ciências e Tecnologia, Campus de Gambelas, Ed. 8, 8005-139 Faro, PortugalCollege of Medicine, University of the Philippines Manila, Manila 1000, PhilippinesObservatory of Drug-Herb Interactions, Faculty of Pharmacy, University of Coimbra, Heath Sciences Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalDepartment of Drug and Health Science—Biochemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, ItalyDepartment of Drug and Health Science—Biochemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, ItalyMED—Mediterranean Institute for Agriculture, Environment and Development, Universidade do Algarve, Faculdade de Ciências e Tecnologia, Campus de Gambelas, Ed. 8, 8005-139 Faro, PortugalCollege of Medicine, University of the Philippines Manila, Manila 1000, PhilippinesDepartment of Chemistry, University of Connecticut, Storrs, CT 06269, USAResearch Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyang-si 10326, KoreaValerianaceae, the sub-family of Caprifoliaceae, contains more than 300 species of annual and perennial herbs, worldwide distributed. Several species are used for their biological properties while some are used as food. Species from the genus <i>Valeriana</i> have been used for their antispasmodic, relaxing, and sedative properties, which have been mainly attributed to the presence of valepotriates, borneol derivatives, and isovalerenic acid. Among this genus, the most common and employed species is <i>Valeriana</i><i>officinalis</i>. Although valerian has been traditionally used as a mild sedative, research results are still controversial regarding the role of the different active compounds, the herbal preparations, and the dosage used. The present review is designed to summarize and critically describe the current knowledge on the different plant species belonging to Valerianaceae, their phytochemicals, their uses in the treatment of different diseases with particular emphasis on the effects on the central nervous system. The available information on this sub-family was collected from scientific databases up until year 2020. The following electronic databases were used: PubMed, Scopus, Sci Finder, Web of Science, Science Direct, NCBI, and Google Scholar. The search terms used for this review included Valerianaceae, <i>Valeriana</i>, <i>Centranthus</i>, <i>Fedia</i>, <i>Patrinia</i>, <i>Nardostachys</i>, <i>Plectritis</i>, and <i>Valerianella</i>, phytochemical composition, in vivo studies, Central Nervous System, neuroprotective, antidepressant, antinociceptive, anxiolytic, anxiety, preclinical and clinical studies.https://www.mdpi.com/2223-7747/10/5/846Valerianaceaeanxiolyticsedativemyorelaxantantidepressantbiological activities |
| spellingShingle | Gitishree Das Han-Seung Shin Rosa Tundis Sandra Gonçalves Ourlad Alzeus G. Tantengco Maria G. Campos Rosaria Acquaviva Giuseppe Antonio Malfa Anabela Romano Joyce Ann H. Robles Mariel Q. Clores Jayanta-Kumar Patra Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System Plants Valerianaceae anxiolytic sedative myorelaxant antidepressant biological activities |
| title | Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System |
| title_full | Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System |
| title_fullStr | Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System |
| title_full_unstemmed | Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System |
| title_short | Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System |
| title_sort | plant species of sub family valerianaceae a review on its effect on the central nervous system |
| topic | Valerianaceae anxiolytic sedative myorelaxant antidepressant biological activities |
| url | https://www.mdpi.com/2223-7747/10/5/846 |
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