Awareness of Asthma Genetics in Pakistan: A Review with Some Recommendations
About 334 million people worldwide have been affected by asthma and additionally 100 million expected to have asthma by the year 2025. Being the sixth most populous and economically developing country and with the increasing trend of urbanization and due to poor health facilities, lacking the knowle...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Running Line
2018-11-01
|
| Series: | Advancements in Life Sciences |
| Subjects: | |
| Online Access: | http://www.als-journal.com/611-18/ |
| _version_ | 1797728384191561728 |
|---|---|
| author | Muhammad Farooq Sabar Muhammad Akram Farheena Iqbal Awan Muhammad Usman Ghani Mariam Shahid Zafar Iqbal Samra Kousar Muhammad Idrees |
| author_facet | Muhammad Farooq Sabar Muhammad Akram Farheena Iqbal Awan Muhammad Usman Ghani Mariam Shahid Zafar Iqbal Samra Kousar Muhammad Idrees |
| author_sort | Muhammad Farooq Sabar |
| collection | DOAJ |
| description | About 334 million people worldwide have been affected by asthma and additionally 100 million expected to have asthma by the year 2025. Being the sixth most populous and economically developing country and with the increasing trend of urbanization and due to poor health facilities, lacking the knowledge of the causes of the disease, increased pollutant exposures and consanguineous marriages, Pakistani population has greater chances of asthma and allergic diseases. Almost 20% of overall pediatric population of Pakistan is affected by this disease. In the past, only environmental factors were considered responsible for asthma but now it is a well-known fact that genetic factors have major contribution in the development of the disease. Poor knowledge of the possibility of genetics involved in this disease has been very common in both uneducated as well as educated population of this region. There is no doubt today that genetics have a major role in the exhibition of asthma but unlike other Mendelian disorders it cannot easily be identified by a single or a simple set of associated genes, rather small contributions of multiple genes and environmental exposure to asthmatic patients may be found. Our focus in this article is genetic factors of asthma in Pakistan. More than 100 genes associated with asthma have already been reported in different populations worldwide but generally, due to an ignored disease in this region, possible genetic causes, impacts, management and treatment of the disease has rarely been studied in Pakistan. This article was intended to explore some latest developments in asthma genetics, diagnosis, prognosis and management and suggest some recommendations to control this deadly disease. |
| first_indexed | 2024-03-12T11:13:10Z |
| format | Article |
| id | doaj.art-04834feb5e0142eca906024055223210 |
| institution | Directory Open Access Journal |
| issn | 2310-5380 2310-5380 |
| language | English |
| last_indexed | 2024-03-12T11:13:10Z |
| publishDate | 2018-11-01 |
| publisher | The Running Line |
| record_format | Article |
| series | Advancements in Life Sciences |
| spelling | doaj.art-04834feb5e0142eca9060240552232102023-09-02T02:29:12ZengThe Running LineAdvancements in Life Sciences2310-53802310-53802018-11-0161110Awareness of Asthma Genetics in Pakistan: A Review with Some RecommendationsMuhammad Farooq Sabar0Muhammad Akram1Farheena Iqbal Awan2Muhammad Usman Ghani3Mariam Shahid4Zafar Iqbal5Samra Kousar6 Muhammad Idrees7CAMB, University of the Punjab, Lahore, PakistanCAMB, University of the Punjab, Lahore, PakistanCAMB, University of the Punjab, Lahore, PakistanCAMB, University of the Punjab, Lahore, PakistanCEMB, University of the Punjab, Lahore, PakistanKing Saud Bin Abdulaziz University for Health Sciences, KSA, Saudi ArabiaCEMB, University of the Punjab, Lahore, PakistanCAMB, University of the Punjab, Lahore, PakistanAbout 334 million people worldwide have been affected by asthma and additionally 100 million expected to have asthma by the year 2025. Being the sixth most populous and economically developing country and with the increasing trend of urbanization and due to poor health facilities, lacking the knowledge of the causes of the disease, increased pollutant exposures and consanguineous marriages, Pakistani population has greater chances of asthma and allergic diseases. Almost 20% of overall pediatric population of Pakistan is affected by this disease. In the past, only environmental factors were considered responsible for asthma but now it is a well-known fact that genetic factors have major contribution in the development of the disease. Poor knowledge of the possibility of genetics involved in this disease has been very common in both uneducated as well as educated population of this region. There is no doubt today that genetics have a major role in the exhibition of asthma but unlike other Mendelian disorders it cannot easily be identified by a single or a simple set of associated genes, rather small contributions of multiple genes and environmental exposure to asthmatic patients may be found. Our focus in this article is genetic factors of asthma in Pakistan. More than 100 genes associated with asthma have already been reported in different populations worldwide but generally, due to an ignored disease in this region, possible genetic causes, impacts, management and treatment of the disease has rarely been studied in Pakistan. This article was intended to explore some latest developments in asthma genetics, diagnosis, prognosis and management and suggest some recommendations to control this deadly disease.http://www.als-journal.com/611-18/Asthma geneticsAsthma prevalence in PakistanGenetic variants and asthmaAsthma genetic factorsAsthma genetic studies |
| spellingShingle | Muhammad Farooq Sabar Muhammad Akram Farheena Iqbal Awan Muhammad Usman Ghani Mariam Shahid Zafar Iqbal Samra Kousar Muhammad Idrees Awareness of Asthma Genetics in Pakistan: A Review with Some Recommendations Advancements in Life Sciences Asthma genetics Asthma prevalence in Pakistan Genetic variants and asthma Asthma genetic factors Asthma genetic studies |
| title | Awareness of Asthma Genetics in Pakistan: A Review with Some Recommendations |
| title_full | Awareness of Asthma Genetics in Pakistan: A Review with Some Recommendations |
| title_fullStr | Awareness of Asthma Genetics in Pakistan: A Review with Some Recommendations |
| title_full_unstemmed | Awareness of Asthma Genetics in Pakistan: A Review with Some Recommendations |
| title_short | Awareness of Asthma Genetics in Pakistan: A Review with Some Recommendations |
| title_sort | awareness of asthma genetics in pakistan a review with some recommendations |
| topic | Asthma genetics Asthma prevalence in Pakistan Genetic variants and asthma Asthma genetic factors Asthma genetic studies |
| url | http://www.als-journal.com/611-18/ |
| work_keys_str_mv | AT muhammadfarooqsabar awarenessofasthmageneticsinpakistanareviewwithsomerecommendations AT muhammadakram awarenessofasthmageneticsinpakistanareviewwithsomerecommendations AT farheenaiqbalawan awarenessofasthmageneticsinpakistanareviewwithsomerecommendations AT muhammadusmanghani awarenessofasthmageneticsinpakistanareviewwithsomerecommendations AT mariamshahid awarenessofasthmageneticsinpakistanareviewwithsomerecommendations AT zafariqbal awarenessofasthmageneticsinpakistanareviewwithsomerecommendations AT samrakousar awarenessofasthmageneticsinpakistanareviewwithsomerecommendations AT muhammadidrees awarenessofasthmageneticsinpakistanareviewwithsomerecommendations |