Lifestyle intervention reduces risk score for cardiovascular mortality in company employees with pre-diabetes or diabetes mellitus – A secondary analysis of the PreFord randomized controlled trial with 3 years of follow-up
AimTo evaluate the effects of a multimodal intervention (including exercise training, psychosocial interventions, nutrition coaching, smoking cessation program, medical care) on the health and long-term cardiovascular disease (CVD) mortality risk of company employees with pre-diabetes or diabetes me...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1106334/full |
| _version_ | 1797900399798124544 |
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| author | Christian Brinkmann Christian Brinkmann Hannah Hof Detlef-Bernd Gysan Christian Albus Stefanie Millentrup Birna Bjarnason-Wehrens Joachim Latsch Gerd Herold Karl Wegscheider Christian Heming Melchior Seyfarth Melchior Seyfarth Hans-Georg Predel |
| author_facet | Christian Brinkmann Christian Brinkmann Hannah Hof Detlef-Bernd Gysan Christian Albus Stefanie Millentrup Birna Bjarnason-Wehrens Joachim Latsch Gerd Herold Karl Wegscheider Christian Heming Melchior Seyfarth Melchior Seyfarth Hans-Georg Predel |
| author_sort | Christian Brinkmann |
| collection | DOAJ |
| description | AimTo evaluate the effects of a multimodal intervention (including exercise training, psychosocial interventions, nutrition coaching, smoking cessation program, medical care) on the health and long-term cardiovascular disease (CVD) mortality risk of company employees with pre-diabetes or diabetes mellitus (DM) at high CVD risk.MethodsIn the PreFord study, German company employees (n=4196) participated in a free-of-charge CVD mortality risk screening at their workplace. Based on their European Society of Cardiology – Systematic Coronary Risk Evaluation score (ESC-SCORE), they were subdivided into three risk groups. High-risk patients (ESC-SCORE≥5%) were randomly assigned to a 15-week lifestyle intervention or usual care control group. Data from patients with pre-DM/DM were analyzed intention-to-treat (ITT: n=110 versus n=96) and per protocol (PP: n=60 versus n=52).ResultsBody mass index, glycated hemoglobin, total cholesterol, low-density lipoprotein, triglyceride levels as well as systolic and diastolic blood pressure improved through the intervention (ITT, PP: p<0.001). The ESC-SCORE markedly decreased from pre- to post-intervention (ITT, PP: p<0.001). ESC-SCORE changes from baseline differed significantly between the groups, with the intervention group achieving more favorable results in all follow-up visits 6, 12, 24 and 36 months later (at each time point: ITT: p<0.001; PP: p ≤ 0.010).ConclusionThe study demonstrates the feasibility of attracting employees with pre-DM/DM at high CVD mortality risk to participate in a multimodal lifestyle program following a free CVD mortality risk screening at their workplace. The lifestyle intervention used in the PreFord study shows high potential for improving health of company employees with pre-DM/DM in the long term. ISRCTN23536103. |
| first_indexed | 2024-04-10T08:44:18Z |
| format | Article |
| id | doaj.art-04855fdbb99f4360bd16e278fbd0588c |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T08:44:18Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-04855fdbb99f4360bd16e278fbd0588c2023-02-22T09:26:32ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-02-011410.3389/fendo.2023.11063341106334Lifestyle intervention reduces risk score for cardiovascular mortality in company employees with pre-diabetes or diabetes mellitus – A secondary analysis of the PreFord randomized controlled trial with 3 years of follow-upChristian Brinkmann0Christian Brinkmann1Hannah Hof2Detlef-Bernd Gysan3Christian Albus4Stefanie Millentrup5Birna Bjarnason-Wehrens6Joachim Latsch7Gerd Herold8Karl Wegscheider9Christian Heming10Melchior Seyfarth11Melchior Seyfarth12Hans-Georg Predel13Institute of Cardiovascular Research and Sport Medicine, Department of Preventive and Rehabilitative Sport Medicine, German Sport University Cologne, Cologne, GermanyDepartment of Fitness and Health, IST University of Applied Sciences, Düsseldorf, GermanyInstitute of Cardiovascular Research and Sport Medicine, Department of Preventive and Rehabilitative Sport Medicine, German Sport University Cologne, Cologne, GermanyMedical Center for Cardiology, Angiology, Pneumology and Rehabilitation Medicine, Cologne, GermanyDepartment of Psychosomatics and Psychotherapy, University of Cologne, Cologne, GermanyInstitute of Cardiovascular Research and Sport Medicine, Department of Preventive and Rehabilitative Sport Medicine, German Sport University Cologne, Cologne, GermanyInstitute of Cardiovascular Research and Sport Medicine, Department of Preventive and Rehabilitative Sport Medicine, German Sport University Cologne, Cologne, GermanyFresenius University of Applied Sciences, Cologne, GermanyHealth Service of the Ford Motor Company GmbH, Cologne, GermanyInstitute of Medical Biometry and Epidemiology, University of Hamburg-Eppendorf, Hamburg, GermanyInstitute of Cardiovascular Research and Sport Medicine, Department of Preventive and Rehabilitative Sport Medicine, German Sport University Cologne, Cologne, GermanyHELIOS University Hospital Wuppertal, Wuppertal, GermanyWitten/Herdecke University, Witten, GermanyInstitute of Cardiovascular Research and Sport Medicine, Department of Preventive and Rehabilitative Sport Medicine, German Sport University Cologne, Cologne, GermanyAimTo evaluate the effects of a multimodal intervention (including exercise training, psychosocial interventions, nutrition coaching, smoking cessation program, medical care) on the health and long-term cardiovascular disease (CVD) mortality risk of company employees with pre-diabetes or diabetes mellitus (DM) at high CVD risk.MethodsIn the PreFord study, German company employees (n=4196) participated in a free-of-charge CVD mortality risk screening at their workplace. Based on their European Society of Cardiology – Systematic Coronary Risk Evaluation score (ESC-SCORE), they were subdivided into three risk groups. High-risk patients (ESC-SCORE≥5%) were randomly assigned to a 15-week lifestyle intervention or usual care control group. Data from patients with pre-DM/DM were analyzed intention-to-treat (ITT: n=110 versus n=96) and per protocol (PP: n=60 versus n=52).ResultsBody mass index, glycated hemoglobin, total cholesterol, low-density lipoprotein, triglyceride levels as well as systolic and diastolic blood pressure improved through the intervention (ITT, PP: p<0.001). The ESC-SCORE markedly decreased from pre- to post-intervention (ITT, PP: p<0.001). ESC-SCORE changes from baseline differed significantly between the groups, with the intervention group achieving more favorable results in all follow-up visits 6, 12, 24 and 36 months later (at each time point: ITT: p<0.001; PP: p ≤ 0.010).ConclusionThe study demonstrates the feasibility of attracting employees with pre-DM/DM at high CVD mortality risk to participate in a multimodal lifestyle program following a free CVD mortality risk screening at their workplace. The lifestyle intervention used in the PreFord study shows high potential for improving health of company employees with pre-DM/DM in the long term. ISRCTN23536103.https://www.frontiersin.org/articles/10.3389/fendo.2023.1106334/fullexercisenutritioncardiovascular risk assessmentemployeesdiabetes |
| spellingShingle | Christian Brinkmann Christian Brinkmann Hannah Hof Detlef-Bernd Gysan Christian Albus Stefanie Millentrup Birna Bjarnason-Wehrens Joachim Latsch Gerd Herold Karl Wegscheider Christian Heming Melchior Seyfarth Melchior Seyfarth Hans-Georg Predel Lifestyle intervention reduces risk score for cardiovascular mortality in company employees with pre-diabetes or diabetes mellitus – A secondary analysis of the PreFord randomized controlled trial with 3 years of follow-up Frontiers in Endocrinology exercise nutrition cardiovascular risk assessment employees diabetes |
| title | Lifestyle intervention reduces risk score for cardiovascular mortality in company employees with pre-diabetes or diabetes mellitus – A secondary analysis of the PreFord randomized controlled trial with 3 years of follow-up |
| title_full | Lifestyle intervention reduces risk score for cardiovascular mortality in company employees with pre-diabetes or diabetes mellitus – A secondary analysis of the PreFord randomized controlled trial with 3 years of follow-up |
| title_fullStr | Lifestyle intervention reduces risk score for cardiovascular mortality in company employees with pre-diabetes or diabetes mellitus – A secondary analysis of the PreFord randomized controlled trial with 3 years of follow-up |
| title_full_unstemmed | Lifestyle intervention reduces risk score for cardiovascular mortality in company employees with pre-diabetes or diabetes mellitus – A secondary analysis of the PreFord randomized controlled trial with 3 years of follow-up |
| title_short | Lifestyle intervention reduces risk score for cardiovascular mortality in company employees with pre-diabetes or diabetes mellitus – A secondary analysis of the PreFord randomized controlled trial with 3 years of follow-up |
| title_sort | lifestyle intervention reduces risk score for cardiovascular mortality in company employees with pre diabetes or diabetes mellitus a secondary analysis of the preford randomized controlled trial with 3 years of follow up |
| topic | exercise nutrition cardiovascular risk assessment employees diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1106334/full |
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