Current approaches to development of contrast agents for MRI diagnostics

Magnetic resonance imaging (MRI) is primarily used in medical imaging to visualize the structure and function of the body and essential tool for diagnostics of broad range of pathologies. But still in a growing number of cases there are indications to use contrast agent to delineate areas of interes...

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Main Authors: K. N. Sorokina, A. A. Tulupov, T. G. Tolstikova, V. Yu. Ussov
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2011-12-01
Series:Бюллетень сибирской медицины
Subjects:
Online Access:https://bulletin.ssmu.ru/jour/article/view/1506
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author K. N. Sorokina
A. A. Tulupov
T. G. Tolstikova
V. Yu. Ussov
author_facet K. N. Sorokina
A. A. Tulupov
T. G. Tolstikova
V. Yu. Ussov
author_sort K. N. Sorokina
collection DOAJ
description Magnetic resonance imaging (MRI) is primarily used in medical imaging to visualize the structure and function of the body and essential tool for diagnostics of broad range of pathologies. But still in a growing number of cases there are indications to use contrast agent to delineate areas of interest and for more precise diagnosis definition. In a review the properties and clinical applications of most popular paramagnetic contrast agents based on Gd(III), Fe(II) и Mn(II) are discussed. It is also focused on discussion of modern experimental targeted contrast agents (conjugates of antibodies, nanoparticles and dendrimers) and advances of their application for early diagnostics of most common pathologies: cardiovascular, cancer and Alzheimer diseases.
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spelling doaj.art-0485bf6e74394d48b19f03e08dce73692023-03-13T09:58:15ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842011-12-01106798510.20538/1682-0363-2011-6-79-851012Current approaches to development of contrast agents for MRI diagnosticsK. N. Sorokina0A. A. Tulupov1T. G. Tolstikova2V. Yu. Ussov3Институт катализа им. Г.К. Борескова СО РАНИнститут «Международный томографический центр» СО РАНИнститут органической химии им. Н.Н. Ворожцова СО РАНИнститут «Международный томографический центр» СО РАНMagnetic resonance imaging (MRI) is primarily used in medical imaging to visualize the structure and function of the body and essential tool for diagnostics of broad range of pathologies. But still in a growing number of cases there are indications to use contrast agent to delineate areas of interest and for more precise diagnosis definition. In a review the properties and clinical applications of most popular paramagnetic contrast agents based on Gd(III), Fe(II) и Mn(II) are discussed. It is also focused on discussion of modern experimental targeted contrast agents (conjugates of antibodies, nanoparticles and dendrimers) and advances of their application for early diagnostics of most common pathologies: cardiovascular, cancer and Alzheimer diseases.https://bulletin.ssmu.ru/jour/article/view/1506магнитно-резонансная томографияконтрастные агенты для мртэкспериментальные контрастные препараты
spellingShingle K. N. Sorokina
A. A. Tulupov
T. G. Tolstikova
V. Yu. Ussov
Current approaches to development of contrast agents for MRI diagnostics
Бюллетень сибирской медицины
магнитно-резонансная томография
контрастные агенты для мрт
экспериментальные контрастные препараты
title Current approaches to development of contrast agents for MRI diagnostics
title_full Current approaches to development of contrast agents for MRI diagnostics
title_fullStr Current approaches to development of contrast agents for MRI diagnostics
title_full_unstemmed Current approaches to development of contrast agents for MRI diagnostics
title_short Current approaches to development of contrast agents for MRI diagnostics
title_sort current approaches to development of contrast agents for mri diagnostics
topic магнитно-резонансная томография
контрастные агенты для мрт
экспериментальные контрастные препараты
url https://bulletin.ssmu.ru/jour/article/view/1506
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AT aatulupov currentapproachestodevelopmentofcontrastagentsformridiagnostics
AT tgtolstikova currentapproachestodevelopmentofcontrastagentsformridiagnostics
AT vyuussov currentapproachestodevelopmentofcontrastagentsformridiagnostics