Unconjugated Bilirubin Attenuates DSS-Induced Colitis Potentially via Enhancement of Bilirubin Reabsorption

Unconjugated Bilirubin Attenuates DSS-Induced Colitis Potentially via Enhancement of Bilirubin Reabsorption

Studies increasingly show that ulcerative colitis (UC) is a consequence of an imbalance between oxidative stress and antioxidant capacity. Bilirubin exerts an anti-inflammatory effect by scavenging reactive oxygen species (ROS), although the exact mechanism is not completely understood. The aim of t...

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Bibliographic Details
Main Authors: Chong Zhao, Hongli Huang, Qiuhua Pan, Wenqi Huang, Wu Peng, Haoming Xu, Zhiqiang Feng, Yanlei Du, Yuqiang Nie, Yongjian Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
ulcerative colitis
bilirubin
antioxidant
enterohepatic cycling
superoxide (O2·−)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.654808/full

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