Injectable SN-38-embedded Polymeric Microparticles Promote Antitumor Efficacy against Malignant Glioma in an Animal Model
Malignant glioma (MG) is extremely aggressive and highly resistant to chemotherapeutic agents. Using electrospraying, the potent chemotherapeutic agent 7-ethyl-10-hydroxycamptothecia (SN-38) was embedded into 50:50 biodegradable poly[(<span style="font-variant: small-caps;">d,l</s...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/12/5/479 |
| _version_ | 1797567125000290304 |
|---|---|
| author | Yuan-Yun Tseng Tao-Chieh Yang Shu-Mei Chen Shun-Tai Yang Ya-Ling Tang Shih-Jung Liu |
| author_facet | Yuan-Yun Tseng Tao-Chieh Yang Shu-Mei Chen Shun-Tai Yang Ya-Ling Tang Shih-Jung Liu |
| author_sort | Yuan-Yun Tseng |
| collection | DOAJ |
| description | Malignant glioma (MG) is extremely aggressive and highly resistant to chemotherapeutic agents. Using electrospraying, the potent chemotherapeutic agent 7-ethyl-10-hydroxycamptothecia (SN-38) was embedded into 50:50 biodegradable poly[(<span style="font-variant: small-caps;">d,l</span>)-lactide-<i>co</i>-glycolide] (PLGA) microparticles (SMPs). The SMPs were stereotactically injected into the brain parenchyma of healthy rats and intratumorally injected into F98 glioma-bearing rats for estimating the pharmacodynamics and therapeutic efficacy. SN-38 was rapidly released after injection and its local (brain tissue) concentration remained much higher than that in the blood for more than 8 weeks. Glioma-bearing rats were divided into three groups—group A (<i>n</i> = 13; stereotactically injected pure PLGA microparticles), group B (<i>n</i> = 12; stereotactically injected Gliadel wafer and oral temozolomide), and group C (<i>n</i> = 13; stereotactic and intratumoral introduction of SMPs). The SMPs exhibited significant therapeutic efficacy, with prolonged survival, retarded tumor growth, and attenuated malignancy. The experimental results demonstrated that SMPs provide an effective and potential strategy for the treatment of MG. |
| first_indexed | 2024-03-10T19:37:18Z |
| format | Article |
| id | doaj.art-0486fc2f4eed43b989687b5ffa62edef |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T19:37:18Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-0486fc2f4eed43b989687b5ffa62edef2023-11-20T01:33:31ZengMDPI AGPharmaceutics1999-49232020-05-0112547910.3390/pharmaceutics12050479Injectable SN-38-embedded Polymeric Microparticles Promote Antitumor Efficacy against Malignant Glioma in an Animal ModelYuan-Yun Tseng0Tao-Chieh Yang1Shu-Mei Chen2Shun-Tai Yang3Ya-Ling Tang4Shih-Jung Liu5Division of Neurosurgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, Taipei 11031, TaiwanDepartment of Neurosurgery, Chung Shan Medical University Hospital, Taichung 40201, TaiwanDepartment of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, TaiwanDivision of Neurosurgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, Taipei 11031, TaiwanDepartment of Mechanical Engineering, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Mechanical Engineering, Chang Gung University, Taoyuan 33302, TaiwanMalignant glioma (MG) is extremely aggressive and highly resistant to chemotherapeutic agents. Using electrospraying, the potent chemotherapeutic agent 7-ethyl-10-hydroxycamptothecia (SN-38) was embedded into 50:50 biodegradable poly[(<span style="font-variant: small-caps;">d,l</span>)-lactide-<i>co</i>-glycolide] (PLGA) microparticles (SMPs). The SMPs were stereotactically injected into the brain parenchyma of healthy rats and intratumorally injected into F98 glioma-bearing rats for estimating the pharmacodynamics and therapeutic efficacy. SN-38 was rapidly released after injection and its local (brain tissue) concentration remained much higher than that in the blood for more than 8 weeks. Glioma-bearing rats were divided into three groups—group A (<i>n</i> = 13; stereotactically injected pure PLGA microparticles), group B (<i>n</i> = 12; stereotactically injected Gliadel wafer and oral temozolomide), and group C (<i>n</i> = 13; stereotactic and intratumoral introduction of SMPs). The SMPs exhibited significant therapeutic efficacy, with prolonged survival, retarded tumor growth, and attenuated malignancy. The experimental results demonstrated that SMPs provide an effective and potential strategy for the treatment of MG.https://www.mdpi.com/1999-4923/12/5/479malignant glioma (MG)7-ethyl-10-hydroxycamptothecia (SN-38)irinotecan (CPT-11)poly(lactide-<i>co</i>-glycolide) (PLGA)intratumoral drug delivery |
| spellingShingle | Yuan-Yun Tseng Tao-Chieh Yang Shu-Mei Chen Shun-Tai Yang Ya-Ling Tang Shih-Jung Liu Injectable SN-38-embedded Polymeric Microparticles Promote Antitumor Efficacy against Malignant Glioma in an Animal Model Pharmaceutics malignant glioma (MG) 7-ethyl-10-hydroxycamptothecia (SN-38) irinotecan (CPT-11) poly(lactide-<i>co</i>-glycolide) (PLGA) intratumoral drug delivery |
| title | Injectable SN-38-embedded Polymeric Microparticles Promote Antitumor Efficacy against Malignant Glioma in an Animal Model |
| title_full | Injectable SN-38-embedded Polymeric Microparticles Promote Antitumor Efficacy against Malignant Glioma in an Animal Model |
| title_fullStr | Injectable SN-38-embedded Polymeric Microparticles Promote Antitumor Efficacy against Malignant Glioma in an Animal Model |
| title_full_unstemmed | Injectable SN-38-embedded Polymeric Microparticles Promote Antitumor Efficacy against Malignant Glioma in an Animal Model |
| title_short | Injectable SN-38-embedded Polymeric Microparticles Promote Antitumor Efficacy against Malignant Glioma in an Animal Model |
| title_sort | injectable sn 38 embedded polymeric microparticles promote antitumor efficacy against malignant glioma in an animal model |
| topic | malignant glioma (MG) 7-ethyl-10-hydroxycamptothecia (SN-38) irinotecan (CPT-11) poly(lactide-<i>co</i>-glycolide) (PLGA) intratumoral drug delivery |
| url | https://www.mdpi.com/1999-4923/12/5/479 |
| work_keys_str_mv | AT yuanyuntseng injectablesn38embeddedpolymericmicroparticlespromoteantitumorefficacyagainstmalignantgliomainananimalmodel AT taochiehyang injectablesn38embeddedpolymericmicroparticlespromoteantitumorefficacyagainstmalignantgliomainananimalmodel AT shumeichen injectablesn38embeddedpolymericmicroparticlespromoteantitumorefficacyagainstmalignantgliomainananimalmodel AT shuntaiyang injectablesn38embeddedpolymericmicroparticlespromoteantitumorefficacyagainstmalignantgliomainananimalmodel AT yalingtang injectablesn38embeddedpolymericmicroparticlespromoteantitumorefficacyagainstmalignantgliomainananimalmodel AT shihjungliu injectablesn38embeddedpolymericmicroparticlespromoteantitumorefficacyagainstmalignantgliomainananimalmodel |