Premature coronary heart disease complicated with hypertension in hospitalized patients: Incidence, risk factors, cardiovascular-related comorbidities and prognosis, 2008–2018
Background: The clinical characteristics and risk factors of all-cause mortality in young hospitalized patients with comorbid coronary heart disease and hypertension (CAD + HT) are not well-characterized. Method: A total of 2288 hospitalized CAD patients (age<45 years) with or without hypertensio...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772487524000187 |
| _version_ | 1797267573764521984 |
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| author | Yanjie Li Chi Wang Zekun Feng Lu Tian Siyu Yao Miao Wang Maoxiang Zhao Lihua Lan Hao Xue |
| author_facet | Yanjie Li Chi Wang Zekun Feng Lu Tian Siyu Yao Miao Wang Maoxiang Zhao Lihua Lan Hao Xue |
| author_sort | Yanjie Li |
| collection | DOAJ |
| description | Background: The clinical characteristics and risk factors of all-cause mortality in young hospitalized patients with comorbid coronary heart disease and hypertension (CAD + HT) are not well-characterized. Method: A total of 2288 hospitalized CAD patients (age<45 years) with or without hypertension in the Chinese PLA General Hospital from August 5, 2008 to June 22, 2018 were conducted. The risk factors of all-cause mortality were estimated in young CAD + HT patients by COX models. Results: The overall prevalence of hypertension in young CAD patients was 50.83% (n = 1163). CAD + HT patients had older age, higher heart rate, BMI, uric acid, triglyceride and lower level of eGFR and HDL-C than CAD patients (P < 0.05). The proportion of cardiovascular-related comorbidities (including obesity, diabetes mellitus, hyperuricemia and chronic kidney disease [CKD]) in the CAD + HT group was significantly higher than that in CAD group (P < 0.0001). The risk of all-cause mortality was higher in CAD + HT patients, although after adjusting for all covariates, there was no significant difference between the two groups. Furthermore, CKD (HR, 3.662; 95% CI, 1.545–8.682) and heart failure (HF) (HR, 3.136; 95%CI, 1.276–7.703) were associated with an increased risk of all-cause mortality and RAASi (HR, 0.378; 95%CI, 0.174–0.819) had a beneficial impact in CAD + HT patients. Conclusions: Hypertension was highly prevalent in young CAD patients. Young CAD + HT patients had more cardiovascular metabolic risk factors, more cardiovascular-related comorbidities and higher risk of all-cause mortality. CKD and HF were the risk factors, while RAASi was a protective factor, of all-cause mortality in CAD + HT patients. |
| first_indexed | 2024-04-25T01:18:44Z |
| format | Article |
| id | doaj.art-048762d8b4db47ae8e69bb04e18e425f |
| institution | Directory Open Access Journal |
| issn | 2772-4875 |
| language | English |
| last_indexed | 2024-04-25T01:18:44Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| spelling | doaj.art-048762d8b4db47ae8e69bb04e18e425f2024-03-09T09:29:50ZengElsevierInternational Journal of Cardiology. Cardiovascular Risk and Prevention2772-48752024-06-0121200253Premature coronary heart disease complicated with hypertension in hospitalized patients: Incidence, risk factors, cardiovascular-related comorbidities and prognosis, 2008–2018Yanjie Li0Chi Wang1Zekun Feng2Lu Tian3Siyu Yao4Miao Wang5Maoxiang Zhao6Lihua Lan7Hao Xue8School of Medicine, Nankai University, Tianjin, 300071, China; Department of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, 100048, ChinaDepartment of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, 100048, ChinaDepartment of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, 100048, ChinaSchool of Medicine, Nankai University, Tianjin, 300071, China; Department of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, 100048, ChinaDepartment of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, 100048, ChinaSchool of Medicine, Nankai University, Tianjin, 300071, China; Department of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, 100048, ChinaDepartment of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, 100048, ChinaSchool of Medicine, Nankai University, Tianjin, 300071, China; Department of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, 100048, ChinaDepartment of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, 100048, China; Corresponding author. Department of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, 6 Fucheng RD., Beijing, 100048, China.Background: The clinical characteristics and risk factors of all-cause mortality in young hospitalized patients with comorbid coronary heart disease and hypertension (CAD + HT) are not well-characterized. Method: A total of 2288 hospitalized CAD patients (age<45 years) with or without hypertension in the Chinese PLA General Hospital from August 5, 2008 to June 22, 2018 were conducted. The risk factors of all-cause mortality were estimated in young CAD + HT patients by COX models. Results: The overall prevalence of hypertension in young CAD patients was 50.83% (n = 1163). CAD + HT patients had older age, higher heart rate, BMI, uric acid, triglyceride and lower level of eGFR and HDL-C than CAD patients (P < 0.05). The proportion of cardiovascular-related comorbidities (including obesity, diabetes mellitus, hyperuricemia and chronic kidney disease [CKD]) in the CAD + HT group was significantly higher than that in CAD group (P < 0.0001). The risk of all-cause mortality was higher in CAD + HT patients, although after adjusting for all covariates, there was no significant difference between the two groups. Furthermore, CKD (HR, 3.662; 95% CI, 1.545–8.682) and heart failure (HF) (HR, 3.136; 95%CI, 1.276–7.703) were associated with an increased risk of all-cause mortality and RAASi (HR, 0.378; 95%CI, 0.174–0.819) had a beneficial impact in CAD + HT patients. Conclusions: Hypertension was highly prevalent in young CAD patients. Young CAD + HT patients had more cardiovascular metabolic risk factors, more cardiovascular-related comorbidities and higher risk of all-cause mortality. CKD and HF were the risk factors, while RAASi was a protective factor, of all-cause mortality in CAD + HT patients.http://www.sciencedirect.com/science/article/pii/S2772487524000187Coronary heart diseaseHypertensionComorbidityAll-cause mortality |
| spellingShingle | Yanjie Li Chi Wang Zekun Feng Lu Tian Siyu Yao Miao Wang Maoxiang Zhao Lihua Lan Hao Xue Premature coronary heart disease complicated with hypertension in hospitalized patients: Incidence, risk factors, cardiovascular-related comorbidities and prognosis, 2008–2018 International Journal of Cardiology. Cardiovascular Risk and Prevention Coronary heart disease Hypertension Comorbidity All-cause mortality |
| title | Premature coronary heart disease complicated with hypertension in hospitalized patients: Incidence, risk factors, cardiovascular-related comorbidities and prognosis, 2008–2018 |
| title_full | Premature coronary heart disease complicated with hypertension in hospitalized patients: Incidence, risk factors, cardiovascular-related comorbidities and prognosis, 2008–2018 |
| title_fullStr | Premature coronary heart disease complicated with hypertension in hospitalized patients: Incidence, risk factors, cardiovascular-related comorbidities and prognosis, 2008–2018 |
| title_full_unstemmed | Premature coronary heart disease complicated with hypertension in hospitalized patients: Incidence, risk factors, cardiovascular-related comorbidities and prognosis, 2008–2018 |
| title_short | Premature coronary heart disease complicated with hypertension in hospitalized patients: Incidence, risk factors, cardiovascular-related comorbidities and prognosis, 2008–2018 |
| title_sort | premature coronary heart disease complicated with hypertension in hospitalized patients incidence risk factors cardiovascular related comorbidities and prognosis 2008 2018 |
| topic | Coronary heart disease Hypertension Comorbidity All-cause mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2772487524000187 |
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