Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications
Xiao-Dong Zhang,1 Jiang Yang,2 Sha-Sha Song,1 Wei Long,1 Jie Chen,1 Xiu Shen,1 Hao Wang,1 Yuan-Ming Sun,1 Pei-Xun Liu,1 Saijun Fan11Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, Pe...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2014-04-01
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| Series: | International Journal of Nanomedicine |
| Online Access: | http://www.dovepress.com/passing-through-the-renal-clearance-barrier-toward-ultrasmall-sizes-wi-a16558 |
| _version_ | 1818367134753882112 |
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| author | Zhang XD Yang J Song SS Long W Chen J Shen X Wang H Sun YM Liu PX Fan S |
| author_facet | Zhang XD Yang J Song SS Long W Chen J Shen X Wang H Sun YM Liu PX Fan S |
| author_sort | Zhang XD |
| collection | DOAJ |
| description | Xiao-Dong Zhang,1 Jiang Yang,2 Sha-Sha Song,1 Wei Long,1 Jie Chen,1 Xiu Shen,1 Hao Wang,1 Yuan-Ming Sun,1 Pei-Xun Liu,1 Saijun Fan11Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People's Republic of China; 2Department of Biological Systems Engineering, University of Wisconsin-Madison, Madison, WI, USAAbstract: The use of nanoparticles holds promise for medical applications, such as X-ray imaging, photothermal therapy and radiotherapy. However, the in vivo toxicity of inorganic nanoparticles raises some concern regarding undesirable side effects which prevent their further medical application. Ultrasmall sub-5.5 nm particles can pass through the barrier for renal clearance, minimizing their toxicity. In this letter we address some recent interesting work regarding in vivo toxicity and renal clearance, and discuss the possible strategy of utilizing ultrasmall nanomaterials. We propose that small hydrodynamic sized nanoclusters can achieve both nontoxic and therapeutic clinical features.Keywords: in vivo clearance, gold nanoparticles, small size |
| first_indexed | 2024-12-13T22:47:14Z |
| format | Article |
| id | doaj.art-048826a0a260448ea1cb7b46c6996da9 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-13T22:47:14Z |
| publishDate | 2014-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-048826a0a260448ea1cb7b46c6996da92022-12-21T23:28:42ZengDove Medical PressInternational Journal of Nanomedicine1178-20132014-04-012014Issue 12069207216558Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applicationsZhang XDYang JSong SSLong WChen JShen XWang HSun YMLiu PXFan SXiao-Dong Zhang,1 Jiang Yang,2 Sha-Sha Song,1 Wei Long,1 Jie Chen,1 Xiu Shen,1 Hao Wang,1 Yuan-Ming Sun,1 Pei-Xun Liu,1 Saijun Fan11Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People's Republic of China; 2Department of Biological Systems Engineering, University of Wisconsin-Madison, Madison, WI, USAAbstract: The use of nanoparticles holds promise for medical applications, such as X-ray imaging, photothermal therapy and radiotherapy. However, the in vivo toxicity of inorganic nanoparticles raises some concern regarding undesirable side effects which prevent their further medical application. Ultrasmall sub-5.5 nm particles can pass through the barrier for renal clearance, minimizing their toxicity. In this letter we address some recent interesting work regarding in vivo toxicity and renal clearance, and discuss the possible strategy of utilizing ultrasmall nanomaterials. We propose that small hydrodynamic sized nanoclusters can achieve both nontoxic and therapeutic clinical features.Keywords: in vivo clearance, gold nanoparticles, small sizehttp://www.dovepress.com/passing-through-the-renal-clearance-barrier-toward-ultrasmall-sizes-wi-a16558 |
| spellingShingle | Zhang XD Yang J Song SS Long W Chen J Shen X Wang H Sun YM Liu PX Fan S Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications International Journal of Nanomedicine |
| title | Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications |
| title_full | Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications |
| title_fullStr | Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications |
| title_full_unstemmed | Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications |
| title_short | Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications |
| title_sort | passing through the renal clearance barrier toward ultrasmall sizes with stable ligands for potential clinical applications |
| url | http://www.dovepress.com/passing-through-the-renal-clearance-barrier-toward-ultrasmall-sizes-wi-a16558 |
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