A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation

Post-transplant lymphoproliferative diseases (PTLD) are potentially fatal complications after cardiac transplantation. Most cases are Epstein–Barr virus (EBV)-related B-cell tumors, and reduction of immunosuppression treatment as well as the use of rituximab in combination with other chemotherapy ar...

Full description

Bibliographic Details
Main Authors: Makiko Nakamura, Teruhiko Imamura, Kohji Takagi, Masakazu Hori, Shinichi Tanaka, Joji Imura, Koichiro Kinugawa
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
Online Access:https://www.mdpi.com/2308-3425/9/2/38
_version_ 1797479174306267136
author Makiko Nakamura
Teruhiko Imamura
Kohji Takagi
Masakazu Hori
Shinichi Tanaka
Joji Imura
Koichiro Kinugawa
author_facet Makiko Nakamura
Teruhiko Imamura
Kohji Takagi
Masakazu Hori
Shinichi Tanaka
Joji Imura
Koichiro Kinugawa
author_sort Makiko Nakamura
collection DOAJ
description Post-transplant lymphoproliferative diseases (PTLD) are potentially fatal complications after cardiac transplantation. Most cases are Epstein–Barr virus (EBV)-related B-cell tumors, and reduction of immunosuppression treatment as well as the use of rituximab in combination with other chemotherapy are effective. However, patients with T/NK-cell PTLD post-cardiac transplantation are rarely reported. We had a patient with a fever that lasted for three weeks, with lung infiltrations and hepatosplenomegaly, who had EBV-associated hemophagocytosis 7 years after heart transplantation and was eventually diagnosed with T/NK-cell PTLD by autopsy. Although rare diseases, regular monitoring of EBV-DNA levels might be crucial for early diagnosis and treatment of PTLD.
first_indexed 2024-03-09T21:41:45Z
format Article
id doaj.art-048846b096a04a0fb352bb3dbe262aec
institution Directory Open Access Journal
issn 2308-3425
language English
last_indexed 2024-03-09T21:41:45Z
publishDate 2022-01-01
publisher MDPI AG
record_format Article
series Journal of Cardiovascular Development and Disease
spelling doaj.art-048846b096a04a0fb352bb3dbe262aec2023-11-23T20:28:12ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252022-01-01923810.3390/jcdd9020038A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart TransplantationMakiko Nakamura0Teruhiko Imamura1Kohji Takagi2Masakazu Hori3Shinichi Tanaka4Joji Imura5Koichiro Kinugawa6The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanThe Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanThe Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanThe Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanPost-transplant lymphoproliferative diseases (PTLD) are potentially fatal complications after cardiac transplantation. Most cases are Epstein–Barr virus (EBV)-related B-cell tumors, and reduction of immunosuppression treatment as well as the use of rituximab in combination with other chemotherapy are effective. However, patients with T/NK-cell PTLD post-cardiac transplantation are rarely reported. We had a patient with a fever that lasted for three weeks, with lung infiltrations and hepatosplenomegaly, who had EBV-associated hemophagocytosis 7 years after heart transplantation and was eventually diagnosed with T/NK-cell PTLD by autopsy. Although rare diseases, regular monitoring of EBV-DNA levels might be crucial for early diagnosis and treatment of PTLD.https://www.mdpi.com/2308-3425/9/2/38Epstein–Barr viruscardiomyopathyimmunosupressanthemophagocytosis
spellingShingle Makiko Nakamura
Teruhiko Imamura
Kohji Takagi
Masakazu Hori
Shinichi Tanaka
Joji Imura
Koichiro Kinugawa
A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation
Journal of Cardiovascular Development and Disease
Epstein–Barr virus
cardiomyopathy
immunosupressant
hemophagocytosis
title A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation
title_full A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation
title_fullStr A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation
title_full_unstemmed A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation
title_short A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation
title_sort case of t nk cell post transplantation lymphoproliferative disease 7 years after heart transplantation
topic Epstein–Barr virus
cardiomyopathy
immunosupressant
hemophagocytosis
url https://www.mdpi.com/2308-3425/9/2/38
work_keys_str_mv AT makikonakamura acaseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT teruhikoimamura acaseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT kohjitakagi acaseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT masakazuhori acaseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT shinichitanaka acaseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT jojiimura acaseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT koichirokinugawa acaseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT makikonakamura caseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT teruhikoimamura caseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT kohjitakagi caseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT masakazuhori caseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT shinichitanaka caseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT jojiimura caseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation
AT koichirokinugawa caseoftnkcellposttransplantationlymphoproliferativedisease7yearsafterhearttransplantation