A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation
Post-transplant lymphoproliferative diseases (PTLD) are potentially fatal complications after cardiac transplantation. Most cases are Epstein–Barr virus (EBV)-related B-cell tumors, and reduction of immunosuppression treatment as well as the use of rituximab in combination with other chemotherapy ar...
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MDPI AG
2022-01-01
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Series: | Journal of Cardiovascular Development and Disease |
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Online Access: | https://www.mdpi.com/2308-3425/9/2/38 |
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author | Makiko Nakamura Teruhiko Imamura Kohji Takagi Masakazu Hori Shinichi Tanaka Joji Imura Koichiro Kinugawa |
author_facet | Makiko Nakamura Teruhiko Imamura Kohji Takagi Masakazu Hori Shinichi Tanaka Joji Imura Koichiro Kinugawa |
author_sort | Makiko Nakamura |
collection | DOAJ |
description | Post-transplant lymphoproliferative diseases (PTLD) are potentially fatal complications after cardiac transplantation. Most cases are Epstein–Barr virus (EBV)-related B-cell tumors, and reduction of immunosuppression treatment as well as the use of rituximab in combination with other chemotherapy are effective. However, patients with T/NK-cell PTLD post-cardiac transplantation are rarely reported. We had a patient with a fever that lasted for three weeks, with lung infiltrations and hepatosplenomegaly, who had EBV-associated hemophagocytosis 7 years after heart transplantation and was eventually diagnosed with T/NK-cell PTLD by autopsy. Although rare diseases, regular monitoring of EBV-DNA levels might be crucial for early diagnosis and treatment of PTLD. |
first_indexed | 2024-03-09T21:41:45Z |
format | Article |
id | doaj.art-048846b096a04a0fb352bb3dbe262aec |
institution | Directory Open Access Journal |
issn | 2308-3425 |
language | English |
last_indexed | 2024-03-09T21:41:45Z |
publishDate | 2022-01-01 |
publisher | MDPI AG |
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series | Journal of Cardiovascular Development and Disease |
spelling | doaj.art-048846b096a04a0fb352bb3dbe262aec2023-11-23T20:28:12ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252022-01-01923810.3390/jcdd9020038A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart TransplantationMakiko Nakamura0Teruhiko Imamura1Kohji Takagi2Masakazu Hori3Shinichi Tanaka4Joji Imura5Koichiro Kinugawa6The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanThe Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanThe Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanThe Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanPost-transplant lymphoproliferative diseases (PTLD) are potentially fatal complications after cardiac transplantation. Most cases are Epstein–Barr virus (EBV)-related B-cell tumors, and reduction of immunosuppression treatment as well as the use of rituximab in combination with other chemotherapy are effective. However, patients with T/NK-cell PTLD post-cardiac transplantation are rarely reported. We had a patient with a fever that lasted for three weeks, with lung infiltrations and hepatosplenomegaly, who had EBV-associated hemophagocytosis 7 years after heart transplantation and was eventually diagnosed with T/NK-cell PTLD by autopsy. Although rare diseases, regular monitoring of EBV-DNA levels might be crucial for early diagnosis and treatment of PTLD.https://www.mdpi.com/2308-3425/9/2/38Epstein–Barr viruscardiomyopathyimmunosupressanthemophagocytosis |
spellingShingle | Makiko Nakamura Teruhiko Imamura Kohji Takagi Masakazu Hori Shinichi Tanaka Joji Imura Koichiro Kinugawa A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation Journal of Cardiovascular Development and Disease Epstein–Barr virus cardiomyopathy immunosupressant hemophagocytosis |
title | A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation |
title_full | A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation |
title_fullStr | A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation |
title_full_unstemmed | A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation |
title_short | A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation |
title_sort | case of t nk cell post transplantation lymphoproliferative disease 7 years after heart transplantation |
topic | Epstein–Barr virus cardiomyopathy immunosupressant hemophagocytosis |
url | https://www.mdpi.com/2308-3425/9/2/38 |
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