Increased modifiable cardiovascular risk factors in patients with Takayasu arteritis: a multicenter cross-sectional study
Abstract Background Modifiable cardiovascular risk factors (MCRFs), such as those related to aerobic capacity, muscle strength, physical activity, and body composition, have been poorly studied in Takayasu arteritis (TAK). Therefore, the aim of the study was to investigate MCRFs and their relationsh...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-01-01
|
| Series: | Advances in Rheumatology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42358-020-00157-1 |
| _version_ | 1818953203950026752 |
|---|---|
| author | Alexandre Moura dos Santos Rafael Giovani Misse Isabela Bruna Pires Borges Bruno Gualano Alexandre Wagner Silva de Souza Liliam Takayama Rosa Maria R. Pereira Samuel Katsuyuki Shinjo |
| author_facet | Alexandre Moura dos Santos Rafael Giovani Misse Isabela Bruna Pires Borges Bruno Gualano Alexandre Wagner Silva de Souza Liliam Takayama Rosa Maria R. Pereira Samuel Katsuyuki Shinjo |
| author_sort | Alexandre Moura dos Santos |
| collection | DOAJ |
| description | Abstract Background Modifiable cardiovascular risk factors (MCRFs), such as those related to aerobic capacity, muscle strength, physical activity, and body composition, have been poorly studied in Takayasu arteritis (TAK). Therefore, the aim of the study was to investigate MCRFs and their relationships with disease status and comorbidities among patients with TAK. Methods A multicenter cross-sectional study was conducted between 2019 and 2020, in which 20 adult women with TAK were compared with 16 healthy controls matched by gender, age, and body mass index. The following parameters were analyzed: aerobic capacity by cardiopulmonary test; muscle function by timed-stands test, timed up-and-go test, and handgrip test; muscle strength by one-repetition maximum test and handgrip test; body composition by densitometry; physical activity and metabolic equivalent by IPAQ, quality of life by HAQ and SF-36; disease activity by ITAS2010 and NIH score; and presence of comorbidities. Results Patients with TAK had a mean age of 41.5 (38.0–46.3) years, disease duration of 16.0 (9.5–20.0) years, and a mean BMI of 27.7±4.5 kg/m2. Three out of the 20 patients with TAK had active disease. Regarding comorbidities, 16 patients had systemic arterial hypertension, 11 had dyslipidemia, and two had type 2 diabetes mellitus, while the control group had no comorbidities. TAK had a significant reduction in aerobic capacity (absolute and relative VO2 peak), muscle strength in the lower limbs, increased visceral adipose tissue, waist-to-hip ratio, reduced walking capacity, decreased weekly metabolic equivalent, and quality of life (P< 0.05) as compared to controls. However, there were no correlations between these MCRFs parameters and disease activity. Conclusions TAK show impairment in MCRFs; therefore, strategies able to improve MCRF should be considered in this disease. |
| first_indexed | 2024-12-20T10:02:33Z |
| format | Article |
| id | doaj.art-04892b2f808d49708d83929099bcd409 |
| institution | Directory Open Access Journal |
| issn | 2523-3106 |
| language | English |
| last_indexed | 2024-12-20T10:02:33Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj.art-04892b2f808d49708d83929099bcd4092022-12-21T19:44:19ZengBMCAdvances in Rheumatology2523-31062021-01-016111910.1186/s42358-020-00157-1Increased modifiable cardiovascular risk factors in patients with Takayasu arteritis: a multicenter cross-sectional studyAlexandre Moura dos Santos0Rafael Giovani Misse1Isabela Bruna Pires Borges2Bruno Gualano3Alexandre Wagner Silva de Souza4Liliam Takayama5Rosa Maria R. Pereira6Samuel Katsuyuki Shinjo7Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao PauloDivision of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao PauloDivision of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao PauloDivision of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao PauloDivision of Rheumatology, Universidade Federal de São Paulo (UNIFESP)Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao PauloDivision of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao PauloDivision of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao PauloAbstract Background Modifiable cardiovascular risk factors (MCRFs), such as those related to aerobic capacity, muscle strength, physical activity, and body composition, have been poorly studied in Takayasu arteritis (TAK). Therefore, the aim of the study was to investigate MCRFs and their relationships with disease status and comorbidities among patients with TAK. Methods A multicenter cross-sectional study was conducted between 2019 and 2020, in which 20 adult women with TAK were compared with 16 healthy controls matched by gender, age, and body mass index. The following parameters were analyzed: aerobic capacity by cardiopulmonary test; muscle function by timed-stands test, timed up-and-go test, and handgrip test; muscle strength by one-repetition maximum test and handgrip test; body composition by densitometry; physical activity and metabolic equivalent by IPAQ, quality of life by HAQ and SF-36; disease activity by ITAS2010 and NIH score; and presence of comorbidities. Results Patients with TAK had a mean age of 41.5 (38.0–46.3) years, disease duration of 16.0 (9.5–20.0) years, and a mean BMI of 27.7±4.5 kg/m2. Three out of the 20 patients with TAK had active disease. Regarding comorbidities, 16 patients had systemic arterial hypertension, 11 had dyslipidemia, and two had type 2 diabetes mellitus, while the control group had no comorbidities. TAK had a significant reduction in aerobic capacity (absolute and relative VO2 peak), muscle strength in the lower limbs, increased visceral adipose tissue, waist-to-hip ratio, reduced walking capacity, decreased weekly metabolic equivalent, and quality of life (P< 0.05) as compared to controls. However, there were no correlations between these MCRFs parameters and disease activity. Conclusions TAK show impairment in MCRFs; therefore, strategies able to improve MCRF should be considered in this disease.https://doi.org/10.1186/s42358-020-00157-1Aerobic capacityCardiovascular diseasesMuscle strengthVasculitis |
| spellingShingle | Alexandre Moura dos Santos Rafael Giovani Misse Isabela Bruna Pires Borges Bruno Gualano Alexandre Wagner Silva de Souza Liliam Takayama Rosa Maria R. Pereira Samuel Katsuyuki Shinjo Increased modifiable cardiovascular risk factors in patients with Takayasu arteritis: a multicenter cross-sectional study Advances in Rheumatology Aerobic capacity Cardiovascular diseases Muscle strength Vasculitis |
| title | Increased modifiable cardiovascular risk factors in patients with Takayasu arteritis: a multicenter cross-sectional study |
| title_full | Increased modifiable cardiovascular risk factors in patients with Takayasu arteritis: a multicenter cross-sectional study |
| title_fullStr | Increased modifiable cardiovascular risk factors in patients with Takayasu arteritis: a multicenter cross-sectional study |
| title_full_unstemmed | Increased modifiable cardiovascular risk factors in patients with Takayasu arteritis: a multicenter cross-sectional study |
| title_short | Increased modifiable cardiovascular risk factors in patients with Takayasu arteritis: a multicenter cross-sectional study |
| title_sort | increased modifiable cardiovascular risk factors in patients with takayasu arteritis a multicenter cross sectional study |
| topic | Aerobic capacity Cardiovascular diseases Muscle strength Vasculitis |
| url | https://doi.org/10.1186/s42358-020-00157-1 |
| work_keys_str_mv | AT alexandremouradossantos increasedmodifiablecardiovascularriskfactorsinpatientswithtakayasuarteritisamulticentercrosssectionalstudy AT rafaelgiovanimisse increasedmodifiablecardiovascularriskfactorsinpatientswithtakayasuarteritisamulticentercrosssectionalstudy AT isabelabrunapiresborges increasedmodifiablecardiovascularriskfactorsinpatientswithtakayasuarteritisamulticentercrosssectionalstudy AT brunogualano increasedmodifiablecardiovascularriskfactorsinpatientswithtakayasuarteritisamulticentercrosssectionalstudy AT alexandrewagnersilvadesouza increasedmodifiablecardiovascularriskfactorsinpatientswithtakayasuarteritisamulticentercrosssectionalstudy AT liliamtakayama increasedmodifiablecardiovascularriskfactorsinpatientswithtakayasuarteritisamulticentercrosssectionalstudy AT rosamariarpereira increasedmodifiablecardiovascularriskfactorsinpatientswithtakayasuarteritisamulticentercrosssectionalstudy AT samuelkatsuyukishinjo increasedmodifiablecardiovascularriskfactorsinpatientswithtakayasuarteritisamulticentercrosssectionalstudy |