Inflammatory bowel disease and the risk of intracerebral hemorrhage: A Mendelian randomization study and meta‐analysis
Abstract Background The link between inflammatory bowel disease (IBD) and intracerebral hemorrhage (ICH) is still unclear. Aims We conducted a Mendelian randomization research and meta‐analysis to explore the impact of IBD and its subtypes (Crohn's disease [CD], ulcerative colitis [UC]) on the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.1048 |
| _version_ | 1797641934203781120 |
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| author | Yanju Song Xuelun Zou Yi Zeng Le Zhang Xinfa Mao |
| author_facet | Yanju Song Xuelun Zou Yi Zeng Le Zhang Xinfa Mao |
| author_sort | Yanju Song |
| collection | DOAJ |
| description | Abstract Background The link between inflammatory bowel disease (IBD) and intracerebral hemorrhage (ICH) is still unclear. Aims We conducted a Mendelian randomization research and meta‐analysis to explore the impact of IBD and its subtypes (Crohn's disease [CD], ulcerative colitis [UC]) on the risk of ICH. Methods Two large genome‐wide association analysis studies of International Inflammatory Bowel Disease Genetics Consortium (IIBDGC) and International Stroke Genetics Consortium as exposure (IBD, UC, and CD) and outcome (ICH) in the initial stage. IBD, CD, UC GWAS data from the FinnGen consortium were adopted for the replication phase, and ultimately, the results of the initial stage and replication phase data were combined in a meta‐analysis to evaluate the causal association between IBD and its subtypes and the risk of ICH. Results In the initial stage, we found that in the IVW (odds ratio [OR] = 0.83, 95% confidence interval [CI]: 0.71–0.96, p = .01), MR‐PRESSO (OR = 0.85, 95% CI: 0.75–0.97, p = .02) and MR.RAPS (OR = 0.86, 95% CI: 0.76–0.98, p = .02) method showed that UC is associated with the risk of ICH. The causal relationship between IBD, CD, and the risk of ICH cannot be found by the IVW method. IBD and its subtypes UC, CD, and risk of ICH cannot find the presence of heterogeneity and pleiotropy. In replication stage, IBD (OR = 0.74, 95% CI: 0.59–0.94, p = .0135) related to ICH, while the IVW approach did not establish a causal link in UC and CD. The meta‐analysis still indicated that UC (OR = 0.83, 95% CI: 0.72–0.93, p < .05) would lessen the risk of ICH while the causality between IBD, CD, and ICH was unable to be established. Conclusion UC was causally related to ICH, but IBD and CD are not associated with ICH. The precise pathophysiological mechanism needs to be thoroughly investigated in more detail. |
| first_indexed | 2024-03-11T13:52:52Z |
| format | Article |
| id | doaj.art-0489b9874ad643d8bf3098bc1b43511f |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-03-11T13:52:52Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-0489b9874ad643d8bf3098bc1b43511f2023-11-02T07:56:19ZengWileyImmunity, Inflammation and Disease2050-45272023-10-011110n/an/a10.1002/iid3.1048Inflammatory bowel disease and the risk of intracerebral hemorrhage: A Mendelian randomization study and meta‐analysisYanju Song0Xuelun Zou1Yi Zeng2Le Zhang3Xinfa Mao4Department of Neurology Changsha Third Hospital Changsha Hunan ChinaDepartment of Neurology, Xiangya Hospital Central South University Changsha Hunan P.R. ChinaDepartment of Geriatrics, Second Xiangya Hospital Central South University Changsha Hunan P.R. ChinaDepartment of Neurology, Xiangya Hospital Central South University Changsha Hunan P.R. ChinaDepartment of Neurology Changsha Third Hospital Changsha Hunan ChinaAbstract Background The link between inflammatory bowel disease (IBD) and intracerebral hemorrhage (ICH) is still unclear. Aims We conducted a Mendelian randomization research and meta‐analysis to explore the impact of IBD and its subtypes (Crohn's disease [CD], ulcerative colitis [UC]) on the risk of ICH. Methods Two large genome‐wide association analysis studies of International Inflammatory Bowel Disease Genetics Consortium (IIBDGC) and International Stroke Genetics Consortium as exposure (IBD, UC, and CD) and outcome (ICH) in the initial stage. IBD, CD, UC GWAS data from the FinnGen consortium were adopted for the replication phase, and ultimately, the results of the initial stage and replication phase data were combined in a meta‐analysis to evaluate the causal association between IBD and its subtypes and the risk of ICH. Results In the initial stage, we found that in the IVW (odds ratio [OR] = 0.83, 95% confidence interval [CI]: 0.71–0.96, p = .01), MR‐PRESSO (OR = 0.85, 95% CI: 0.75–0.97, p = .02) and MR.RAPS (OR = 0.86, 95% CI: 0.76–0.98, p = .02) method showed that UC is associated with the risk of ICH. The causal relationship between IBD, CD, and the risk of ICH cannot be found by the IVW method. IBD and its subtypes UC, CD, and risk of ICH cannot find the presence of heterogeneity and pleiotropy. In replication stage, IBD (OR = 0.74, 95% CI: 0.59–0.94, p = .0135) related to ICH, while the IVW approach did not establish a causal link in UC and CD. The meta‐analysis still indicated that UC (OR = 0.83, 95% CI: 0.72–0.93, p < .05) would lessen the risk of ICH while the causality between IBD, CD, and ICH was unable to be established. Conclusion UC was causally related to ICH, but IBD and CD are not associated with ICH. The precise pathophysiological mechanism needs to be thoroughly investigated in more detail.https://doi.org/10.1002/iid3.1048Crohn's diseasegenome‐wide association analysisinflammatory bowel diseaseintracerebral hemorrhageMendelian randomizationulcerative colitis |
| spellingShingle | Yanju Song Xuelun Zou Yi Zeng Le Zhang Xinfa Mao Inflammatory bowel disease and the risk of intracerebral hemorrhage: A Mendelian randomization study and meta‐analysis Immunity, Inflammation and Disease Crohn's disease genome‐wide association analysis inflammatory bowel disease intracerebral hemorrhage Mendelian randomization ulcerative colitis |
| title | Inflammatory bowel disease and the risk of intracerebral hemorrhage: A Mendelian randomization study and meta‐analysis |
| title_full | Inflammatory bowel disease and the risk of intracerebral hemorrhage: A Mendelian randomization study and meta‐analysis |
| title_fullStr | Inflammatory bowel disease and the risk of intracerebral hemorrhage: A Mendelian randomization study and meta‐analysis |
| title_full_unstemmed | Inflammatory bowel disease and the risk of intracerebral hemorrhage: A Mendelian randomization study and meta‐analysis |
| title_short | Inflammatory bowel disease and the risk of intracerebral hemorrhage: A Mendelian randomization study and meta‐analysis |
| title_sort | inflammatory bowel disease and the risk of intracerebral hemorrhage a mendelian randomization study and meta analysis |
| topic | Crohn's disease genome‐wide association analysis inflammatory bowel disease intracerebral hemorrhage Mendelian randomization ulcerative colitis |
| url | https://doi.org/10.1002/iid3.1048 |
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