NOX activation in reactive astrocytes regulates astrocytic LCN2 expression and neurodegeneration

NOX activation in reactive astrocytes regulates astrocytic LCN2 expression and neurodegeneration

Abstract Reactive astrocytes (RA) secrete lipocalin-2 (LCN2) glycoprotein that regulates diverse cellular processes including cell death/survival, inflammation, iron delivery and cell differentiation. Elevated levels of LCN2 are considered as a biomarker of brain injury, however, the underlying regu...

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Bibliographic Details
Main Authors: Ruijia Liu, Jun Wang, Yang Chen, Jenelle M. Collier, Okan Capuk, Shijie Jin, Ming Sun, Sujan K. Mondal, Theresa L. Whiteside, Donna B. Stolz, Yongjie Yang, Gulnaz Begum
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04831-8

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