Irradiation of UVC LED at 277 nm inactivates coronaviruses in association to photodegradation of spike protein
To interrupt SARS-CoV-2 transmission chains, Ultraviolet-C (UVC) irradiation has emerged as a potential disinfection tool to aid in blocking the spread of coronaviruses. While conventional 254-nm UVC mercury lamps have been used for disinfection purposes, other UVC wavelengths have emerged as attrac...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022024203 |
| _version_ | 1797991595159584768 |
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| author | Qunxiang Ong J.W. Ronnie Teo Joshua Dela Cruz Elijah Wee Winson Wee Weiping Han |
| author_facet | Qunxiang Ong J.W. Ronnie Teo Joshua Dela Cruz Elijah Wee Winson Wee Weiping Han |
| author_sort | Qunxiang Ong |
| collection | DOAJ |
| description | To interrupt SARS-CoV-2 transmission chains, Ultraviolet-C (UVC) irradiation has emerged as a potential disinfection tool to aid in blocking the spread of coronaviruses. While conventional 254-nm UVC mercury lamps have been used for disinfection purposes, other UVC wavelengths have emerged as attractive alternatives but a direct comparison of these tools is lacking with the inherent mechanistic properties unclear. Our results using human coronaviruses, hCoV-229E and hCoV-OC43, have indicated that 277-nm UVC LED is most effective in viral inactivation, followed by 222-nm far UVC and 254-nm UVC mercury lamp. While UVC mercury lamp is more effective in degrading viral genomic content compared to 277-nm UVC LED, the latter results in a pronounced photo-degradation of spike proteins which potentially contributed to the higher efficacy of coronavirus inactivation. Hence, inactivation of coronaviruses by 277-nm UVC LED irradiation constitutes a more promising method for disinfection. |
| first_indexed | 2024-04-11T08:54:42Z |
| format | Article |
| id | doaj.art-048c71bd72044320ba57e33ac685cb6f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-11T08:54:42Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-048c71bd72044320ba57e33ac685cb6f2022-12-22T04:33:20ZengElsevierHeliyon2405-84402022-10-01810e11132Irradiation of UVC LED at 277 nm inactivates coronaviruses in association to photodegradation of spike proteinQunxiang Ong0J.W. Ronnie Teo1Joshua Dela Cruz2Elijah Wee3Winson Wee4Weiping Han5Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), 11 Biopolis Way, #02-02, Helios, 138667, Singapore; Corresponding author.Singapore Institute of Manufacturing Technology (SIMTech), Agency for Science, Technology and Research (A∗STAR), 2 Fusionopolis Way, #08-04, Innovis, 138634, SingaporeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), 11 Biopolis Way, #02-02, Helios, 138667, SingaporeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), 11 Biopolis Way, #02-02, Helios, 138667, SingaporeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), 11 Biopolis Way, #02-02, Helios, 138667, SingaporeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), 11 Biopolis Way, #02-02, Helios, 138667, Singapore; Corresponding author.To interrupt SARS-CoV-2 transmission chains, Ultraviolet-C (UVC) irradiation has emerged as a potential disinfection tool to aid in blocking the spread of coronaviruses. While conventional 254-nm UVC mercury lamps have been used for disinfection purposes, other UVC wavelengths have emerged as attractive alternatives but a direct comparison of these tools is lacking with the inherent mechanistic properties unclear. Our results using human coronaviruses, hCoV-229E and hCoV-OC43, have indicated that 277-nm UVC LED is most effective in viral inactivation, followed by 222-nm far UVC and 254-nm UVC mercury lamp. While UVC mercury lamp is more effective in degrading viral genomic content compared to 277-nm UVC LED, the latter results in a pronounced photo-degradation of spike proteins which potentially contributed to the higher efficacy of coronavirus inactivation. Hence, inactivation of coronaviruses by 277-nm UVC LED irradiation constitutes a more promising method for disinfection.http://www.sciencedirect.com/science/article/pii/S2405844022024203UVC disinfectionSpike proteinCoronavirus277-Nm LEDPhotodegradation |
| spellingShingle | Qunxiang Ong J.W. Ronnie Teo Joshua Dela Cruz Elijah Wee Winson Wee Weiping Han Irradiation of UVC LED at 277 nm inactivates coronaviruses in association to photodegradation of spike protein Heliyon UVC disinfection Spike protein Coronavirus 277-Nm LED Photodegradation |
| title | Irradiation of UVC LED at 277 nm inactivates coronaviruses in association to photodegradation of spike protein |
| title_full | Irradiation of UVC LED at 277 nm inactivates coronaviruses in association to photodegradation of spike protein |
| title_fullStr | Irradiation of UVC LED at 277 nm inactivates coronaviruses in association to photodegradation of spike protein |
| title_full_unstemmed | Irradiation of UVC LED at 277 nm inactivates coronaviruses in association to photodegradation of spike protein |
| title_short | Irradiation of UVC LED at 277 nm inactivates coronaviruses in association to photodegradation of spike protein |
| title_sort | irradiation of uvc led at 277 nm inactivates coronaviruses in association to photodegradation of spike protein |
| topic | UVC disinfection Spike protein Coronavirus 277-Nm LED Photodegradation |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022024203 |
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