Effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal model
Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective destruction of pancreatic beta cells. In addition to genetic factors, enteroviruses have been considered the main environmental factor involved in this pathology. Therefore, the objective of this study was to evaluate the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade Estadual de Maringá
2019-07-01
|
| Series: | Acta Scientiarum: Biological Sciences |
| Subjects: | |
| Online Access: | https://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43765 |
| _version_ | 1811229491442221056 |
|---|---|
| author | Thaís Dalzochio Otto Henrique Nienov Clovis Wannmacher Daiane Bolzan Berlese Luciane Rosa Feksa |
| author_facet | Thaís Dalzochio Otto Henrique Nienov Clovis Wannmacher Daiane Bolzan Berlese Luciane Rosa Feksa |
| author_sort | Thaís Dalzochio |
| collection | DOAJ |
| description |
Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective destruction of pancreatic beta cells. In addition to genetic factors, enteroviruses have been considered the main environmental factor involved in this pathology. Therefore, the objective of this study was to evaluate the effects of streptozotocin-induced diabetes and bovine enterovirus (BEV) on liver and kidney pyruvate kinase activity in rats. Fourteen male Wistar rats were divided in three groups: control, diabetes and a third group, which was fed with water experimentally contaminated by BEV. Increased blood glucose levels were found in both diabetes and enterovirus groups, whereas there were no alterations in the lipid profile. A reduced pyruvate kinase activity was observed in the liver and kidney of animals from diabetes and enterovirus groups. Under our experimental conditions, the ingestion of water experimentally contaminated by BEV induced alterations in glycaemia, and also interfered in the pyruvate kinase activity in liver and kidney of the rats, which might be one of the possible mechanisms involved in the T1D development.
|
| first_indexed | 2024-04-12T10:15:25Z |
| format | Article |
| id | doaj.art-048db204a71f41f69b11431773f7f0bd |
| institution | Directory Open Access Journal |
| issn | 1679-9283 1807-863X |
| language | English |
| last_indexed | 2024-04-12T10:15:25Z |
| publishDate | 2019-07-01 |
| publisher | Universidade Estadual de Maringá |
| record_format | Article |
| series | Acta Scientiarum: Biological Sciences |
| spelling | doaj.art-048db204a71f41f69b11431773f7f0bd2022-12-22T03:37:12ZengUniversidade Estadual de MaringáActa Scientiarum: Biological Sciences1679-92831807-863X2019-07-0141110.4025/actascibiolsci.v41i1.4376543765Effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal modelThaís Dalzochio0Otto Henrique Nienov1Clovis Wannmacher2Daiane Bolzan Berlese3Luciane Rosa Feksa4Universidade FeevaleUniversidade FeevaleUniversidade Federal do Rio Grande do SulUniversidade FeevaleUniversidade Feevale / Universidade Federal do Rio Grande do Sul Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective destruction of pancreatic beta cells. In addition to genetic factors, enteroviruses have been considered the main environmental factor involved in this pathology. Therefore, the objective of this study was to evaluate the effects of streptozotocin-induced diabetes and bovine enterovirus (BEV) on liver and kidney pyruvate kinase activity in rats. Fourteen male Wistar rats were divided in three groups: control, diabetes and a third group, which was fed with water experimentally contaminated by BEV. Increased blood glucose levels were found in both diabetes and enterovirus groups, whereas there were no alterations in the lipid profile. A reduced pyruvate kinase activity was observed in the liver and kidney of animals from diabetes and enterovirus groups. Under our experimental conditions, the ingestion of water experimentally contaminated by BEV induced alterations in glycaemia, and also interfered in the pyruvate kinase activity in liver and kidney of the rats, which might be one of the possible mechanisms involved in the T1D development. https://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43765animal modelautoimmune diseaseenzymatic activity. |
| spellingShingle | Thaís Dalzochio Otto Henrique Nienov Clovis Wannmacher Daiane Bolzan Berlese Luciane Rosa Feksa Effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal model Acta Scientiarum: Biological Sciences animal model autoimmune disease enzymatic activity. |
| title | Effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal model |
| title_full | Effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal model |
| title_fullStr | Effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal model |
| title_full_unstemmed | Effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal model |
| title_short | Effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal model |
| title_sort | effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal model |
| topic | animal model autoimmune disease enzymatic activity. |
| url | https://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43765 |
| work_keys_str_mv | AT thaisdalzochio effectsofbovineenterovirusandtype1diabetesonliverandkidneypyruvatekinaseactivityinananimalmodel AT ottohenriquenienov effectsofbovineenterovirusandtype1diabetesonliverandkidneypyruvatekinaseactivityinananimalmodel AT cloviswannmacher effectsofbovineenterovirusandtype1diabetesonliverandkidneypyruvatekinaseactivityinananimalmodel AT daianebolzanberlese effectsofbovineenterovirusandtype1diabetesonliverandkidneypyruvatekinaseactivityinananimalmodel AT lucianerosafeksa effectsofbovineenterovirusandtype1diabetesonliverandkidneypyruvatekinaseactivityinananimalmodel |