Efficient and stable CRISPR/Cas9-mediated genome-editing of human type 2 innate lymphoid cells

Efficient and stable CRISPR/Cas9-mediated genome-editing of human type 2 innate lymphoid cells

Innate lymphoid cells (ILCs) are a family of innate lymphocytes with important roles in immune response coordination and maintenance of tissue homeostasis. The ILC family includes group 1 (ILC1s), group 2 (ILC2s) and group 3 (ILC3s) ‘helper’ ILCs, as well as cytotoxic Natural Killer (NK) cells. Stud...

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Bibliographic Details
Main Authors: Johanne Audouze-Chaud, Jessica A. Mathews, Sarah Q. Crome
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
innate lymphoid cells
ILC2s
natural killer cells
CRISPR/Cas9
nucleofection
IL-4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275413/full

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