OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo
Abstract Carbapenem-resistance in Klebsiella pneumoniae (KP) sequence type ST258 is mediated by carbapenemases (e.g. KPC-2) and loss or modification of the major non-selective porins OmpK35 and OmpK36. However, the mechanism underpinning OmpK36-mediated resistance and consequences of these changes o...
Main Authors: | Joshua L. C. Wong, Maria Romano, Louise E. Kerry, Hok-Sau Kwong, Wen-Wen Low, Stephen J. Brett, Abigail Clements, Konstantinos Beis, Gad Frankel |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2019-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-11756-y |
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