Development and Validation of an Up-to-Date Highly Sensitive UHPLC-MS/MS Method for the Simultaneous Quantification of Current Anti-HIV Nucleoside Analogues in Human Plasma

Development and Validation of an Up-to-Date Highly Sensitive UHPLC-MS/MS Method for the Simultaneous Quantification of Current Anti-HIV Nucleoside Analogues in Human Plasma

Therapeutic options to treat HIV infection have widened in the past years, improving both effectiveness and tolerability, but nucleoside reverse transcriptase inhibitors (NRTIs) are still considered the standard backbone of the combination regimens. Therapeutic drug monitoring (TDM) can be useful fo...

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Bibliographic Details
Main Authors: Amedeo De Nicolò, Alessandra Manca, Alice Ianniello, Alice Palermiti, Andrea Calcagno, Micol Ferrara, Miriam Antonucci, Jessica Cusato, Valeria Avataneo, Elisa De Vivo, Stefano Bonora, Francesco Giuseppe De Rosa, Giovanni Di Perri, Antonio D’Avolio
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceuticals
Subjects:
liquid chromatography
tandem mass spectrometry
tenofovir alafenamide
nucleoside analogues
NRTIs
Online Access:https://www.mdpi.com/1424-8247/14/5/460

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