Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide
Abstract Background Several hypnotic drugs have been previously identified as modulators of food intake, but exact mechanisms remain unknown. Feeding behavior implicates several neuronal populations in the hypothalamic arcuate nucleus including orexigenic neuropeptide Y and anorexigenic pro-opiomela...
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | BMC Anesthesiology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12871-018-0557-x |
| _version_ | 1818286930820857856 |
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| author | E. Besnier T. Clavier M. C. Tonon G. Pelletier B. Dureuil H. Castel V. Compère |
| author_facet | E. Besnier T. Clavier M. C. Tonon G. Pelletier B. Dureuil H. Castel V. Compère |
| author_sort | E. Besnier |
| collection | DOAJ |
| description | Abstract Background Several hypnotic drugs have been previously identified as modulators of food intake, but exact mechanisms remain unknown. Feeding behavior implicates several neuronal populations in the hypothalamic arcuate nucleus including orexigenic neuropeptide Y and anorexigenic pro-opiomelanocortin producing neurons. The aim of this study was to investigate in mice the impact of different hypnotic drugs on food consumption and neuropeptide Y or pro-opiomelanocortine mRNA expression level in the hypothalamic arcuate nucleus. Methods Saline control, isoflurane, thiopental, midazolam or propofol were administered to C57Bl/6 mice. Feeding behavior was evaluated during 6 h. In situ hybridization of neuropeptide Y and pro-opiomelanocortine mRNAs in the hypothalamus brain region was also performed. Data were analyzed by Kruskal Wallis test and analysis of variance (p < 0.05). Results Midazolam, thiopental and propofol induced feeding behavior. Midazolam and thiopental increased neuropeptide Y mRNA level (respectively by 106 and 125%, p < 0.001) compared with control. Propofol and midazolam decreased pro-opiomelanocortine mRNA level by 31% (p < 0,01) compared with control. Isoflurane increased pro-opiomelanocortine mRNA level by 40% compared with control. Conclusion In our murine model, most hypnotics induced food consumption. The hypnotic-induced regulation of neuropeptide Y and pro-opiomelanocortine hypothalamic peptides is associated with this finding. Our data suggest that administration of some hypnotic drugs may affect hypothalamic peptide precursor and neuropeptide expression and concomittantly modulate food intake. Thus, this questions the choice of anesthetics for better care management of patients undergoing major surgery or at risk of undernutrition. |
| first_indexed | 2024-12-13T01:32:25Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-12-13T01:32:25Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-04913b7a571b4ef79003b775bf49b7e02022-12-22T00:03:57ZengBMCBMC Anesthesiology1471-22532018-07-011811710.1186/s12871-018-0557-xAnesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptideE. Besnier0T. Clavier1M. C. Tonon2G. Pelletier3B. Dureuil4H. Castel5V. Compère6Normandie Univ, UNIROUEN, INSERM U1239, DC2NNormandie Univ, UNIROUEN, INSERM U1239, DC2NNormandie Univ, UNIROUEN, INSERM U1239, DC2NResearch Center in Molecular Endocrinology, Oncology and Genetics, Laval University Hospital CenterDepartment of Anesthesiology and Critical Care, Rouen University HospitalNormandie Univ, UNIROUEN, INSERM U1239, DC2NNormandie Univ, UNIROUEN, INSERM U1239, DC2NAbstract Background Several hypnotic drugs have been previously identified as modulators of food intake, but exact mechanisms remain unknown. Feeding behavior implicates several neuronal populations in the hypothalamic arcuate nucleus including orexigenic neuropeptide Y and anorexigenic pro-opiomelanocortin producing neurons. The aim of this study was to investigate in mice the impact of different hypnotic drugs on food consumption and neuropeptide Y or pro-opiomelanocortine mRNA expression level in the hypothalamic arcuate nucleus. Methods Saline control, isoflurane, thiopental, midazolam or propofol were administered to C57Bl/6 mice. Feeding behavior was evaluated during 6 h. In situ hybridization of neuropeptide Y and pro-opiomelanocortine mRNAs in the hypothalamus brain region was also performed. Data were analyzed by Kruskal Wallis test and analysis of variance (p < 0.05). Results Midazolam, thiopental and propofol induced feeding behavior. Midazolam and thiopental increased neuropeptide Y mRNA level (respectively by 106 and 125%, p < 0.001) compared with control. Propofol and midazolam decreased pro-opiomelanocortine mRNA level by 31% (p < 0,01) compared with control. Isoflurane increased pro-opiomelanocortine mRNA level by 40% compared with control. Conclusion In our murine model, most hypnotics induced food consumption. The hypnotic-induced regulation of neuropeptide Y and pro-opiomelanocortine hypothalamic peptides is associated with this finding. Our data suggest that administration of some hypnotic drugs may affect hypothalamic peptide precursor and neuropeptide expression and concomittantly modulate food intake. Thus, this questions the choice of anesthetics for better care management of patients undergoing major surgery or at risk of undernutrition.http://link.springer.com/article/10.1186/s12871-018-0557-xAnestheticsFeeding behaviorNeuropeptide YPro-opiomelanocortinArcuate nucleus |
| spellingShingle | E. Besnier T. Clavier M. C. Tonon G. Pelletier B. Dureuil H. Castel V. Compère Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide BMC Anesthesiology Anesthetics Feeding behavior Neuropeptide Y Pro-opiomelanocortin Arcuate nucleus |
| title | Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide |
| title_full | Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide |
| title_fullStr | Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide |
| title_full_unstemmed | Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide |
| title_short | Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide |
| title_sort | anesthetic drugs modulate feeding behavior and hypothalamic expression of the pomc polypeptide precursor and the npy neuropeptide |
| topic | Anesthetics Feeding behavior Neuropeptide Y Pro-opiomelanocortin Arcuate nucleus |
| url | http://link.springer.com/article/10.1186/s12871-018-0557-x |
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