New aspects of the pathogenesis of psoriasis
Psoriasis is a chronic multi-factorial immune-mediated inflammatory disease of skin and joints. The variety of clinical forms of dermatosis is consistent with various pathogenetic features of the disease progress which have been significantly supplemented and reviewed recently. Knowledge of these me...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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State Scientific Center of Dermatovenereology and Cosmetology
2022-09-01
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| Series: | Vestnik Dermatologii i Venerologii |
| Subjects: | |
| Online Access: | https://vestnikdv.ru/jour/article/viewFile/1345/pdf |
| _version_ | 1797723815355088896 |
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| author | Alexander S. Zhukov Alexander V. Patrushev Vladislav R. Khairutdinov Alexey V. Samtsov Evgeniy V. Kryukov |
| author_facet | Alexander S. Zhukov Alexander V. Patrushev Vladislav R. Khairutdinov Alexey V. Samtsov Evgeniy V. Kryukov |
| author_sort | Alexander S. Zhukov |
| collection | DOAJ |
| description | Psoriasis is a chronic multi-factorial immune-mediated inflammatory disease of skin and joints. The variety of clinical forms of dermatosis is consistent with various pathogenetic features of the disease progress which have been significantly supplemented and reviewed recently. Knowledge of these mechanisms will improve and personalize the prescribed therapy.
This study places the emphasis on modern ideas about the formation of T cell memory, the role of melanocytes and innate lymphoid cells. Development mechanisms of guttate and paradoxical psoriasis with important distinguishing characteristics are described separately.
Today, knowledge of the molecular basis of the disease progression has led to the creation and introduction of a number of highly effective targeted drugs into clinical practice. Further developments related to the inhibition of resident memory cells, innate lymphoid cells, as well as the study of guttate psoriasis perpetuation and the occurrence of paradoxical psoriasis will significantly increase the effectiveness of the therapy. |
| first_indexed | 2024-03-12T10:07:00Z |
| format | Article |
| id | doaj.art-049160884a5b46209aa355ea693006de |
| institution | Directory Open Access Journal |
| issn | 0042-4609 2313-6294 |
| language | English |
| last_indexed | 2024-03-12T10:07:00Z |
| publishDate | 2022-09-01 |
| publisher | State Scientific Center of Dermatovenereology and Cosmetology |
| record_format | Article |
| series | Vestnik Dermatologii i Venerologii |
| spelling | doaj.art-049160884a5b46209aa355ea693006de2023-09-02T11:06:09ZengState Scientific Center of Dermatovenereology and CosmetologyVestnik Dermatologii i Venerologii0042-46092313-62942022-09-01984314010.25208/vdv13451175New aspects of the pathogenesis of psoriasisAlexander S. Zhukov0https://orcid.org/0000-0002-4915-9157Alexander V. Patrushev1https://orcid.org/0000-0002-6989-9363Vladislav R. Khairutdinov2https://orcid.org/0000-0002-0387-5481Alexey V. Samtsov3https://orcid.org/0000-0002-9458-0872Evgeniy V. Kryukov4https://orcid.org/0000-0002-8396-1936S.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyPsoriasis is a chronic multi-factorial immune-mediated inflammatory disease of skin and joints. The variety of clinical forms of dermatosis is consistent with various pathogenetic features of the disease progress which have been significantly supplemented and reviewed recently. Knowledge of these mechanisms will improve and personalize the prescribed therapy. This study places the emphasis on modern ideas about the formation of T cell memory, the role of melanocytes and innate lymphoid cells. Development mechanisms of guttate and paradoxical psoriasis with important distinguishing characteristics are described separately. Today, knowledge of the molecular basis of the disease progression has led to the creation and introduction of a number of highly effective targeted drugs into clinical practice. Further developments related to the inhibition of resident memory cells, innate lymphoid cells, as well as the study of guttate psoriasis perpetuation and the occurrence of paradoxical psoriasis will significantly increase the effectiveness of the therapy.https://vestnikdv.ru/jour/article/viewFile/1345/pdfpsoriasispathogenesist-cell memoryinnate lymphoid cellsmelanocytesguttate psoriasisparadoxical psoriasis |
| spellingShingle | Alexander S. Zhukov Alexander V. Patrushev Vladislav R. Khairutdinov Alexey V. Samtsov Evgeniy V. Kryukov New aspects of the pathogenesis of psoriasis Vestnik Dermatologii i Venerologii psoriasis pathogenesis t-cell memory innate lymphoid cells melanocytes guttate psoriasis paradoxical psoriasis |
| title | New aspects of the pathogenesis of psoriasis |
| title_full | New aspects of the pathogenesis of psoriasis |
| title_fullStr | New aspects of the pathogenesis of psoriasis |
| title_full_unstemmed | New aspects of the pathogenesis of psoriasis |
| title_short | New aspects of the pathogenesis of psoriasis |
| title_sort | new aspects of the pathogenesis of psoriasis |
| topic | psoriasis pathogenesis t-cell memory innate lymphoid cells melanocytes guttate psoriasis paradoxical psoriasis |
| url | https://vestnikdv.ru/jour/article/viewFile/1345/pdf |
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