Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw
Aim: This article covers the authors' experience with the treatment of bisphosphonate-related osteonecrosis of the jaw in 11 individuals. Methods: A retrospective study of patients diagnosed and treated for bisphosphonate-related osteonecrosis of the jaw at the Department of Dentistry, Universi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2015-06-01
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| Series: | Biomedical Papers |
| Subjects: | |
| Online Access: | https://biomed.papers.upol.cz/artkey/bio-201502-0025_Experience_with_the_treatment_of_bisphosphonate-related_osteonecrosis_of_the_jaw.php |
| _version_ | 1818292584504623104 |
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| author | Zuzana Janovska Radovan Mottl Radovan Slezak |
| author_facet | Zuzana Janovska Radovan Mottl Radovan Slezak |
| author_sort | Zuzana Janovska |
| collection | DOAJ |
| description | Aim: This article covers the authors' experience with the treatment of bisphosphonate-related osteonecrosis of the jaw in 11 individuals.
Methods: A retrospective study of patients diagnosed and treated for bisphosphonate-related osteonecrosis of the jaw at the Department of Dentistry, University Hospital Hradec Králové during the period January 2006 to October 2012. The treatment protocol consisted of antimicrobial mouth rinses and systemic antibiotic administration according to the stage of the disease. Additional surgical debridement and sequestrectomy in combination with antimicrobial therapy was performed in two cases.
Results: Complete healing was achieved in six patients. In two cases, satisfactory healing was noted. Stage of the disease was lowered and only a small area of asymptomatic necrotic bone of up to five mm in diameter persisted. Two patients developed a stable disease without progression. In one patient, the disease progressed to the third stage with osteonecrosis involving all quadrants of both jaws.
Conclusion: From these data it was concluded that conservative approach in the treatment of bisphosphonate-related osteonecrosis of the jaw led to symptom regression but was not curative. Surgical intervention, however, bears the risk of further progression of the osteonecrosis and must be carefully planned with respect to the patient's general health status and life expectancy. The treatment of bisphosphonate-related osteonecrosis of the jaw is generally difficult. For this reason, prevention plays a predominant role in the management of the disease. |
| first_indexed | 2024-12-13T03:02:17Z |
| format | Article |
| id | doaj.art-0493cae69418494485cadc707f180110 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-13T03:02:17Z |
| publishDate | 2015-06-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-0493cae69418494485cadc707f1801102022-12-22T00:01:48ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212015-06-01159231331710.5507/bp.2013.069bio-201502-0025Experience with the treatment of bisphosphonate-related osteonecrosis of the jawZuzana Janovska0Radovan Mottl1Radovan Slezak2Department of Dentistry, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech RepublicDepartment of Dentistry, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech RepublicDepartment of Dentistry, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech RepublicAim: This article covers the authors' experience with the treatment of bisphosphonate-related osteonecrosis of the jaw in 11 individuals. Methods: A retrospective study of patients diagnosed and treated for bisphosphonate-related osteonecrosis of the jaw at the Department of Dentistry, University Hospital Hradec Králové during the period January 2006 to October 2012. The treatment protocol consisted of antimicrobial mouth rinses and systemic antibiotic administration according to the stage of the disease. Additional surgical debridement and sequestrectomy in combination with antimicrobial therapy was performed in two cases. Results: Complete healing was achieved in six patients. In two cases, satisfactory healing was noted. Stage of the disease was lowered and only a small area of asymptomatic necrotic bone of up to five mm in diameter persisted. Two patients developed a stable disease without progression. In one patient, the disease progressed to the third stage with osteonecrosis involving all quadrants of both jaws. Conclusion: From these data it was concluded that conservative approach in the treatment of bisphosphonate-related osteonecrosis of the jaw led to symptom regression but was not curative. Surgical intervention, however, bears the risk of further progression of the osteonecrosis and must be carefully planned with respect to the patient's general health status and life expectancy. The treatment of bisphosphonate-related osteonecrosis of the jaw is generally difficult. For this reason, prevention plays a predominant role in the management of the disease.https://biomed.papers.upol.cz/artkey/bio-201502-0025_Experience_with_the_treatment_of_bisphosphonate-related_osteonecrosis_of_the_jaw.phpbronjbisphosphonatesosteonecrosisjawtreatment |
| spellingShingle | Zuzana Janovska Radovan Mottl Radovan Slezak Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw Biomedical Papers bronj bisphosphonates osteonecrosis jaw treatment |
| title | Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw |
| title_full | Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw |
| title_fullStr | Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw |
| title_full_unstemmed | Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw |
| title_short | Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw |
| title_sort | experience with the treatment of bisphosphonate related osteonecrosis of the jaw |
| topic | bronj bisphosphonates osteonecrosis jaw treatment |
| url | https://biomed.papers.upol.cz/artkey/bio-201502-0025_Experience_with_the_treatment_of_bisphosphonate-related_osteonecrosis_of_the_jaw.php |
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