Acute interstitial nephritis with acetaminophen and alcohol intoxication

<p>Abstract</p> <p>Drug-induced acute interstitial nephritis (AIN) represents a growing cause of renal failure in current medical practice. While antimicrobials and non-steroidal anti-inflammatory drugs are typically associated with drug-induced AIN, few reports have been made on t...

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Main Authors: Alexopoulou Iakovina, Fruchter Lauren L, Lau Keith K
Format: Article
Language:English
Published: BMC 2011-04-01
Series:Italian Journal of Pediatrics
Subjects:
Online Access:http://www.ijponline.net/content/37/1/17
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author Alexopoulou Iakovina
Fruchter Lauren L
Lau Keith K
author_facet Alexopoulou Iakovina
Fruchter Lauren L
Lau Keith K
author_sort Alexopoulou Iakovina
collection DOAJ
description <p>Abstract</p> <p>Drug-induced acute interstitial nephritis (AIN) represents a growing cause of renal failure in current medical practice. While antimicrobials and non-steroidal anti-inflammatory drugs are typically associated with drug-induced AIN, few reports have been made on the involvement of other analgesics. We report our experience in managing a 17-year-old female with AIN and subsequent renal injury following an acetaminophen overdose in conjunction with acute alcohol intoxication. It is well established that acetaminophen metabolism, particularly at high doses, produces reactive metabolites that may induce renal and hepatic toxicity. It is also plausible however, that such reactive species could instead alter renal peptide immunogenicity, thereby inducing AIN. In the following report, we review a possible mechanism for the acetaminophen-induced AIN observed in our patient and also discuss the potential involvement of acute alcohol ingestion in disease onset. The objective of our report is to increase awareness of healthcare professionals to the potential involvement of these commonly used agents in AIN pathogenesis.</p>
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spelling doaj.art-0496384c486b4053bcb6dd1ac228605a2022-12-21T18:48:48ZengBMCItalian Journal of Pediatrics1720-84241824-72882011-04-013711710.1186/1824-7288-37-17Acute interstitial nephritis with acetaminophen and alcohol intoxicationAlexopoulou IakovinaFruchter Lauren LLau Keith K<p>Abstract</p> <p>Drug-induced acute interstitial nephritis (AIN) represents a growing cause of renal failure in current medical practice. While antimicrobials and non-steroidal anti-inflammatory drugs are typically associated with drug-induced AIN, few reports have been made on the involvement of other analgesics. We report our experience in managing a 17-year-old female with AIN and subsequent renal injury following an acetaminophen overdose in conjunction with acute alcohol intoxication. It is well established that acetaminophen metabolism, particularly at high doses, produces reactive metabolites that may induce renal and hepatic toxicity. It is also plausible however, that such reactive species could instead alter renal peptide immunogenicity, thereby inducing AIN. In the following report, we review a possible mechanism for the acetaminophen-induced AIN observed in our patient and also discuss the potential involvement of acute alcohol ingestion in disease onset. The objective of our report is to increase awareness of healthcare professionals to the potential involvement of these commonly used agents in AIN pathogenesis.</p>http://www.ijponline.net/content/37/1/17drug induced hypersensitivityacetaminophenrenal injuryacute interstitial nephritisalcohol
spellingShingle Alexopoulou Iakovina
Fruchter Lauren L
Lau Keith K
Acute interstitial nephritis with acetaminophen and alcohol intoxication
Italian Journal of Pediatrics
drug induced hypersensitivity
acetaminophen
renal injury
acute interstitial nephritis
alcohol
title Acute interstitial nephritis with acetaminophen and alcohol intoxication
title_full Acute interstitial nephritis with acetaminophen and alcohol intoxication
title_fullStr Acute interstitial nephritis with acetaminophen and alcohol intoxication
title_full_unstemmed Acute interstitial nephritis with acetaminophen and alcohol intoxication
title_short Acute interstitial nephritis with acetaminophen and alcohol intoxication
title_sort acute interstitial nephritis with acetaminophen and alcohol intoxication
topic drug induced hypersensitivity
acetaminophen
renal injury
acute interstitial nephritis
alcohol
url http://www.ijponline.net/content/37/1/17
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AT fruchterlaurenl acuteinterstitialnephritiswithacetaminophenandalcoholintoxication
AT laukeithk acuteinterstitialnephritiswithacetaminophenandalcoholintoxication