Acute interstitial nephritis with acetaminophen and alcohol intoxication
<p>Abstract</p> <p>Drug-induced acute interstitial nephritis (AIN) represents a growing cause of renal failure in current medical practice. While antimicrobials and non-steroidal anti-inflammatory drugs are typically associated with drug-induced AIN, few reports have been made on t...
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Format: | Article |
Language: | English |
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BMC
2011-04-01
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Series: | Italian Journal of Pediatrics |
Subjects: | |
Online Access: | http://www.ijponline.net/content/37/1/17 |
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author | Alexopoulou Iakovina Fruchter Lauren L Lau Keith K |
author_facet | Alexopoulou Iakovina Fruchter Lauren L Lau Keith K |
author_sort | Alexopoulou Iakovina |
collection | DOAJ |
description | <p>Abstract</p> <p>Drug-induced acute interstitial nephritis (AIN) represents a growing cause of renal failure in current medical practice. While antimicrobials and non-steroidal anti-inflammatory drugs are typically associated with drug-induced AIN, few reports have been made on the involvement of other analgesics. We report our experience in managing a 17-year-old female with AIN and subsequent renal injury following an acetaminophen overdose in conjunction with acute alcohol intoxication. It is well established that acetaminophen metabolism, particularly at high doses, produces reactive metabolites that may induce renal and hepatic toxicity. It is also plausible however, that such reactive species could instead alter renal peptide immunogenicity, thereby inducing AIN. In the following report, we review a possible mechanism for the acetaminophen-induced AIN observed in our patient and also discuss the potential involvement of acute alcohol ingestion in disease onset. The objective of our report is to increase awareness of healthcare professionals to the potential involvement of these commonly used agents in AIN pathogenesis.</p> |
first_indexed | 2024-12-21T22:02:15Z |
format | Article |
id | doaj.art-0496384c486b4053bcb6dd1ac228605a |
institution | Directory Open Access Journal |
issn | 1720-8424 1824-7288 |
language | English |
last_indexed | 2024-12-21T22:02:15Z |
publishDate | 2011-04-01 |
publisher | BMC |
record_format | Article |
series | Italian Journal of Pediatrics |
spelling | doaj.art-0496384c486b4053bcb6dd1ac228605a2022-12-21T18:48:48ZengBMCItalian Journal of Pediatrics1720-84241824-72882011-04-013711710.1186/1824-7288-37-17Acute interstitial nephritis with acetaminophen and alcohol intoxicationAlexopoulou IakovinaFruchter Lauren LLau Keith K<p>Abstract</p> <p>Drug-induced acute interstitial nephritis (AIN) represents a growing cause of renal failure in current medical practice. While antimicrobials and non-steroidal anti-inflammatory drugs are typically associated with drug-induced AIN, few reports have been made on the involvement of other analgesics. We report our experience in managing a 17-year-old female with AIN and subsequent renal injury following an acetaminophen overdose in conjunction with acute alcohol intoxication. It is well established that acetaminophen metabolism, particularly at high doses, produces reactive metabolites that may induce renal and hepatic toxicity. It is also plausible however, that such reactive species could instead alter renal peptide immunogenicity, thereby inducing AIN. In the following report, we review a possible mechanism for the acetaminophen-induced AIN observed in our patient and also discuss the potential involvement of acute alcohol ingestion in disease onset. The objective of our report is to increase awareness of healthcare professionals to the potential involvement of these commonly used agents in AIN pathogenesis.</p>http://www.ijponline.net/content/37/1/17drug induced hypersensitivityacetaminophenrenal injuryacute interstitial nephritisalcohol |
spellingShingle | Alexopoulou Iakovina Fruchter Lauren L Lau Keith K Acute interstitial nephritis with acetaminophen and alcohol intoxication Italian Journal of Pediatrics drug induced hypersensitivity acetaminophen renal injury acute interstitial nephritis alcohol |
title | Acute interstitial nephritis with acetaminophen and alcohol intoxication |
title_full | Acute interstitial nephritis with acetaminophen and alcohol intoxication |
title_fullStr | Acute interstitial nephritis with acetaminophen and alcohol intoxication |
title_full_unstemmed | Acute interstitial nephritis with acetaminophen and alcohol intoxication |
title_short | Acute interstitial nephritis with acetaminophen and alcohol intoxication |
title_sort | acute interstitial nephritis with acetaminophen and alcohol intoxication |
topic | drug induced hypersensitivity acetaminophen renal injury acute interstitial nephritis alcohol |
url | http://www.ijponline.net/content/37/1/17 |
work_keys_str_mv | AT alexopoulouiakovina acuteinterstitialnephritiswithacetaminophenandalcoholintoxication AT fruchterlaurenl acuteinterstitialnephritiswithacetaminophenandalcoholintoxication AT laukeithk acuteinterstitialnephritiswithacetaminophenandalcoholintoxication |