Candidate Genes Encoding Dopamine Receptors as Predictors of the Risk of Antipsychotic-Induced Parkinsonism and Tardive Dyskinesia in Schizophrenic Patients
(1) Introduction: Extrapyramidal disorders form the so-called extrapyramidal syndrome (EPS), which is characterized by the occurrence of motor disorders as a result of damage to the basal ganglia and the subcortical-thalamic connections. Often, this syndrome develops while taking medications, in par...
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MDPI AG
2021-07-01
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| author | Elena E. Vaiman Natalia A. Shnayder Maxim A. Novitsky Vera S. Dobrodeeva Polina S. Goncharova Elena N. Bochanova Margarita R. Sapronova Tatiana E. Popova Alexey A. Tappakhov Regina F. Nasyrova |
| author_facet | Elena E. Vaiman Natalia A. Shnayder Maxim A. Novitsky Vera S. Dobrodeeva Polina S. Goncharova Elena N. Bochanova Margarita R. Sapronova Tatiana E. Popova Alexey A. Tappakhov Regina F. Nasyrova |
| author_sort | Elena E. Vaiman |
| collection | DOAJ |
| description | (1) Introduction: Extrapyramidal disorders form the so-called extrapyramidal syndrome (EPS), which is characterized by the occurrence of motor disorders as a result of damage to the basal ganglia and the subcortical-thalamic connections. Often, this syndrome develops while taking medications, in particular antipsychotics (APs). (2) Purpose: To review studies of candidate genes encoding dopamine receptors as genetic predictors of development of AP-induced parkinsonism (AIP) and AP-induced tardive dyskinesia (AITD) in patients with schizophrenia. (3) Materials and Methods: A search was carried out for publications of PubMed, Web of Science, Springer, and e-Library databases by keywords and their combinations over the last 10 years. In addition, the review includes earlier publications of historical interest. Despite extensive searches of these commonly used databases and search terms, it cannot be ruled out that some publications were possibly missed. (4) Results: The review considers candidate genes encoding dopamine receptors involved in pharmacodynamics, including genes <i>DRD1</i>, <i>DRD2</i>, <i>DRD3</i>, and <i>DRD4</i>. We analyzed 18 genome-wide studies examining 37 genetic variations, including single nucleotide variants (SNVs)/polymorphisms of four candidate genes involved in the development of AIP and AITD in patients with schizophrenia. Among such a set of obtained results, only 14 positive associations were revealed: rs1799732 (141CIns/Del), rs1800497 (C/T), rs6275 (C/T), rs6275 (C/T) <i>DRD2</i>; rs167771 (G/A) <i>DRD3</i> with AIP and rs4532 (A/G) <i>DRD1</i>, rs6277 (C/T), rs6275 (C/T), rs1800497 (C/T), rs1079597 (A/G), rs1799732 (141CIns/Del), rs1045280 (C/G) <i>DRD2</i>, rs6280 (C/T), rs905568 (C/G) <i>DRD3</i> with AITD. However, at present, it should be recognized that there is no final or unique decision on the leading role of any particular SNVs/polymorphisms in the development of AIP and AITD. (5) Conclusion: Disclosure of genetic predictors of the development of AIP and AITD, as the most common neurological adverse drug reactions (ADRs) in the treatment of patients with psychiatric disorders, may provide a key to the development of a strategy for personalized prevention and treatment of the considered complication of AP therapy for schizophrenia in real clinical practice. |
| first_indexed | 2024-03-10T08:59:03Z |
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| last_indexed | 2024-03-10T08:59:03Z |
| publishDate | 2021-07-01 |
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| series | Biomedicines |
| spelling | doaj.art-049781738574494c9ea1dc5d15b3deef2023-11-22T06:51:25ZengMDPI AGBiomedicines2227-90592021-07-019887910.3390/biomedicines9080879Candidate Genes Encoding Dopamine Receptors as Predictors of the Risk of Antipsychotic-Induced Parkinsonism and Tardive Dyskinesia in Schizophrenic PatientsElena E. Vaiman0Natalia A. Shnayder1Maxim A. Novitsky2Vera S. Dobrodeeva3Polina S. Goncharova4Elena N. Bochanova5Margarita R. Sapronova6Tatiana E. Popova7Alexey A. Tappakhov8Regina F. Nasyrova9Centre of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint-Petersburg, RussiaCentre of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint-Petersburg, RussiaCentre of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint-Petersburg, RussiaCentre of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint-Petersburg, RussiaCentre of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint-Petersburg, RussiaDepartment of Pharmacology and Pharmaceutical Consulting, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, RussiaDepartment of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, RussiaYakutsk Scientific Center for Complex Medical Problems, Department of Epidemiology of Chronic Non-Inflectional Diseases, 677018 Yakutsk, RussiaDepartment of Neurology and Psychiatry, Medical Institute, M.K. Ammosov North-Eastern Federal University, 677000 Yakutsk, RussiaCentre of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint-Petersburg, Russia(1) Introduction: Extrapyramidal disorders form the so-called extrapyramidal syndrome (EPS), which is characterized by the occurrence of motor disorders as a result of damage to the basal ganglia and the subcortical-thalamic connections. Often, this syndrome develops while taking medications, in particular antipsychotics (APs). (2) Purpose: To review studies of candidate genes encoding dopamine receptors as genetic predictors of development of AP-induced parkinsonism (AIP) and AP-induced tardive dyskinesia (AITD) in patients with schizophrenia. (3) Materials and Methods: A search was carried out for publications of PubMed, Web of Science, Springer, and e-Library databases by keywords and their combinations over the last 10 years. In addition, the review includes earlier publications of historical interest. Despite extensive searches of these commonly used databases and search terms, it cannot be ruled out that some publications were possibly missed. (4) Results: The review considers candidate genes encoding dopamine receptors involved in pharmacodynamics, including genes <i>DRD1</i>, <i>DRD2</i>, <i>DRD3</i>, and <i>DRD4</i>. We analyzed 18 genome-wide studies examining 37 genetic variations, including single nucleotide variants (SNVs)/polymorphisms of four candidate genes involved in the development of AIP and AITD in patients with schizophrenia. Among such a set of obtained results, only 14 positive associations were revealed: rs1799732 (141CIns/Del), rs1800497 (C/T), rs6275 (C/T), rs6275 (C/T) <i>DRD2</i>; rs167771 (G/A) <i>DRD3</i> with AIP and rs4532 (A/G) <i>DRD1</i>, rs6277 (C/T), rs6275 (C/T), rs1800497 (C/T), rs1079597 (A/G), rs1799732 (141CIns/Del), rs1045280 (C/G) <i>DRD2</i>, rs6280 (C/T), rs905568 (C/G) <i>DRD3</i> with AITD. However, at present, it should be recognized that there is no final or unique decision on the leading role of any particular SNVs/polymorphisms in the development of AIP and AITD. (5) Conclusion: Disclosure of genetic predictors of the development of AIP and AITD, as the most common neurological adverse drug reactions (ADRs) in the treatment of patients with psychiatric disorders, may provide a key to the development of a strategy for personalized prevention and treatment of the considered complication of AP therapy for schizophrenia in real clinical practice.https://www.mdpi.com/2227-9059/9/8/879extrapyramidal syndromeantipsychoticsadverse drug reactionantipsychotic-induced parkinsonismantipsychotic-induced tardive dyskinesiagenetics |
| spellingShingle | Elena E. Vaiman Natalia A. Shnayder Maxim A. Novitsky Vera S. Dobrodeeva Polina S. Goncharova Elena N. Bochanova Margarita R. Sapronova Tatiana E. Popova Alexey A. Tappakhov Regina F. Nasyrova Candidate Genes Encoding Dopamine Receptors as Predictors of the Risk of Antipsychotic-Induced Parkinsonism and Tardive Dyskinesia in Schizophrenic Patients Biomedicines extrapyramidal syndrome antipsychotics adverse drug reaction antipsychotic-induced parkinsonism antipsychotic-induced tardive dyskinesia genetics |
| title | Candidate Genes Encoding Dopamine Receptors as Predictors of the Risk of Antipsychotic-Induced Parkinsonism and Tardive Dyskinesia in Schizophrenic Patients |
| title_full | Candidate Genes Encoding Dopamine Receptors as Predictors of the Risk of Antipsychotic-Induced Parkinsonism and Tardive Dyskinesia in Schizophrenic Patients |
| title_fullStr | Candidate Genes Encoding Dopamine Receptors as Predictors of the Risk of Antipsychotic-Induced Parkinsonism and Tardive Dyskinesia in Schizophrenic Patients |
| title_full_unstemmed | Candidate Genes Encoding Dopamine Receptors as Predictors of the Risk of Antipsychotic-Induced Parkinsonism and Tardive Dyskinesia in Schizophrenic Patients |
| title_short | Candidate Genes Encoding Dopamine Receptors as Predictors of the Risk of Antipsychotic-Induced Parkinsonism and Tardive Dyskinesia in Schizophrenic Patients |
| title_sort | candidate genes encoding dopamine receptors as predictors of the risk of antipsychotic induced parkinsonism and tardive dyskinesia in schizophrenic patients |
| topic | extrapyramidal syndrome antipsychotics adverse drug reaction antipsychotic-induced parkinsonism antipsychotic-induced tardive dyskinesia genetics |
| url | https://www.mdpi.com/2227-9059/9/8/879 |
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