Myeloid-Derived Suppressor Cells Dampen Airway Inflammation Through Prostaglandin E2 Receptor 4

Myeloid-Derived Suppressor Cells Dampen Airway Inflammation Through Prostaglandin E2 Receptor 4

Emerging evidence suggests a mechanistic role for myeloid-derived suppressor cells (MDSCs) in lung diseases like asthma. Previously, we showed that adoptive transfer of MDSCs dampens lung inflammation in murine models of asthma through cyclooxygenase-2 and arginase-1 pathways. Here, we further disse...

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Bibliographic Details
Main Authors: Chiel van Geffen, Astrid Deißler, Sandra Beer-Hammer, Bernd Nürnberg, Rupert Handgretinger, Harald Renz, Dominik Hartl, Saeed Kolahian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
myeloid-derived suppressor cells
prostaglandin E2
E-prostanoid receptors
arginase-1
airway inflammation
asthma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.695933/full

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