The Impact of Obesity on Various Semen Parameters and Sex Hormones in Iranian Men with Infertility: A Cross-Sectional Study
Leila Maghsoumi-Norouzabad,1 Ahmad Zare Javid,2 Saleh Aiiashi,1 Seyed Ahmad Hosseini,3 Mohammadreza Dadfar,4 Hadi Bazyar,1 Maryam Dastoorpur5 1Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Department of Nutrition, School of Allied Medical Sciences, Ahvaz...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-09-01
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| Series: | Research and Reports in Urology |
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| Online Access: | https://www.dovepress.com/the-impact-of-obesity-on-various-semen-parameters-and-sex-hormones-in--peer-reviewed-article-RRU |
| _version_ | 1811291732769243136 |
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| author | Maghsoumi-Norouzabad L Zare Javid A Aiiashi S Hosseini SA Dadfar M Bazyar H Dastoorpur M |
| author_facet | Maghsoumi-Norouzabad L Zare Javid A Aiiashi S Hosseini SA Dadfar M Bazyar H Dastoorpur M |
| author_sort | Maghsoumi-Norouzabad L |
| collection | DOAJ |
| description | Leila Maghsoumi-Norouzabad,1 Ahmad Zare Javid,2 Saleh Aiiashi,1 Seyed Ahmad Hosseini,3 Mohammadreza Dadfar,4 Hadi Bazyar,1 Maryam Dastoorpur5 1Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 3Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 4Department of Urology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 5Department of Biostatistics and Epidemiology, Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranCorrespondence: Saleh AiiashiDepartment of Biochemistry, Ahvaz Jundishapur University of Medical Sciences, Golestan Street, Ahvaz, IranEmail s.aiiashi65@gmail.comObjective: The aim of this study was to examine the correlations between body mass index (BMI) and waist circumference (WC) and semen parameters (semen volume, sperm count, motility, and morphology) and sex hormones in Iranian men with infertility.Materials and Methods: In this cross-sectional study, a total of 119 male patients who had lived as a partner in an infertile couple for at least 1 year, after regular unprotected sexual intercourse in their married life were investigated. BMI and WC were assessed, and a morning blood sample was taken assessing serum levels of testosterone (T), sex hormone-binding globulin (SHBG), prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and leptin. Semen-analysis parameters were also measured.Results: Based on BMI and WC, the sperm count, total motility and progressive sperm were significantly lower in overweight and obese infertile males compared to that in normal weight infertile males and those with WC< 102 cm. In addition, the fraction of sperm with abnormal morphology was significantly higher in infertile men with WC> 102 cm compared to that in those with WC< 102 cm. Moreover serum levels of LH, FSH, and leptin were significantly higher in overweight and obese infertile males compared to that in normal weight infertile males and those with WC< 102 cm. Moreover serum level of E2 was significantly higher in obese infertile males compared to the normal weight infertile males and in those with WC> 102 cm compared to the WC< 102 cm. Furthermore, serum level of T was significantly lower in obese infertile males compared to the overweight infertile males and in those with WC> 102 cm compared to the WC< 102 cm. The mean of T/E2 ratio also was significantly lower in obese infertile males vs overweight and normal weight infertile males and in those with WC> 102 cm compared to the WC< 102 cm.Conclusion: We concluded that overweight and obesity in infertile men compared to those with normal weight may worsen the infertility situation.Keywords: male infertility, obesity, semen parameters, sex hormones |
| first_indexed | 2024-04-13T04:34:42Z |
| format | Article |
| id | doaj.art-0498111902b94f289c7f3c37593e3873 |
| institution | Directory Open Access Journal |
| issn | 2253-2447 |
| language | English |
| last_indexed | 2024-04-13T04:34:42Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Research and Reports in Urology |
| spelling | doaj.art-0498111902b94f289c7f3c37593e38732022-12-22T03:02:13ZengDove Medical PressResearch and Reports in Urology2253-24472020-09-01Volume 1235736556728The Impact of Obesity on Various Semen Parameters and Sex Hormones in Iranian Men with Infertility: A Cross-Sectional StudyMaghsoumi-Norouzabad LZare Javid AAiiashi SHosseini SADadfar MBazyar HDastoorpur MLeila Maghsoumi-Norouzabad,1 Ahmad Zare Javid,2 Saleh Aiiashi,1 Seyed Ahmad Hosseini,3 Mohammadreza Dadfar,4 Hadi Bazyar,1 Maryam Dastoorpur5 1Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 3Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 4Department of Urology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 5Department of Biostatistics and Epidemiology, Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranCorrespondence: Saleh AiiashiDepartment of Biochemistry, Ahvaz Jundishapur University of Medical Sciences, Golestan Street, Ahvaz, IranEmail s.aiiashi65@gmail.comObjective: The aim of this study was to examine the correlations between body mass index (BMI) and waist circumference (WC) and semen parameters (semen volume, sperm count, motility, and morphology) and sex hormones in Iranian men with infertility.Materials and Methods: In this cross-sectional study, a total of 119 male patients who had lived as a partner in an infertile couple for at least 1 year, after regular unprotected sexual intercourse in their married life were investigated. BMI and WC were assessed, and a morning blood sample was taken assessing serum levels of testosterone (T), sex hormone-binding globulin (SHBG), prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and leptin. Semen-analysis parameters were also measured.Results: Based on BMI and WC, the sperm count, total motility and progressive sperm were significantly lower in overweight and obese infertile males compared to that in normal weight infertile males and those with WC< 102 cm. In addition, the fraction of sperm with abnormal morphology was significantly higher in infertile men with WC> 102 cm compared to that in those with WC< 102 cm. Moreover serum levels of LH, FSH, and leptin were significantly higher in overweight and obese infertile males compared to that in normal weight infertile males and those with WC< 102 cm. Moreover serum level of E2 was significantly higher in obese infertile males compared to the normal weight infertile males and in those with WC> 102 cm compared to the WC< 102 cm. Furthermore, serum level of T was significantly lower in obese infertile males compared to the overweight infertile males and in those with WC> 102 cm compared to the WC< 102 cm. The mean of T/E2 ratio also was significantly lower in obese infertile males vs overweight and normal weight infertile males and in those with WC> 102 cm compared to the WC< 102 cm.Conclusion: We concluded that overweight and obesity in infertile men compared to those with normal weight may worsen the infertility situation.Keywords: male infertility, obesity, semen parameters, sex hormoneshttps://www.dovepress.com/the-impact-of-obesity-on-various-semen-parameters-and-sex-hormones-in--peer-reviewed-article-RRUmale infertilityobesitysemen parameterssex hormones |
| spellingShingle | Maghsoumi-Norouzabad L Zare Javid A Aiiashi S Hosseini SA Dadfar M Bazyar H Dastoorpur M The Impact of Obesity on Various Semen Parameters and Sex Hormones in Iranian Men with Infertility: A Cross-Sectional Study Research and Reports in Urology male infertility obesity semen parameters sex hormones |
| title | The Impact of Obesity on Various Semen Parameters and Sex Hormones in Iranian Men with Infertility: A Cross-Sectional Study |
| title_full | The Impact of Obesity on Various Semen Parameters and Sex Hormones in Iranian Men with Infertility: A Cross-Sectional Study |
| title_fullStr | The Impact of Obesity on Various Semen Parameters and Sex Hormones in Iranian Men with Infertility: A Cross-Sectional Study |
| title_full_unstemmed | The Impact of Obesity on Various Semen Parameters and Sex Hormones in Iranian Men with Infertility: A Cross-Sectional Study |
| title_short | The Impact of Obesity on Various Semen Parameters and Sex Hormones in Iranian Men with Infertility: A Cross-Sectional Study |
| title_sort | impact of obesity on various semen parameters and sex hormones in iranian men with infertility a cross sectional study |
| topic | male infertility obesity semen parameters sex hormones |
| url | https://www.dovepress.com/the-impact-of-obesity-on-various-semen-parameters-and-sex-hormones-in--peer-reviewed-article-RRU |
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