Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia
Objective: Cancer, one of the principal causes of death, is a global social health problem. Autoantibodies developed against the organism's self-antigens are detected in the sera of subjects with cancer. In recent years carbonic anhydrase (CA) I and II autoantibodies have been shown in some au...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2017-11-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-44442 |
| _version_ | 1797909156327325696 |
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| author | Ahmet Menteşe Nergiz Erkut Selim Demir Serap Özer Yaman Aysegül Sümer Seniz Doğramacı Ahmet Alver Mehmet Sönmez |
| author_facet | Ahmet Menteşe Nergiz Erkut Selim Demir Serap Özer Yaman Aysegül Sümer Seniz Doğramacı Ahmet Alver Mehmet Sönmez |
| author_sort | Ahmet Menteşe |
| collection | DOAJ |
| description | Objective: Cancer, one of the principal causes of death, is a global social health problem. Autoantibodies developed against the organism's self-antigens are detected in the sera of subjects with cancer. In recent years carbonic anhydrase (CA) I and II autoantibodies have been shown in some autoimmune diseases and carcinomas, but the mechanisms underlying this immune response have not yet been explained. The aim of this study was to evaluate CA I and II autoantibodies in patients with acute myeloid leukemia (AML) and to provide a novel perspective regarding the autoimmune basis of the disease. Materials and Methods: Anti-CA I and II antibody levels were investigated using ELISA in serum samples from 30 patients with AML and 30 healthy peers. Results: Anti-CA I and II antibody titers in the AML group were significantly higher compared with the control group (p=0.0001 and 0.018, respectively). A strong positive correlation was also determined between titers of anti-CA I and II antibodies (r=0.613, p=0.0001). Conclusion: Our results suggest that these autoantibodies may be involved in the pathogenesis of AML. More extensive studies are now needed to reveal the entire mechanism. |
| first_indexed | 2024-04-10T11:03:58Z |
| format | Article |
| id | doaj.art-049d75eab83a4a9199cdff184ca7e073 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:03:58Z |
| publishDate | 2017-11-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-049d75eab83a4a9199cdff184ca7e0732023-02-15T16:19:31ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632017-11-0134430731310.4274/tjh.2016.0341TJH-44442Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid LeukemiaAhmet Menteşe0Nergiz Erkut1Selim Demir2Serap Özer Yaman3Aysegül Sümer4Seniz Doğramacı5Ahmet Alver6Mehmet Sönmez7Karadeniz Technical University Vocational School of Health Sciences, Program of Medical Laboratory Techniques, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Hematology, Trabzon, TurkeyKaradeniz Technical University Faculty of Health Sciences, Department of Nutrition and Dietetics, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Medical Biochemistry, Trabzon, TurkeyRecep Tayyip Erdoğan University Faculty of Health Services, Department of Nursing, Rize, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Medical Biochemistry, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Medical Biochemistry, Trabzon, Turkey; Recep Tayyip Erdoğan University Faculty of Medicine, Department of Medical Biochemistry, Rize, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Hematology, Trabzon, TurkeyObjective: Cancer, one of the principal causes of death, is a global social health problem. Autoantibodies developed against the organism's self-antigens are detected in the sera of subjects with cancer. In recent years carbonic anhydrase (CA) I and II autoantibodies have been shown in some autoimmune diseases and carcinomas, but the mechanisms underlying this immune response have not yet been explained. The aim of this study was to evaluate CA I and II autoantibodies in patients with acute myeloid leukemia (AML) and to provide a novel perspective regarding the autoimmune basis of the disease. Materials and Methods: Anti-CA I and II antibody levels were investigated using ELISA in serum samples from 30 patients with AML and 30 healthy peers. Results: Anti-CA I and II antibody titers in the AML group were significantly higher compared with the control group (p=0.0001 and 0.018, respectively). A strong positive correlation was also determined between titers of anti-CA I and II antibodies (r=0.613, p=0.0001). Conclusion: Our results suggest that these autoantibodies may be involved in the pathogenesis of AML. More extensive studies are now needed to reveal the entire mechanism.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-44442acute myeloid leukemiaautoantibodycancercarbonic anhydrase |
| spellingShingle | Ahmet Menteşe Nergiz Erkut Selim Demir Serap Özer Yaman Aysegül Sümer Seniz Doğramacı Ahmet Alver Mehmet Sönmez Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia Turkish Journal of Hematology acute myeloid leukemia autoantibody cancer carbonic anhydrase |
| title | Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia |
| title_full | Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia |
| title_fullStr | Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia |
| title_full_unstemmed | Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia |
| title_short | Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia |
| title_sort | autoantibodies against carbonic anhydrase i and ii in patients with acute myeloid leukemia |
| topic | acute myeloid leukemia autoantibody cancer carbonic anhydrase |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-44442 |
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