Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene
Introduction: The development of left ventricular remodelling after acute myocardial infarction is a predictor of heart failure and mortality. The purpose of the present study was to assess whether the polymorphism of angiotensinogen ( AGT ) gene with threonine (T) instead of methionine (M) at amino...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2014-09-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320312471228 |
| _version_ | 1797285099367038976 |
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| author | Diana Zaliaduonyte-Peksiene Sandrita Simonyte Vaiva Lesauskaite Jolanta Vaskelyte Olivija Gustiene Vaida Mizariene Renaldas Jurkevicius Giedre Jariene Abdonas Tamosiunas Remigijus Zaliunas |
| author_facet | Diana Zaliaduonyte-Peksiene Sandrita Simonyte Vaiva Lesauskaite Jolanta Vaskelyte Olivija Gustiene Vaida Mizariene Renaldas Jurkevicius Giedre Jariene Abdonas Tamosiunas Remigijus Zaliunas |
| author_sort | Diana Zaliaduonyte-Peksiene |
| collection | DOAJ |
| description | Introduction: The development of left ventricular remodelling after acute myocardial infarction is a predictor of heart failure and mortality. The purpose of the present study was to assess whether the polymorphism of angiotensinogen ( AGT ) gene with threonine (T) instead of methionine (M) at amino acid 235 in exon 2 ( M235T ) had effects on cardiac remodelling after acute myocardial infarction. Methods: One hundred and forty-one patients (mean age 56.4±11.1 years) with a first acute myocardial infarction were enrolled. Within 24–72 hours of the onset of the symptoms and at a four month period two-dimensional echocardiography was performed. Remodelling was defined as a 20% increase from the baseline in left ventricular end-diastolic volume. The genotypes of the study group were compared with the reference group ( n =1010) genotypes. AGT M235T polymorphism was determined using polymerase chain reaction amplification. Results: At follow-up, 49 patients (34.7%) were classified as having left ventricular remodelling. Anterior localization of the infarct ( p =0.008), leucocyte count at admission ( p =0.040), global left ventricular longitudinal strain ( p =0.021) and MM genotype of AGT ( p =0.024) were independent predictors of ventricular remodelling after myocardial infarction. Conclusions: Anterior wall infarction, increased leucocyte count, decreased longitudinal strain of left ventricular and polymorphism of AGT M235T may predict remodelling after myocardial infarction. |
| first_indexed | 2024-03-07T17:57:21Z |
| format | Article |
| id | doaj.art-04a2b425377b43c09240c9380909bdbd |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:57:21Z |
| publishDate | 2014-09-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-04a2b425377b43c09240c9380909bdbd2024-03-02T11:36:04ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762014-09-011510.1177/1470320312471228Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen geneDiana Zaliaduonyte-Peksiene0Sandrita Simonyte1Vaiva Lesauskaite2Jolanta Vaskelyte3Olivija Gustiene4Vaida Mizariene5Renaldas Jurkevicius6Giedre Jariene7Abdonas Tamosiunas8Remigijus Zaliunas9Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LithuaniaInstitute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LithuaniaInstitute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LithuaniaInstitute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LithuaniaDepartment of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LithuaniaDepartment of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LithuaniaDepartment of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LithuaniaInstitute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LithuaniaInstitute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LithuaniaDepartment of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LithuaniaIntroduction: The development of left ventricular remodelling after acute myocardial infarction is a predictor of heart failure and mortality. The purpose of the present study was to assess whether the polymorphism of angiotensinogen ( AGT ) gene with threonine (T) instead of methionine (M) at amino acid 235 in exon 2 ( M235T ) had effects on cardiac remodelling after acute myocardial infarction. Methods: One hundred and forty-one patients (mean age 56.4±11.1 years) with a first acute myocardial infarction were enrolled. Within 24–72 hours of the onset of the symptoms and at a four month period two-dimensional echocardiography was performed. Remodelling was defined as a 20% increase from the baseline in left ventricular end-diastolic volume. The genotypes of the study group were compared with the reference group ( n =1010) genotypes. AGT M235T polymorphism was determined using polymerase chain reaction amplification. Results: At follow-up, 49 patients (34.7%) were classified as having left ventricular remodelling. Anterior localization of the infarct ( p =0.008), leucocyte count at admission ( p =0.040), global left ventricular longitudinal strain ( p =0.021) and MM genotype of AGT ( p =0.024) were independent predictors of ventricular remodelling after myocardial infarction. Conclusions: Anterior wall infarction, increased leucocyte count, decreased longitudinal strain of left ventricular and polymorphism of AGT M235T may predict remodelling after myocardial infarction.https://doi.org/10.1177/1470320312471228 |
| spellingShingle | Diana Zaliaduonyte-Peksiene Sandrita Simonyte Vaiva Lesauskaite Jolanta Vaskelyte Olivija Gustiene Vaida Mizariene Renaldas Jurkevicius Giedre Jariene Abdonas Tamosiunas Remigijus Zaliunas Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene Journal of the Renin-Angiotensin-Aldosterone System |
| title | Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene |
| title_full | Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene |
| title_fullStr | Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene |
| title_full_unstemmed | Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene |
| title_short | Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene |
| title_sort | left ventricular remodelling after acute myocardial infarction impact of clinical echocardiographic parameters and polymorphism of angiotensinogen gene |
| url | https://doi.org/10.1177/1470320312471228 |
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