Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study
Abstract Background Dementia is an increasing public health threat worldwide. The pathogenesis of dementia has not been fully elucidated yet. Inflammatory processes are hypothesized to play an important role as a driver for cognitive decline but the origin of inflammation is not clear. We hypothesiz...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12877-020-01644-2 |
| _version_ | 1819020509132619776 |
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| author | Vanessa Stadlbauer Lara Engertsberger Irina Komarova Nicole Feldbacher Bettina Leber Gerald Pichler Nicole Fink Monika Scarpatetti Walter Schippinger Reinhold Schmidt Angela Horvath |
| author_facet | Vanessa Stadlbauer Lara Engertsberger Irina Komarova Nicole Feldbacher Bettina Leber Gerald Pichler Nicole Fink Monika Scarpatetti Walter Schippinger Reinhold Schmidt Angela Horvath |
| author_sort | Vanessa Stadlbauer |
| collection | DOAJ |
| description | Abstract Background Dementia is an increasing public health threat worldwide. The pathogenesis of dementia has not been fully elucidated yet. Inflammatory processes are hypothesized to play an important role as a driver for cognitive decline but the origin of inflammation is not clear. We hypothesize that disturbances in gut microbiome composition, gut barrier dysfunction, bacterial translocation and resulting inflammation are associated with cognitive dysfunction in dementia. Methods To test this hypothesis, a cohort of 23 patients with dementia and 18 age and sex matched controls without cognitive impairments were studied. Gut microbiome composition, gut barrier dysfunction, bacterial translocation and inflammation were assessed from stool and serum samples. Malnutrition was assessed by Mini Nutritional Assessment Short Form (MNA-SF), detailed information on drug use was collected. Microbiome composition was assessed by 16S rRNA sequencing, QIIME 2 and Calypso 7.14 tools. Results Dementia was associated with dysbiosis characterized by differences in beta diversity and changes in taxonomic composition. Gut permeability was increased as evidenced by increased serum diamine oxidase (DAO) levels and systemic inflammation was confirmed by increased soluble cluster of differentiation 14 levels (sCD14). BMI and statin use had the strongest impact on microbiome composition. Conclusion Dementia is associated with changes in gut microbiome composition and increased biomarkers of gut permeability and inflammation. Lachnospiraceae NK4A136 group as potential butyrate producer was reduced in dementia. Malnutrition and drug intake were factors, that impact on microbiome composition. Increasing butyrate producing bacteria and targeting malnutrition may be promising therapeutic targets in dementia. Trial registration NCT03167983 . |
| first_indexed | 2024-12-21T03:52:20Z |
| format | Article |
| id | doaj.art-04a3c2f9852d4a54a5e67cb54a379cd2 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-21T03:52:20Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-04a3c2f9852d4a54a5e67cb54a379cd22022-12-21T19:16:55ZengBMCBMC Geriatrics1471-23182020-07-0120111310.1186/s12877-020-01644-2Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot studyVanessa Stadlbauer0Lara Engertsberger1Irina Komarova2Nicole Feldbacher3Bettina Leber4Gerald Pichler5Nicole Fink6Monika Scarpatetti7Walter Schippinger8Reinhold Schmidt9Angela Horvath10Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of GrazDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of GrazDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of GrazDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of GrazDepartment of Surgery, Division of Transplantation Surgery, Medical University of GrazDepartment of Neurology, Geriatric Health Centers Graz, Albert Schweitzer HospitalDepartment of Neurology, Geriatric Health Centers Graz, Albert Schweitzer HospitalDepartment of Neurology, Geriatric Health Centers Graz, Albert Schweitzer HospitalDepartment of Neurology, Geriatric Health Centers Graz, Albert Schweitzer HospitalClinical Division of Neurogeriatrics, Department of Neurology, Medical University of GrazDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of GrazAbstract Background Dementia is an increasing public health threat worldwide. The pathogenesis of dementia has not been fully elucidated yet. Inflammatory processes are hypothesized to play an important role as a driver for cognitive decline but the origin of inflammation is not clear. We hypothesize that disturbances in gut microbiome composition, gut barrier dysfunction, bacterial translocation and resulting inflammation are associated with cognitive dysfunction in dementia. Methods To test this hypothesis, a cohort of 23 patients with dementia and 18 age and sex matched controls without cognitive impairments were studied. Gut microbiome composition, gut barrier dysfunction, bacterial translocation and inflammation were assessed from stool and serum samples. Malnutrition was assessed by Mini Nutritional Assessment Short Form (MNA-SF), detailed information on drug use was collected. Microbiome composition was assessed by 16S rRNA sequencing, QIIME 2 and Calypso 7.14 tools. Results Dementia was associated with dysbiosis characterized by differences in beta diversity and changes in taxonomic composition. Gut permeability was increased as evidenced by increased serum diamine oxidase (DAO) levels and systemic inflammation was confirmed by increased soluble cluster of differentiation 14 levels (sCD14). BMI and statin use had the strongest impact on microbiome composition. Conclusion Dementia is associated with changes in gut microbiome composition and increased biomarkers of gut permeability and inflammation. Lachnospiraceae NK4A136 group as potential butyrate producer was reduced in dementia. Malnutrition and drug intake were factors, that impact on microbiome composition. Increasing butyrate producing bacteria and targeting malnutrition may be promising therapeutic targets in dementia. Trial registration NCT03167983 .http://link.springer.com/article/10.1186/s12877-020-01644-2MicrobiomeDiversityGut barrierInflammationCognitive functionButyrate producer |
| spellingShingle | Vanessa Stadlbauer Lara Engertsberger Irina Komarova Nicole Feldbacher Bettina Leber Gerald Pichler Nicole Fink Monika Scarpatetti Walter Schippinger Reinhold Schmidt Angela Horvath Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study BMC Geriatrics Microbiome Diversity Gut barrier Inflammation Cognitive function Butyrate producer |
| title | Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study |
| title_full | Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study |
| title_fullStr | Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study |
| title_full_unstemmed | Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study |
| title_short | Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study |
| title_sort | dysbiosis gut barrier dysfunction and inflammation in dementia a pilot study |
| topic | Microbiome Diversity Gut barrier Inflammation Cognitive function Butyrate producer |
| url | http://link.springer.com/article/10.1186/s12877-020-01644-2 |
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