Influence of Gender on Radiosensitivity during Radiochemotherapy of Advanced Rectal Cancer
Gender is increasingly recognized as an important factor in medicine, although it has long been neglected in medical research in many areas. We have studied the influence of gender in advanced rectal cancer with a special focus on radiosensitivity. For this purpose, we studied a cohort of 495 men (8...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/1/148 |
| _version_ | 1797499410981060608 |
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| author | Barbara Schuster Markus Hecht Manfred Schmidt Marlen Haderlein Tina Jost Maike Büttner-Herold Klaus Weber Axel Denz Robert Grützmann Arndt Hartmann Hans Geinitz Rainer Fietkau Luitpold V. Distel |
| author_facet | Barbara Schuster Markus Hecht Manfred Schmidt Marlen Haderlein Tina Jost Maike Büttner-Herold Klaus Weber Axel Denz Robert Grützmann Arndt Hartmann Hans Geinitz Rainer Fietkau Luitpold V. Distel |
| author_sort | Barbara Schuster |
| collection | DOAJ |
| description | Gender is increasingly recognized as an important factor in medicine, although it has long been neglected in medical research in many areas. We have studied the influence of gender in advanced rectal cancer with a special focus on radiosensitivity. For this purpose, we studied a cohort of 495 men (84.1% ≥ T3, 63.6% N1, 17.6%, M1) and 215 women (84.2% ≥ T3, 56.7% N1, 22.8%, M1) who all suffered from advanced rectal cancer and were treated with radiochemotherapy. The energy deposited, DNA double-strand break (dsb) repair, occurrence of chromosomal aberrations, duration of therapy, tumor regression and tumor-infiltrating lymphocytes, laboratory parameters, quality of life and survival were assessed. The residual DNA dsb damage 24 h after irradiation in lymphocytes was identical in both sexes. Furthermore, chromosomal aberrations accurately reflecting radiosensitivity, were similar in both sexes. There were no gender-dependent differences in tumor regression, tumor-infiltrating lymphocytes and outcome indicating no differences in the radiosensitivity of cancer cells. The irradiated tumor volume in women was slightly lower than in men, related to body weight, no difference was observed. However, when the total energy deposited was calculated and related to the body weight, women were exposed to higher amounts of ionizing radiation. During radiochemotherapy, decreases in blood lymphocyte counts and albumin and several quality-of-life parameters such as nausea and vomiting, loss of appetite, and diarrhea were significantly worse in women. There is no difference in radiation sensitivity between men and women in both normal tissue and tumors. During radiochemotherapy, the quality of life deteriorates more in women than in men. However, women also recover quickly and there are no long-term differences in quality of life. |
| first_indexed | 2024-03-10T03:46:58Z |
| format | Article |
| id | doaj.art-04a5104db7ee45a1a1fb2d71e24977e6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:46:58Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-04a5104db7ee45a1a1fb2d71e24977e62023-11-23T11:16:50ZengMDPI AGCancers2072-66942021-12-0114114810.3390/cancers14010148Influence of Gender on Radiosensitivity during Radiochemotherapy of Advanced Rectal CancerBarbara Schuster0Markus Hecht1Manfred Schmidt2Marlen Haderlein3Tina Jost4Maike Büttner-Herold5Klaus Weber6Axel Denz7Robert Grützmann8Arndt Hartmann9Hans Geinitz10Rainer Fietkau11Luitpold V. Distel12Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyDepartment of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyDepartment of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyDepartment of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyDepartment of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyComprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyComprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyComprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyComprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyComprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyDepartment of Radiation Oncology, Ordensklinikum Linz, Barmherzige Schwestern, 4010 Linz, AustriaDepartment of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyDepartment of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyGender is increasingly recognized as an important factor in medicine, although it has long been neglected in medical research in many areas. We have studied the influence of gender in advanced rectal cancer with a special focus on radiosensitivity. For this purpose, we studied a cohort of 495 men (84.1% ≥ T3, 63.6% N1, 17.6%, M1) and 215 women (84.2% ≥ T3, 56.7% N1, 22.8%, M1) who all suffered from advanced rectal cancer and were treated with radiochemotherapy. The energy deposited, DNA double-strand break (dsb) repair, occurrence of chromosomal aberrations, duration of therapy, tumor regression and tumor-infiltrating lymphocytes, laboratory parameters, quality of life and survival were assessed. The residual DNA dsb damage 24 h after irradiation in lymphocytes was identical in both sexes. Furthermore, chromosomal aberrations accurately reflecting radiosensitivity, were similar in both sexes. There were no gender-dependent differences in tumor regression, tumor-infiltrating lymphocytes and outcome indicating no differences in the radiosensitivity of cancer cells. The irradiated tumor volume in women was slightly lower than in men, related to body weight, no difference was observed. However, when the total energy deposited was calculated and related to the body weight, women were exposed to higher amounts of ionizing radiation. During radiochemotherapy, decreases in blood lymphocyte counts and albumin and several quality-of-life parameters such as nausea and vomiting, loss of appetite, and diarrhea were significantly worse in women. There is no difference in radiation sensitivity between men and women in both normal tissue and tumors. During radiochemotherapy, the quality of life deteriorates more in women than in men. However, women also recover quickly and there are no long-term differences in quality of life.https://www.mdpi.com/2072-6694/14/1/148genderrectal cancerradiochemotherapyradiosensitivityDNA double-strand breaksradiosensitivity |
| spellingShingle | Barbara Schuster Markus Hecht Manfred Schmidt Marlen Haderlein Tina Jost Maike Büttner-Herold Klaus Weber Axel Denz Robert Grützmann Arndt Hartmann Hans Geinitz Rainer Fietkau Luitpold V. Distel Influence of Gender on Radiosensitivity during Radiochemotherapy of Advanced Rectal Cancer Cancers gender rectal cancer radiochemotherapy radiosensitivity DNA double-strand breaks radiosensitivity |
| title | Influence of Gender on Radiosensitivity during Radiochemotherapy of Advanced Rectal Cancer |
| title_full | Influence of Gender on Radiosensitivity during Radiochemotherapy of Advanced Rectal Cancer |
| title_fullStr | Influence of Gender on Radiosensitivity during Radiochemotherapy of Advanced Rectal Cancer |
| title_full_unstemmed | Influence of Gender on Radiosensitivity during Radiochemotherapy of Advanced Rectal Cancer |
| title_short | Influence of Gender on Radiosensitivity during Radiochemotherapy of Advanced Rectal Cancer |
| title_sort | influence of gender on radiosensitivity during radiochemotherapy of advanced rectal cancer |
| topic | gender rectal cancer radiochemotherapy radiosensitivity DNA double-strand breaks radiosensitivity |
| url | https://www.mdpi.com/2072-6694/14/1/148 |
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