Radical hydrodifluoromethylation of unsaturated C−C bonds via an electroreductively triggered two-pronged approach
The installation of difluoromethylene groups into bio-relevant molecules allows access to important scaffolds, but existing methods to do so often rely on oxidative chemical species that can hamper reactivity. Here, radical hydrodifluoromethylation with a wide range of unsaturated C–C bonds is achie...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
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Nature Portfolio
2022-08-01
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Series: | Communications Chemistry |
Online Access: | https://doi.org/10.1038/s42004-022-00697-1 |
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author | Seonyoung Kim Keon Ha Hwang Hyeong Gyu Park Jaesung Kwak Hyuk Lee Hyunwoo Kim |
author_facet | Seonyoung Kim Keon Ha Hwang Hyeong Gyu Park Jaesung Kwak Hyuk Lee Hyunwoo Kim |
author_sort | Seonyoung Kim |
collection | DOAJ |
description | The installation of difluoromethylene groups into bio-relevant molecules allows access to important scaffolds, but existing methods to do so often rely on oxidative chemical species that can hamper reactivity. Here, radical hydrodifluoromethylation with a wide range of unsaturated C–C bonds is achieved via an electroreductive two-pronged approach, granting access to a variety of difluoromethylated organic molecules. |
first_indexed | 2024-04-13T13:05:51Z |
format | Article |
id | doaj.art-04a550507aa94d2c83afcee6d6b3edac |
institution | Directory Open Access Journal |
issn | 2399-3669 |
language | English |
last_indexed | 2024-04-13T13:05:51Z |
publishDate | 2022-08-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Communications Chemistry |
spelling | doaj.art-04a550507aa94d2c83afcee6d6b3edac2022-12-22T02:45:47ZengNature PortfolioCommunications Chemistry2399-36692022-08-01511910.1038/s42004-022-00697-1Radical hydrodifluoromethylation of unsaturated C−C bonds via an electroreductively triggered two-pronged approachSeonyoung Kim0Keon Ha Hwang1Hyeong Gyu Park2Jaesung Kwak3Hyuk Lee4Hyunwoo Kim5Department of Chemistry and Nanoscience, Ewha Womans UniversityInfectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT)Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT)Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT)Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT)Department of Chemistry, Pohang University of Science and Technology (POSTECH)The installation of difluoromethylene groups into bio-relevant molecules allows access to important scaffolds, but existing methods to do so often rely on oxidative chemical species that can hamper reactivity. Here, radical hydrodifluoromethylation with a wide range of unsaturated C–C bonds is achieved via an electroreductive two-pronged approach, granting access to a variety of difluoromethylated organic molecules.https://doi.org/10.1038/s42004-022-00697-1 |
spellingShingle | Seonyoung Kim Keon Ha Hwang Hyeong Gyu Park Jaesung Kwak Hyuk Lee Hyunwoo Kim Radical hydrodifluoromethylation of unsaturated C−C bonds via an electroreductively triggered two-pronged approach Communications Chemistry |
title | Radical hydrodifluoromethylation of unsaturated C−C bonds via an electroreductively triggered two-pronged approach |
title_full | Radical hydrodifluoromethylation of unsaturated C−C bonds via an electroreductively triggered two-pronged approach |
title_fullStr | Radical hydrodifluoromethylation of unsaturated C−C bonds via an electroreductively triggered two-pronged approach |
title_full_unstemmed | Radical hydrodifluoromethylation of unsaturated C−C bonds via an electroreductively triggered two-pronged approach |
title_short | Radical hydrodifluoromethylation of unsaturated C−C bonds via an electroreductively triggered two-pronged approach |
title_sort | radical hydrodifluoromethylation of unsaturated c c bonds via an electroreductively triggered two pronged approach |
url | https://doi.org/10.1038/s42004-022-00697-1 |
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