Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity
Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives’ applicative pot...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/22/12139 |
| _version_ | 1797510035985661952 |
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| author | Corina Popovici Cristina-Maria Pavel Valeriu Sunel Corina Cheptea Dan Gheorghe Dimitriu Dana Ortansa Dorohoi Diana David Valentina Closca Marcel Popa |
| author_facet | Corina Popovici Cristina-Maria Pavel Valeriu Sunel Corina Cheptea Dan Gheorghe Dimitriu Dana Ortansa Dorohoi Diana David Valentina Closca Marcel Popa |
| author_sort | Corina Popovici |
| collection | DOAJ |
| description | Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives’ applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and <sup>1</sup>H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against <i>Mycobacterium tuberculosis</i>. |
| first_indexed | 2024-03-10T05:26:13Z |
| format | Article |
| id | doaj.art-04a6f0ce30ec47b2b9bb10283d1c308c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:26:13Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-04a6f0ce30ec47b2b9bb10283d1c308c2023-11-22T23:37:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122221213910.3390/ijms222212139Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic ActivityCorina Popovici0Cristina-Maria Pavel1Valeriu Sunel2Corina Cheptea3Dan Gheorghe Dimitriu4Dana Ortansa Dorohoi5Diana David6Valentina Closca7Marcel Popa8Faculty of Chemistry, Alexandru Ioan Cuza University, 11 Carol I Blvd., 700506 Iasi, RomaniaFaculty of Physics, Alexandru Ioan Cuza University, 11 Carol I Blvd., 700506 Iasi, RomaniaFaculty of Chemistry, Alexandru Ioan Cuza University, 11 Carol I Blvd., 700506 Iasi, RomaniaDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, “Grigore T. Popa” University of Medicine and Pharmacy, 9-13 M. Kogalniceanu Str., 700454 Iasi, RomaniaFaculty of Physics, Alexandru Ioan Cuza University, 11 Carol I Blvd., 700506 Iasi, RomaniaFaculty of Physics, Alexandru Ioan Cuza University, 11 Carol I Blvd., 700506 Iasi, RomaniaWarwick Medical School, University of Warwick, Coventry CV4 7AL, UKFaculty of Physics, Alexandru Ioan Cuza University, 11 Carol I Blvd., 700506 Iasi, RomaniaDepartment of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Sachi” Technical University, 73 Professor Dimitrie Mangeron Blvd., 700050 Iasi, RomaniaOriginal results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives’ applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and <sup>1</sup>H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against <i>Mycobacterium tuberculosis</i>.https://www.mdpi.com/1422-0067/22/22/121392-mercapto-benzimidazolesulfonic derivativesheterocyclic thiosemicarbazidestuberculostatic activity |
| spellingShingle | Corina Popovici Cristina-Maria Pavel Valeriu Sunel Corina Cheptea Dan Gheorghe Dimitriu Dana Ortansa Dorohoi Diana David Valentina Closca Marcel Popa Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity International Journal of Molecular Sciences 2-mercapto-benzimidazole sulfonic derivatives heterocyclic thiosemicarbazides tuberculostatic activity |
| title | Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity |
| title_full | Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity |
| title_fullStr | Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity |
| title_full_unstemmed | Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity |
| title_short | Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity |
| title_sort | optimized synthesis of new thiosemicarbazide derivatives with tuberculostatic activity |
| topic | 2-mercapto-benzimidazole sulfonic derivatives heterocyclic thiosemicarbazides tuberculostatic activity |
| url | https://www.mdpi.com/1422-0067/22/22/12139 |
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