Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration
Magnesium (Mg) is involved in the regulation of metabolism and in the maintenance of the homeostasis of all the tissues, including the brain, where it harmonizes nerve signal transmission and preserves the integrity of the blood–brain barrier. Mg deficiency contributes to systemic low-grade inflamma...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/1/223 |
| _version_ | 1797406750445404160 |
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| author | Jeanette A. M. Maier Laura Locatelli Giorgia Fedele Alessandra Cazzaniga André Mazur |
| author_facet | Jeanette A. M. Maier Laura Locatelli Giorgia Fedele Alessandra Cazzaniga André Mazur |
| author_sort | Jeanette A. M. Maier |
| collection | DOAJ |
| description | Magnesium (Mg) is involved in the regulation of metabolism and in the maintenance of the homeostasis of all the tissues, including the brain, where it harmonizes nerve signal transmission and preserves the integrity of the blood–brain barrier. Mg deficiency contributes to systemic low-grade inflammation, the common denominator of most diseases. In particular, neuroinflammation is the hallmark of neurodegenerative disorders. Starting from a rapid overview on the role of magnesium in the brain, this narrative review provides evidences linking the derangement of magnesium balance with multiple sclerosis, Alzheimer’s, and Parkinson’s diseases. |
| first_indexed | 2024-03-09T03:31:06Z |
| format | Article |
| id | doaj.art-04a7f3917d3847ab99eb67ef1aaacecb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:31:06Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-04a7f3917d3847ab99eb67ef1aaacecb2023-12-03T14:54:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124122310.3390/ijms24010223Magnesium and the Brain: A Focus on Neuroinflammation and NeurodegenerationJeanette A. M. Maier0Laura Locatelli1Giorgia Fedele2Alessandra Cazzaniga3André Mazur4Department of Biomedical and Clinical Sciences, Università di Milano, 20157 Milano, ItalyDepartment of Biomedical and Clinical Sciences, Università di Milano, 20157 Milano, ItalyDepartment of Biomedical and Clinical Sciences, Università di Milano, 20157 Milano, ItalyDepartment of Biomedical and Clinical Sciences, Università di Milano, 20157 Milano, ItalyUNH—Unité de Nutrition Humaine, Université Clermont Auvergne, INRAE, F-63000 Clermont-Ferrand, FranceMagnesium (Mg) is involved in the regulation of metabolism and in the maintenance of the homeostasis of all the tissues, including the brain, where it harmonizes nerve signal transmission and preserves the integrity of the blood–brain barrier. Mg deficiency contributes to systemic low-grade inflammation, the common denominator of most diseases. In particular, neuroinflammation is the hallmark of neurodegenerative disorders. Starting from a rapid overview on the role of magnesium in the brain, this narrative review provides evidences linking the derangement of magnesium balance with multiple sclerosis, Alzheimer’s, and Parkinson’s diseases.https://www.mdpi.com/1422-0067/24/1/223magnesiumbrainneuroinflammationblood–brain barrierneurodegeneration |
| spellingShingle | Jeanette A. M. Maier Laura Locatelli Giorgia Fedele Alessandra Cazzaniga André Mazur Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration International Journal of Molecular Sciences magnesium brain neuroinflammation blood–brain barrier neurodegeneration |
| title | Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration |
| title_full | Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration |
| title_fullStr | Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration |
| title_full_unstemmed | Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration |
| title_short | Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration |
| title_sort | magnesium and the brain a focus on neuroinflammation and neurodegeneration |
| topic | magnesium brain neuroinflammation blood–brain barrier neurodegeneration |
| url | https://www.mdpi.com/1422-0067/24/1/223 |
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