Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy
Spatially- and/or temporally-controlled drug release has always been the pursuit of drug delivery systems (DDSs) to achieve the ideal therapeutic effect. The abnormal pathophysiological characteristics of the tumor microenvironment, including acidosis, overexpression of special enzymes, hypoxia, and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.916952/full |
| _version_ | 1811238160807493632 |
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| author | Xiufeng Cong Jun Chen Ran Xu |
| author_facet | Xiufeng Cong Jun Chen Ran Xu |
| author_sort | Xiufeng Cong |
| collection | DOAJ |
| description | Spatially- and/or temporally-controlled drug release has always been the pursuit of drug delivery systems (DDSs) to achieve the ideal therapeutic effect. The abnormal pathophysiological characteristics of the tumor microenvironment, including acidosis, overexpression of special enzymes, hypoxia, and high levels of ROS, GSH, and ATP, offer the possibility for the design of stimulus-responsive DDSs for controlled drug release to realize more efficient drug delivery and anti-tumor activity. With the help of these stimulus signals, responsive DDSs can realize controlled drug release more precisely within the local tumor site and decrease the injected dose and systemic toxicity. This review first describes the major pathophysiological characteristics of the tumor microenvironment, and highlights the recent cutting-edge advances in DDSs responding to the tumor pathophysiological environment for cancer therapy. Finally, the challenges and future directions of bio-responsive DDSs are discussed. |
| first_indexed | 2024-04-12T12:36:56Z |
| format | Article |
| id | doaj.art-04ab8b1f085044799e6390e5f15e49c6 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T12:36:56Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-04ab8b1f085044799e6390e5f15e49c62022-12-22T03:32:52ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-06-011010.3389/fbioe.2022.916952916952Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor TherapyXiufeng Cong0Jun Chen1Ran Xu2Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Oncology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaSpatially- and/or temporally-controlled drug release has always been the pursuit of drug delivery systems (DDSs) to achieve the ideal therapeutic effect. The abnormal pathophysiological characteristics of the tumor microenvironment, including acidosis, overexpression of special enzymes, hypoxia, and high levels of ROS, GSH, and ATP, offer the possibility for the design of stimulus-responsive DDSs for controlled drug release to realize more efficient drug delivery and anti-tumor activity. With the help of these stimulus signals, responsive DDSs can realize controlled drug release more precisely within the local tumor site and decrease the injected dose and systemic toxicity. This review first describes the major pathophysiological characteristics of the tumor microenvironment, and highlights the recent cutting-edge advances in DDSs responding to the tumor pathophysiological environment for cancer therapy. Finally, the challenges and future directions of bio-responsive DDSs are discussed.https://www.frontiersin.org/articles/10.3389/fbioe.2022.916952/fulltumor microenvironmentbio-responsivenesscancer therapydrug delivery systempathophysiological characteristics |
| spellingShingle | Xiufeng Cong Jun Chen Ran Xu Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy Frontiers in Bioengineering and Biotechnology tumor microenvironment bio-responsiveness cancer therapy drug delivery system pathophysiological characteristics |
| title | Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy |
| title_full | Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy |
| title_fullStr | Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy |
| title_full_unstemmed | Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy |
| title_short | Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy |
| title_sort | recent progress in bio responsive drug delivery systems for tumor therapy |
| topic | tumor microenvironment bio-responsiveness cancer therapy drug delivery system pathophysiological characteristics |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.916952/full |
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